Hematologia Clinica

Wintrobe's Clinical Hematology CONTENTS......Page 2
Dedication......Page 12
Preface......Page 14
1 - Examination of the Blood and Bone Marrow......Page 16
2 - Clusters of Differentiation......Page 36
3 - Clinical Flow Cytometry......Page 95
4 - Cytogenetics......Page 114
5 - Molecular Biology and Hematology......Page 131
6 - Origin and Development of Blood Cells......Page 139
7 - Erythropoiesis......Page 160
8 - The Mature Erythrocyte......Page 177
9 - Destruction of Erythrocytes......Page 204
10 - Neutrophilic Leukocytes......Page 220
11 - The Human Eosinophil......Page 257
12 - Basophilic Leukocytes: Mast Cells and Basophils......Page 276
13 - Mononuclear Phagocytes......Page 288
14 - Phagocytosis......Page 322
15 - Lymphocytes and Lymphatic Organs......Page 339
16 - B Lymphocytes......Page 359
17 - T Lymphocytes and Natural Killer Cells......Page 387
18 - Effector Mechanisms in Immunity......Page 428
19 - Megakaryocytes and Platelets......Page 486
20 - Platelet Function in Hemostasis and Thrombosis......Page 527
21 - Blood Coagulation and Fibrinolysis......Page 547
22 - Endothelium: Angiogenesis and the Regulation of Hemostasis......Page 632
23 - Red Cell, Platelet, and White Cell Antigens......Page 643
24 - Transfusion Medicine......Page 674
25 - Hematopoietic Stem Cell Transplantation......Page 716
26 - Gene Therapy for Hematologic Disorders, Human Immunodeficiency Virus Infection, and Cancer......Page 740
27 - Anemia: General Considerations......Page 770
28 - Iron Deficiency and Related Disorders......Page 794
29 - Sideroblastic Anemias......Page 820
30 - Hemochromatosis......Page 840
31 - Porphyria......Page 861
32 - Hereditary Spherocytosis and Other Anemias Due to Abnormalities of the Red Cell Membrane......Page 887
33 - Hereditary Hemolytic Anemias Due to Enzyme Disorders......Page 908
34 - Mechanisms of Immune Destruction of Erythrocytes......Page 929
35 - Autoimmune Hemolytic Anemias......Page 941
36 - Alloimmune Hemolytic Disease of the Fetus and Newborn......Page 963
37 - Paroxysmal Nocturnal Hemoglobinuria......Page 980
38 - Acquired Nonimmune Hemolytic Disorders......Page 996
39 - Abnormal Hemoglobins: General Principles......Page 1018
40 - Sickle Cell Anemia and Other Sickling Syndromes......Page 1032
41 - Unstable Hemoglobin Disease......Page 1073
42 - Thalassemias and Related Disorders: Quantitative Disorders of Hemoglobin Synthesis......Page 1078
43 - Megaloblastic Anemias: Disorders of Impaired DNA Synthesis......Page 1118
44 - Acquired and Inherited Aplastic Anemia Syndromes......Page 1142
45 - Red Cell Aplasia......Page 1161
46 - Congenital Dyserythropoietic Anemias......Page 1177
47 - Anemias Secondary to Chronic Disease and Systemic Disorders......Page 1182
48 - Anemias Unique to Pregnancy and the Perinatal Period......Page 1201
49 - Hemoglobins Associated with Cyanosis: Methemoglobinemia and Low-Affinity Hemoglobins......Page 1219
50 - Erythrocytosis......Page 1225
51 - Diagnostic Approach to the Bleeding Disorders......Page 1238
52 - Thrombocytopenia: Pathophysiology and Classification......Page 1253
53 - Thrombocytopenia Caused by Immunologic Platelet Destruction......Page 1256
54 - Thrombotic Thrombocytopenic Purpura and Other Forms of Nonimmunologic Platelet Destruction......Page 1276
55 - Miscellaneous Causes of Thrombocytopenia......Page 1286
56 - Bleeding Disorders Caused by Vascular Abnormalities......Page 1293
57 - Thrombocytosis......Page 1307
58 - Qualitative Disorders of Platelet Function......Page 1318
59 - Inherited Coagulation Disorders......Page 1333
60 - Acquired Coagulation Disorders......Page 1374
61 - Thrombosis and Antithrombotic Therapy......Page 1411
62 - Diagnostic Approach to Malignant and Nonmalignant Disorders of the Phagocytic and Immune Systems......Page 1448
63 - Neutropenia......Page 1460
64 - Qualitative Disorders of Leukocytes......Page 1482
65 - Abnormalities of the Monocyte-Macrophage System: Lysosomal Storage Diseases......Page 1497
66 - Langerhans Cell Histiocytosis......Page 1502
67 - Infectious Mononucleosis and Other Epstein-Barr Virus–Related Disorders......Page 1511
68 - Primary Immunodeficiency Syndromes......Page 1534
69 - Acquired Immunodeficiency Syndrome......Page 1542
70 - Disorders of the Spleen......Page 1555
71 - Hematopoietic-Lymphoid Neoplasms: Principles of Diagnosis......Page 1567
72 - Complications of Hematopoietic Neoplasms......Page 1572
73 - Principles and Pharmacology of Chemotherapy......Page 1593
74 - Immunotherapy......Page 1612
75 - Supportive Care in Hematologic Malignancies......Page 1633
76 - Molecular Genetics of Acute Leuke......Page 1673
77 - Classification and Differentiation of the Acute Leukemias......Page 1687
78 - Acute Lymphoblastic Leukemia in Adults......Page 1697
79 - Acute Myeloid Leukemia in Adults......Page 1713
80 - Acute Lymphoblastic Leukemia in Children......Page 1752
81 - Acute Myelogenous Leukemia in Children......Page 1775
82 - Acute Promyelocytic Leukemia......Page 1785
83 - Myelodysplastic Syndromes......Page 1793
84 - Chronic Myeloid Leukemia......Page 1809
85 - Polycythemia Vera......Page 1822
86 - Myelofibrosis......Page 1835
87 - Systemic Mastocytosis......Page 1847
88 - Diagnosis and Classification of Non-Hodgkin Lymphomas......Page 1861
89 - Molecular Aspects of Non-Hodgkin Lymphomagenesis......Page 1879
90 - Non-Hodgkin Lymphomas in Adults......Page 1912
91 - Non-Hodgkin Lymphomas in Children......Page 1955
92 - Chronic Lymphocytic Leukemia......Page 1971
93 - Hairy Cell Leukemia......Page 2000
94 - Cutaneous T-Cell Lymphomas: Mycosis Fungoides and Sézary Syndrome......Page 2018
95 - Hodgkin Disease......Page 2050
96 - Practical Aspects of the Clinical Approach to Patients with Monoclonal Immunoglobulin Disorders......Page 2081
97 - Monoclonal Gammopathy of Undetermined Significance and Smoldering Multiple Myeloma......Page 2090
98 - Multiple Myeloma......Page 2107
99 - Immunoglobulin Light-Chain Amyloidosis (Primary Amyloidosis)......Page 2154
100 - Waldenström Macroglobulinemia......Page 2180
101 - Cryoglobulinemia, Heavy Chain Diseases, and Monoclonal Gammopathy–Associated Disorders......Page 2194
Color Plate......Page 2227