Gain a full understanding of the principles of biochemistry as it relates to clinical medicine
The Thirty-First Edition of Harper’s Illustrated Biochemistry continues to emphasize the link between biochemistry and the understanding of disease states, disease pathology, and the practice of medicine. Featuring a full-color presentation and numerous medically relevant examples, Harper’s presents a clear, succinct review of the fundamentals of biochemistry that every student must understand in order to succeed in medical school.
All 58 chapters help you understand the medical relevance of biochemistry:
•Full-color presentation includes more than 600 illustrations
•Case studies emphasize the clinical relevance of biochemistry
•NEW CHAPTER on Biochemistry of Transition Metals addresses the importance and overall pervasiveness of transition metals
•Review Questions follow each of the eleven sections
•Boxed Objectives define the goals of each chapter
•Tables encapsulate important information
•Every chapter includes a section on the biomedical importance of a given topic
NEW TO THIS EDITION:
•Emphasis throughout on the integral relationship between biochemistry and disease, diagnostic pathology, and medical practice
•Hundreds of references to disease states throughout
•New chapter addressing the biochemical roles of transition metals
•Many updated review questions
•Frequent tables summarizing key links to disease states
•New text on cryo-electron microscopy (cryo-EM)
•Cover picture of the protein structure of the Zika virus, solved by cryo-EM
Applauded by medical students and online reviewers for its currency and engaging style, Harper’s Illustrated Biochemistry is essential for USMLE® review and the single-best reference for learning the clinical relevance of any biochemistry topic.
Author(s): Victor W. Rodwell, David A. Bender, Kathleen M. Botham, Peter J. Kennelly, P. Anthony Weil
Series: The God of Education
Edition: 31st
Publisher: McGraw-Hill Education
Year: 2018
Language: English
Pages: 800
City: Ankara
Cover......Page 1
Title Page......Page 2
Copyright Page......Page 3
Coauthors......Page 4
Contents......Page 6
Preface......Page 10
1 Biochemistry & Medicine......Page 12
2 Water & pH......Page 17
3 Amino Acids & Peptides......Page 25
4 Proteins: Determination of Primary Structure......Page 34
5 Proteins: Higher Orders of Structure......Page 44
6 Proteins: Myoglobin & Hemoglobin......Page 58
7 Enzymes: Mechanism of Action......Page 67
8 Enzymes: Kinetics......Page 79
9 Enzymes: Regulation of Activities......Page 93
10 The Biochemical Roles of Transition Metals......Page 103
11 Bioenergetics: The Role of ATP......Page 116
12 Biologic Oxidation......Page 122
13 The Respiratory Chain & Oxidative Phosphorylation......Page 128
14 Overview of Metabolism & the Provision of Metabolic Fuels......Page 140
15 Carbohydrates of Physiological Significance......Page 152
16 The Citric Acid Cycle: The Central Pathway of Carbohydrate, Lipid, & Amino Acid Metabolism......Page 161
17 Glycolysis & the Oxidation of Pyruvate......Page 168
18 Metabolism of Glycogen......Page 175
19 Gluconeogenesis & the Control of Blood Glucose......Page 183
20 The Pentose Phosphate Pathway & Other Pathways of Hexose Metabolism......Page 193
21 Lipids of Physiologic Significance......Page 206
22 Oxidation of Fatty Acids: Ketogenesis......Page 218
23 Biosynthesis of Fatty Acids & Eicosanoids......Page 227
24 Metabolism of Acylglycerols & Sphingolipids......Page 240
25 Lipid Transport & Storage......Page 247
26 Cholesterol Synthesis, Transport, & Excretion......Page 260
27 Biosynthesis of the Nutritionally Nonessential Amino Acids......Page 274
28 Catabolism of Proteins & of Amino Acid Nitrogen......Page 280
29 Catabolism of the Carbon Skeletons of Amino Acids......Page 291
30 Conversion of Amino Acids to Specialized Products......Page 307
31 Porphyrins & Bile Pigments......Page 316
32 Nucleotides......Page 330
33 Metabolism of Purine & Pyrimidine Nucleotides......Page 338
34 Nucleic Acid Structure & Function......Page 349
35 DNA Organization, Replication, & Repair......Page 361
36 RNA Synthesis, Processing, & Modification......Page 385
37 Protein Synthesis & the Genetic Code......Page 404
38 Regulation of Gene Expression......Page 420
39 Molecular Genetics, Recombinant DNA, & Genomic Technology......Page 443
40 Membranes: Structure & Function......Page 470
41 The Diversity of the Endocrine System......Page 491
42 Hormone Action & Signal Transduction......Page 511
43 Nutrition, Digestion, & Absorption......Page 530
44 Micronutrients: Vitamins & Minerals......Page 538
45 Free Radicals & Antioxidant Nutrients......Page 552
46 Glycoproteins......Page 557
47 Metabolism of Xenobiotics......Page 567
48 Clinical Biochemistry......Page 571
49 Intracellular Traffic & Sorting of Proteins......Page 584
50 The Extracellular Matrix......Page 603
51 Muscle & the Cytoskeleton......Page 622
52 Plasma Proteins & Immunoglobulins......Page 638
53 Red Blood Cells......Page 657
54 White Blood Cells......Page 667
55 Hemostasis & Thrombosis......Page 680
56 Cancer: An Overview......Page 692
57 The Biochemistry of Aging......Page 718
58 Biochemical Case Histories......Page 730
The Answer Bank......Page 742
A......Page 746
B......Page 751
C......Page 752
D......Page 758
E......Page 761
F......Page 763
G......Page 765
H......Page 769
I......Page 772
L......Page 774
M......Page 777
N......Page 780
O......Page 782
P......Page 783
R......Page 789
S......Page 792
T......Page 794
V......Page 798
W......Page 799
Z......Page 800
