Early detection of colorectal cancers is a significant and relatively recent achievement. Persons who carry genetic mutations linked to hereditary colorectal cancer make up 20% of the patient population. With the advent of molecular genetics and the description of hereditary colorectal cancer syndromes, clinicians and genetic counselors are able to use genetic predisposition testing as an effective and important way to identify patients and families affected by inherited colorectal cancer syndromes. Hereditary Colorectal Cancer is a comprehensive collection that documents not only Familial Adenomatous Polyposis and the Lynch syndrome, but also less understood syndromes, including the Hamartomatous Polyposis Syndromes and MutYH Associated Polyposis. Internationally recognized clinicians and researchers further delve into the evolution and potential of syndromes, genes and molecular alterations that have yet to be defined. Instrumental experts in this field of discovery were carefully selected by the section editors to create this premier reference work for clinicians, scientists and researchers confronted with the treatment and management of hereditary colorectal cancer.
Author(s): Susan K. Clark, Kay F. Neale, Robin K. S. Phillips (auth.), Miguel A. Rodriguez-Bigas, Raul Cutait, Patrick M. Lynch, Ian Tomlinson, Hans F.A. Vasen (eds.)
Series: M.D. Anderson Solid Tumor Oncology Series 5
Edition: 1
Publisher: Springer US
Year: 2010
Language: English
Pages: 630
Tags: Oncology; Surgical Oncology; Gastroenterology
Front Matter....Pages i-xvii
Front Matter....Pages 1-1
History: Familial Adenomatous Polyposis....Pages 3-14
Historical Aspects of Lynch Syndrome....Pages 15-42
Front Matter....Pages 43-43
Molecular Genetics of Familial Adenomatous Polyposis....Pages 45-66
DNA Mismatch Repair....Pages 67-85
Basic Sciences and Genetics: Hamartomatous Polyposis....Pages 87-109
Hyperplastic Polyposis Syndrome: Colorectal Cancer Predisposition....Pages 111-131
MUTYH-Associated Polyposis....Pages 133-146
Polymorphic Variation and Risk of Colorectal Cancer....Pages 147-171
Front Matter....Pages 173-173
The Pathologist and the Phenotype of Hereditary Colorectal Cancer....Pages 175-194
Front Matter....Pages 195-195
Genotype Phenotype Correlation in Familial Adenomatous Polyposis....Pages 197-202
Surgery for Familial Adenomatous Polyposis....Pages 203-217
Duodenal Adenomas in Familial Adenomatous Polyposis....Pages 219-237
FAP-Associated Desmoid Tumours....Pages 239-251
Attenuated Familial Adenomatous Polyposis: Diagnosis, Management, and Future Prognosis....Pages 253-267
Front Matter....Pages 269-269
An Overview of the Lynch Syndrome (Hereditary Non-polyposis Colorectal Cancer)....Pages 271-299
Surgical Management in Lynch Syndrome....Pages 301-309
Extracolonic Tumors....Pages 311-333
Surveillance....Pages 335-346
Front Matter....Pages 347-347
MUTYH-Associated Polyposis....Pages 349-362
Front Matter....Pages 363-363
Peutz–Jeghers Syndrome....Pages 365-374
Front Matter....Pages 363-363
Clinical Aspects of Juvenile Polyposis....Pages 375-399
Hereditary Mixed Polyposis Syndrome and Multiple Adenoma Patients....Pages 401-408
Front Matter....Pages 409-409
Hyperplastic Polyposis....Pages 411-421
Front Matter....Pages 423-423
Genetic Counseling Overview....Pages 425-429
Across Culture and Health Systems: Europe....Pages 431-443
Across Culture and Health Systems: Asia (Hong Kong)....Pages 445-459
Across Culture and Health Systems: Asia (Japan)....Pages 461-469
Across Culture and Health Systems: Africa....Pages 471-486
Across Culture and Health Systems: Argentina....Pages 487-501
Genetic Counselling Across Culture and Health Systems: Australia....Pages 503-534
Across Culture and Health Systems: Korea....Pages 535-544
Across Culture and Health Systems: America....Pages 545-556
Front Matter....Pages 557-557
Psychological Impact of Genetic Counseling and Testing for Hereditary Colorectal Cancers....Pages 559-573
Front Matter....Pages 575-575
Chemoprevention for Inherited Colorectal Cancer....Pages 577-591
Front Matter....Pages 593-593
Registries....Pages 595-612
Erratumto: Chapter 22: Hereditary Mixed Polyposis Syndrome and Multiple Adenoma Patients....Pages E1-E1
Back Matter....Pages 613-627
