Within the last decade there have been a number of new and important areas of emphasis in HIV care and research, particularly in the context of brain involvement. Without question, clinical and research innovations in the modern era of the HIV pandemic warrant an update on HIV and the brain. Written by a panel of leading experts, HIV and the Brain: New Challenges in the Modern Era offers a clear picture of brain impairment associated with the virus with particular focus on three emerging areas including different genetic strains of the virus throughout the world, interactions between advanced age and HIV, and the impact of HIV on the brain in the context of chronic, long-term treatment with highly active antiretroviral therapy (HAART). HIV and the Brain: New Challenges in the Modern Era provides a comprehensive review of both basic science and clinical implications in these important areas of the disease. The text is of particular relevance to both research scientists and clinicians involved in HIV in the modern era.
Author(s): Erna Milunka Kojic, Charles C.J. Carpenter (auth.), Robert H. Paul PhD, Ned Charlton Sacktor, Victor Valcour, Karen Tokie Tashima (eds.)
Series: Current Clinical Neurology
Edition: 1
Publisher: Humana Press
Year: 2009
Language: English
Pages: 350
Tags: Neurology; Infectious Diseases; Internal Medicine; Immunology; Pain Medicine
Front Matter....Pages i-xiv
Neurocognitive Changes in AIDS: Evolution of Treatment of HIV Infection....Pages 1-8
Global Incidence and Epidemiology of the AIDS Pandemic, Distribution of HIV Subtypes, and Epidemiology of Hepatitis C Infection Among HIV-Positive Individuals....Pages 9-16
New Insights into HIV Neuropathogenesis....Pages 17-27
Neuropathological Findings Associated with Long-Term HAART....Pages 29-47
Biomarkers of HIV-Related Central Nervous System Disease....Pages 49-73
Neuroimaging Among HIV-Infected Patients: Current Knowledge and Future Directions....Pages 75-107
The Assessment of HIV-Associated Neurocognitive Disorders: New Challenges in the HAART Era....Pages 109-132
The Changing Face of HIV-Associated Cognitive and Neuropsychiatric Disturbance....Pages 133-186
Youth with HIV/AIDS: Neurobehavioral Consequences....Pages 187-211
Co-Occurrence of HIV, Hepatitis C, and Substance Use Disorders: Effects on Brain Functioning....Pages 213-232
The Functional Impact of HIV-Associated Neuropsychological Decline....Pages 233-248
Adjunctive Therapy for Long-Term Support of Cognitive Impairment....Pages 249-266
HIV-1 Genetic Diversity and Its Biological Significance....Pages 267-291
Opportunistic Infections in the Brain in Developing Countries....Pages 293-317
Impact of Clade Diversity on Neuropsychological Outcomes....Pages 319-329
The Effects of Aging on HIV Disease....Pages 331-346
Neuropsychology of Healthy Aging....Pages 347-367
Interactions Between Advanced Age and HIV Cognitive Impairment....Pages 369-391
Back Matter....Pages 393-400
