The international popularity of herbal remedies has recently outpaced quality information on the utilization and dosing of these compounds. This book fills a void in the literature by offering an authoritative overview of the mechanisms of herbal remedies and their impact on standard medications. It offers a practical approach that focuses not only on specific drug interactions, but the mechanisms behind those interactions and their clinical significance. With contributions from leading experts on the subject, this text examines the overall use of herbs, includes sections on individual herbs, and considers pertinent regulatory issues and concerns in industry.
Author(s): Francis Lam Y.W., Shiew-Mei Huang, Stephen D. Hall
Series: Drugs and the Pharmaceutical Sciences
Edition: 1
Publisher: Informa Healthcare
Year: 2006
Language: English
Pages: 360
Preface......Page 14
Contents......Page 16
Contributors......Page 22
1. The Landscape of Botanical Medicine Utilization and Safety......Page 26
2. Drug Interactions with Botanical Products......Page 50
3. In Vitro Inhibition with Botanical Products......Page 74
4. Drug Interactions with St. John’s Wort and Echinacea......Page 94
5. Botanical Products–Drug Interactions: Focus on Garlic, Ginkgo and Ginseng......Page 132
6. A Review of Chinese Botanical Product–Drug Interactions......Page 148
7. Drug Interactions of Grapefruit and Other Citrus—What Have We Learned?......Page 172
8. Quality Assurance and Standardization in Botanical Product–Drug Interaction: Evaluation and Documentation......Page 216
9. Pharmacokinetics of Botanical Products......Page 230
10. Drug–Drug, Drug–Dietary Supplement, Drug–Citrus Fruit, and Other Food Interactions—Labeling Implications......Page 270
11. FDA Perspectives on the Use of Postmarketing Reporting Systems to Evaluate Drug Interactions with CAHP*......Page 300
12. St. John’s Wort Drug Interaction Reports from FDA’s Postmarketing AERS......Page 310
13. Grapefruit Juice Interaction Reports from FDA’s Postmarketing AERS......Page 318
14. Botanicals as Drugs: A U.S. Perspective......Page 328
15. Development of Botanical Products as Pharmaceutical Agents......Page 344
Index......Page 352
