Liver disease has been identified as a leading cause of death in HIV-infected patients since the introduction of highly active antiretroviral therapy (HAART) in 1996. The HIV treatment community has been caught largely unaware of this emerging dilemma. Many HIV care providers are ill-equipped to understand and interpret liver injury patterns, or to provide comprehensive care and management for viral coinfections which they are not familiar with.
HIV and Liver Disease provides a comprehensive update of the field covering the epidemiology, pathogenesis, management and treatment of liver disease in patients with HIV infection. The volume will help HIV care providers understand and interpret liver injury patterns, and/or provide comprehensive care and management for viral coinfections. Gastroenterologists and hepatologists will gain an understanding of complex drug regimens that are used to treat HIV and which may impact HCV and HBV treatment. Written by expert clinicians and researchers across multiple disciplines, HIV and Liver Disease will be of great value to gastroenterologists, hepatologists, infectious disease practitioners, as well as other health care providers who provide care or participate in research in the field of HIV.
Author(s): John T. Brooks MD, Mi Chen MS (auth.), Kenneth E. Sherman (eds.)
Edition: 1
Publisher: Springer-Verlag New York
Year: 2012
Language: English
Pages: 209
Tags: Gastroenterology; Hepatology; Internal Medicine
Front Matter....Pages i-xiii
The HIV Epidemic in the USA: Current Trends, 2010....Pages 1-7
Epidemiology of Liver Disease in Human Immunodeficiency Virus-Infected Persons....Pages 9-13
Current and Future Treatment Guidelines for HIV....Pages 15-21
Pathology of HIV-Associated Liver Disease....Pages 23-31
Noninvasive Markers of Liver Injury and Fibrosis....Pages 33-44
Mechanisms of Alcoholic Steatosis/Steatohepatitis....Pages 45-54
Immunopathogenesis of Liver Injury....Pages 55-65
Host Gene Polymorphisms and Disease/Treatment Outcomes in HIV and Viral Coinfections....Pages 67-80
Effects of HIV on Liver Cell Populations....Pages 81-90
HIV Replication....Pages 91-99
Hepatitis C: Natural History....Pages 101-105
Natural History of Hepatitis B Virus in HIV-Infected Patients....Pages 107-111
Other Hepatitis Viruses and HIV Infection....Pages 113-123
Hepatitis B Virus: Replication, Mutation, and Evolution....Pages 125-132
Hepatitis C Virus Treatment in HIV....Pages 133-139
Treatment of Hepatitis B in HIV-Infected Persons....Pages 141-149
Prevention of Hepatitis Infection in HIV-Infected Patients....Pages 151-161
Antiretroviral Therapy and Hepatotoxicity....Pages 163-170
Management of End-Stage Liver Disease and the Role of Liver Transplantation in HIV-Infected Patients....Pages 171-179
Assessment and Treatment of Alcohol- and Substance-Use Disorders in Patients with HIV Infection....Pages 181-188
Racial Disparities in HIV and Liver Disease....Pages 189-194
Quality of Life in Patients with HIV Infection and Liver Disease....Pages 195-204
Back Matter....Pages 205-209
