Polymers are one of the most fascinating materials of the present era finding their applications in almost every aspects of life. Polymers are either directly available in nature or are chemically synthesized and used depending upon the targeted applications.Advances in polymer science and the introduction of new polymers have resulted in the significant development of polymers with unique properties. Different kinds of polymers have been and will be one of the key in several applications in many of the advanced pharmaceutical research being carried out over the globe.
This 4-partset of books contains precisely referenced chapters, emphasizing different kinds of polymers with basic fundamentals and practicality for application in diverse pharmaceutical technologies. The volumes aim at explaining basics of polymers based materials from different resources and their chemistry along with practical applications which present a future direction in the pharmaceutical industry. Each volume offer deep insight into the subject being treated.
Volume 1: Structure and Chemistry
Volume 2: Processing and Applications
Volume 3: Biodegradable Polymers
Volume 4: Bioactive and Compatible Synthetic/Hybrid Polymers
Author(s): Thakur, Manju Kumari; Thakur, Vijay Kumar
Publisher: Wiley-Scrivener
Year: 2015
Language: English
Pages: 496
Tags: Химия и химическая промышленность;Высокомолекулярные соединения;
Content: Cover
Title Page
Copyright Page
Dedication
Contents
Preface
1 Gellan as Novel Pharmaceutical Excipient
1.1 Introduction
1.2 Structural Properties of Gellan
1.3 Physiochemical Properties of Gellan
1.3.1 Gelling Features and Texture Properties
1.3.2 Rheology
1.3.3 Biosafety and Toxicological Studies
1.4 Pharmaceutical Applications of Gellan
1.4.1 Gellan-Based Pharmaceutical Formulations
1.4.1.1 Gel Formulations
1.4.1.2 Mucoadhesive Formulations
1.4.1.3 Granulating/Adhesive Agents and Tablet Binders
1.4.1.4 Controlled Release Dosage Form
1.4.1.5 Microspheres and Microcapsules 1.4.1.6 Gellan Beads1.4.1.7 Gellan Films
1.4.1.8 Gellan Nanohydrogels
1.4.1.9 Gellan Nanoparticles
1.4.2 Role of Gellan Excipients in Drug Delivery and Wound Healing
1.4.2.1 Ophthalmic Drug Delivery
1.4.2.2 Nasal Drug Delivery
1.4.2.3 Oral Drug Delivery
1.4.2.4 Buccal Drug Delivery
1.4.2.5 Periodontal Drug Delivery
1.4.2.6 Gastrointestinal Drug Delivery
1.4.2.7 Vaginal Drug Delivery
1.4.2.8 Colon Drug Delivery
1.4.2.9 Wound Healing
1.5 Conclusion and Future Perspectives
References
2 Application of Polymer Combinations in Extended Release Hydrophilic Matrices 2.1 Extended Release Matrices2.1.1 Polymers Used in ER Matrices
2.1.2 Water-Soluble (Hydrophilic) Polymers
2.1.3 Water-Insoluble Polymers
2.1.4 Fatty Acids/Alcohols/Waxes
2.2 Polymer Combinations Used in ER matrices
2.2.1 Compatibility and Miscibility of Polymers
2.2.2 Combination of Non-Ionic Polymers
2.3 Combination of Non-Ionic with Ionic Polymers
2.4 Combinations of Ionic Polymers
2.5 Other Polymer Combinations
2.6 Effect of Dissolution Method (Media) on Drug Release from ER Matrices Containing Polymer Combinations 2.7 Main Mechanisms of Drug-Polymer and/or Polymer-Polymer Interaction in ER Formulations2.8 Summary and Conclusions
References
3 Reagents for the Covalent Attachment of mPEG to Peptides and Proteins
3.1 Introduction
3.2 General Considerations about PEG Reagents and PEGylation Reactions
3.3 PEGylation of Amino Groups
3.3.1 PEGylation by Urethane Linkage Formation
3.3.2 PEGylation by Amide Linkage Formation
3.3.3 PEGylation by Reductive Amination
3.3.4 PEGylation by Alkylation
3.4 PEGylation of Thiol Groups
3.5 Reversible PEGylation
3.6 Enzymatic PEGylation 3.7 PEGylation of Carbohydrates Residues3.8 PEGylation by Click Chemistry
3.9 Other PEGylations
3.9.1 PEGylation at Arginine
3.9.2 PEGylation at Tirosine
3.9.3 PEGylation at Histidine
3.9.4 PEGylation at Carboxylic Groups
3.9.5 PEGylation with mPEG Isothiocyanate
3.10 Actual Trends
3.11 Conclusions
Acknowledgements
References
4 Critical Points and Phase Transitions in Polymeric Matrices for Controlled Drug Release
4.1 Introduction
4.2 Matrix Systems
4.2.1 Inert Matrices
4.2.2 Hydrophilic Matrices
4.2.3 Lipidic Matrices
