The use of small animal models in basic and preclinical sciences constitutes an integral part of testing new pharmaceutical agents prior to their application in clinical practice. New imaging and therapeutic approaches need to be tested and validated first in animals before application to humans.
Handbook of Small Animal Imaging: Preclinical Imaging, Therapy, and Applications collects the latest information about various imaging and therapeutic technologies used in preclinical research into a single source. Useful to established researchers as well as newcomers to the field, this handbook shows readers how to exploit and integrate these imaging and treatment modalities and techniques into their own research.
The book first presents introductory material on small animal imaging, therapy, and research ethics. It next covers ionizing radiation and nonionizing radiation methods in small animal imaging, hybrid imaging, and imaging agents. The book then addresses therapeutic research platforms and image quantification, explaining how to ensure accurate measurements of high-quality data. It concludes with an overview of many small animal imaging and therapy applications that demonstrate the strength of the techniques in biomedical fields.
Author(s): George C. Kagadis, Nancy L. Ford, Dimitrios N. Karnabatidis, George K. Loudos
Series: Imagining in Medical Diagnosis and Therapy
Publisher: CRC Press
Year: 2016
Language: English
Pages: 623
City: Boca Raton
Cover
Half Title
Title Page
Copyright Page
Dedication
Table of Contents
Series Preface
Preface
Editors
Contributors
Section I—Introduction to Small Animal Imaging, Therapy, and Applications
Chapter 1. Defining Small Animal Imaging, Therapy, and Applications
Chapter 2. Ethics and Regulations for Research with Animals
Chapter 3. Small Animal Handling, Care, and Anesthesia
Chapter 4. Preclinical Models
Section II—Small Animal Imaging: Ionizing Radiation
Chapter 5. Microcomputed Tomography
Chapter 6. Digital Subtracted Angiography of Small Animals
Chapter 7. Single-Photon Emission Computed Tomography
Chapter 8. Positron Emission Tomography
Section III—Small Animal Imaging: Nonionizing Radiation
Chapter 9. MR Imaging
Chapter 10. Optical Imaging
Section IV—Hybrid Imaging
Chapter 11. Optical-CT Imaging
Chapter 12. PET/CT
Chapter 13. Introduction to Combining MRI with PET
Chapter 14. Exotic Imaging Approaches
Section V—Imaging Agents
Chapter 15. X-Ray, MRI, and Ultrasound Agents: Basic Principles
Chapter 16. Radiochemistry for Preclinical Imaging Studies
Chapter 17. Molecular Targets and Optical Probes
Section VI—Therapeutic Research Platforms
Chapter 18. Developing Technologies for Small Animal Radiotherapy
Chapter 19. Dosimetry of Ionizing Radiation in Small Animal Imaging
Chapter 20. Treatment Planning for Small Animals
Chapter 21. Radiolabeled Agents for Molecular Imaging and/or Therapy
Section VII—Image Quantification
Chapter 22. Quantification in Nuclear Preclinical Imaging
Chapter 23. Performance Assessment of Small Animal Imaging Systems and Common Standards
Chapter 24. Monte Carlo Simulations in Imaging and Therapy
Section VIII—Applications
Chapter 25. Small Animal Imaging and Therapy: How They Affect Patient Care
Chapter 26. Applications for Drug Development
Chapter 27. Imaging of Intracellular Targets
Chapter 28. Imaging of Cell Trafficking and Cell Tissue Homing
Chapter 29. Imaging of Cardiovascular Disease
Chapter 30. Imaging Angiogenesis
Chapter 31. Imaging of Hypoxia, Apoptosis, and Inflammation
Chapter 32. Vessel Wall Imaging
Index
