Volume 122, Elsеviеr, 2014 - 703 pages, ISBN: 0444520015 044463309X 9780444633095 9780444520012
This collection of review chapters provides a comprehensive reference into the science and clinical applications of the latest Multiple Sclerosis research and will be a valuable resource for the neuroscience research community and the clinical neurology community of researchers and practitioners.Multiple Sclerosis (MS) is generally understood to be an inflammatory autoimmune disease of the central nervous system. While we still are not certain of the root cause of MS, research results suggest that unknown environmental factors and the presence of specific genes seem the most probable targets. MS causes an inflammatory response in the central nervous system leading to neurodegeneration, oligodendrocyte death, axonal damage, and gliosis.
Over the past five years ongoing research has greatly expanded our understanding of the pathogenesis of MS, detailed insight into the epidemiology and genetic factors related to MS, the introduction of new technologies and tests to better diagnose and predict the future course of the disease and the introduction of new treatments targeting MS.
A comprehensive tutorial reference detailing our current foundational understanding of Multiple Sclerosis
Includes chapters on key topics including the genetics of MS, MRI imaging and MS, and the latest treatment options
Each chapter is translational and focuses on current research and impact on diagnosis and treatment options.Contents
Foreword
Preface
Contributors
SECTION 1 Pathogenesis
Immune regulation of multiple sclerosis
Pathology of multiple sclerosis and related inflammatory demyelinating diseases
The good and the bad of neuroinflammation in multiple sclerosis
Demyclination in multiple sclerosis
Axonal loss in multiple sclerosis: causes and mechanisms
Insights from magnetic resonance imaging
Infections and multiple sclerosis
The experimental autoimmune encephalomyelitis (EAE) model of MS: utility for understanding disease pathophysiology and treatment
SECTION 2 Epidemiology and genetics
Multiple sclerosis genetics
Genetics of primary progressive multiple sclerosis
The epidemiology of multiple sclerosit: insights to disease pathogenesis
SECTION 3 Diagnosis and disease course
Multiple sclerosis: diagnosis, differential diagnosis, and clinical presentation
MRI mimies of multiple sclerosis
Diagnosis of multiple sclerosis
The clinical course of multiple sclerosis
Early prognosis of multiple sclerosis
Clinical outcome measures in multiple sclerosis
MKI outcomes in the diagnosis and disease course of multiple sclerosis
Multiple sclerosis in children
SECTION 4 Treatment
Clinical trials in multiple sclerosis
Glucocorticoid treatment of multiple sclerosis
Disease-modifying agents in multiple sclerosis
Immunosuppressive treatments in multiple sclerosis
Symptomatic treatment and management of multiple sclerosis
Future treatment approaches to multiple sclerosis
SECTION 5 Other demyelinating diseases
Neuromyelitis optica (Devic's syndrome)
Acute disseminated encephalomyelitis and other inflammatory demyelinating variants
Acute inflammatory myelopathies
SECTION 6 Capita selecta
Clinical neurophysiology of multiple sclerosis
Cerebrospinal fluid analysis
Index
