This book provides a well-illustrated, comprehensive, and up-to-date account of Hodgkin lymphoma. Epidemiology, pathogenesis, and the role of the microenvironment are examined in detail. The initial clinical evaluation and use of staging systems are fully discussed, and prognostic factors are carefully considered. The various treatment options for first-line and relapsed Hodgkin lymphoma are presented, including the newly available treatments for recurrent disease and the management required in special clinical circumstances. Given the very high cure rates and the young age of many patients, there is an increasing need to develop better individually tailored treatment strategies that will help to avoid both early and late side-effects of treatment. Such strategies receive due attention, and clear guidance is provided on the handling of Hodgkin survivors. This book will be of great value to hematologists, oncologists, and all others with an interest in Hodgkin lymphoma.
Author(s): Sally L. Glaser, Ellen T. Chang, Christina A. Clarke, Theresa H. Keegan (auth.), Andreas Engert, Sandra J. Horning (eds.)
Series: Hematologic Malignancies
Publisher: Springer Berlin Heidelberg
Year: 2011
Language: English
Pages: 371
Tags: Hematology; Oncology
Front Matter....Pages i-ix
Front Matter....Pages 1-1
Epidemiology....Pages 3-20
The Role of Viruses in the Genesis of Hodgkin Lymphoma....Pages 21-32
Pathology and Molecular Pathology of Hodgkin Lymphoma....Pages 33-48
Microenvironment, Cross-Talk, and Immune Escape Mechanisms....Pages 49-61
Front Matter....Pages 63-63
Clinical Evaluation....Pages 65-76
Functional Imaging....Pages 77-95
Prognostic Factors....Pages 97-115
Principles of Radiation Techniques in Hodgkin Lymphoma....Pages 117-139
Principles of Chemotherapy in Hodgkin Lymphoma....Pages 141-161
Treatment of Early Favorable Hodgkin Lymphoma....Pages 163-181
Treatment of Early Unfavorable HL....Pages 183-190
Treatment of Advanced Stage Hodgkin Lymphoma....Pages 191-202
Relapsed and Refractory Hodgkin Lymphoma....Pages 203-209
Pediatric Hodgkin Lymphoma....Pages 211-225
Front Matter....Pages 227-227
Lymphocyte-Predominant Hodgkin Lymphoma....Pages 229-239
The Management of Hodgkin Lymphoma During Pregnancy....Pages 241-248
The Management of HIV-Hodgkin Lymphoma....Pages 249-258
The Management of Elderly Patients with Hodgkin Lymphoma....Pages 259-272
Allogeneic Transplantation for Relapsed Hodgkin Lymphoma....Pages 273-281
New Agents for Patients with Hodgkin Lymphoma....Pages 283-294
Front Matter....Pages 295-295
Quality of Life in Hodgkin Lymphoma....Pages 297-303
Second Malignancy Risk After Treatment of Hodgkin Lymphoma....Pages 305-331
Cardiovascular and Pulmonary Late Effects....Pages 333-344
Gonadal Dysfunction and Fertility Preservation in Hodgkin Lymphoma Patients....Pages 345-354
Front Matter....Pages 355-355
What Will We Learn from Genomics and Proteomics in Hodgkin Lymphoma?....Pages 357-365
Personalized Medicine in Hodgkin Lymphoma?....Pages 367-372
Back Matter....Pages 373-381
