Authoritative, Up-to-Date Coverage of Every Aspect of Poison Management A Doody's Core Title ESSENTIAL PURCHASE! 4 STAR DOODY'S REVIEW! "...the definitive reference for the field of toxicology. This update comes four years after the seventh edition and it retains much that has made this an authoritative textbook, adds 30 new chapters, and a "new to this edition" online link to color photographs....the breadth of Goldfrank's new edition makes it worth purchasing for anyone who frequently, or even occasionally, treats toxicologic cases, even for those who own earlier editions. The editors and authors are to be commended for their compulsive revision, with attention to detail, every four years of this authoritative book."--Doody's Review Service The #1 reference in the field for the last quarter of a century, Goldfrank's Toxicologic Emergencies, Eighth Edition, has been completely updated to equip emergency physicians with today's most authoritative guide to clinical toxicology. The book presents unsurpassed coverage of all aspects of toxicologic emergencies--from pharmacology and clinical presentation to treatment guidelines and case studies. Using a unique case-study approach, it fully examines general principles and techniques, the biochemical and molecular basis of toxicology, and how toxins affect vital signs, organs, and systems throughout the body. The completely updated Eighth Edition features: A case-based approach that maximizes understanding of clinical applications of the material Easy-to-find, detailed guidance on the use of antidotes Quick-reference tables on inside covers, providing immediate access to “must-have” vital-sign statistics, lab values, and common equations Expanded coverage of bioterrorism, inhalant abuse, and international considerations A companion website with more than 1200 self-assessment questions and annotated answers, critical cases in medical toxicology, and more than 100 color photos of plants, mushrooms, spiders, snakes, marine life, and dermatologic reactions of toxicologic importance The following material is available at goldfrankstoxicology.com: Study Guide Study Questions wiht Answers Case Studies with Answers Image Library (20060601)
Author(s): Neal E. Flomenbaum, Lewis R. Goldfrank, Robert S. Hoffman, Mary Ann Howland, Neal A. Lewin, Lewis S.
Edition: 8th
Year: 2006
Language: English
Pages: 2014
II - Poison Centers and Epidemiology......Page 0
Cover......Page 1
Editors and Authors......Page 2
Notice......Page 37
Dedicated to......Page 38
Acknowledgments......Page 40
Preface......Page 43
Table of Antidotes in Depth......Page 48
1 - Historical Principles and Perspectives......Page 52
Antidotes in Depth - Antiquated Antidotes......Page 127
2 - Toxicologic Plagues and Disasters in History......Page 149
3 - Initial Evaluation of the Patient - Vital Signs and Toxic Syndromes......Page 199
4 - Principles of Managing the Poisoned or Overdosed Patient......Page 218
5 - Electrocardiographic Principles......Page 250
6 - Diagnostic Imaging......Page 293
7 - Laboratory Principles......Page 386
8 - Techniques Used to Prevent Gastrointestinal Absorption......Page 454
8.1 - Antidotes in Depth - Syrup of Ipecac......Page 512
8.2 - Antidotes in Depth - Activated Charcoal......Page 530
8.3 - Antidotes in Depth - Whole-Bowel Irrigation and Other Intestinal Evacuants......Page 561
9 - Pharmacokinetic and Toxicokinetic Principles......Page 583
10 - Principles and Techniques Applied to Enhance Elimination......Page 654
11 - Use of the Intensive Care Unit......Page 696
12 - Chemical Principles......Page 732
13 - Biochemical and Metabolic Principles......Page 782
14 - Neurotransmitters and Neuromodulators......Page 839
15 - Withdrawal Principles......Page 982
16 - Thermoregulatory Principles......Page 1009
17 - Fluid, Electrolyte, and Acid-Base Principles......Page 1108
18 - Psychiatric Principles......Page 1188
19 - Neurologic Principles......Page 1233
20 - Ophthalmic Principles......Page 1318
21 - Otolaryngologic Principles......Page 1357
22 - Respiratory Principles......Page 1415
23 - Cardiovascular Principles......Page 1465
24 - Hematologic Principles......Page 1528
25 - Gastrointestinal Principles......Page 1608
26 - Hepatic Principles......Page 1663
27 - Renal Principles......Page 1712
28 - Genitourinary Principles......Page 1764
29 - Dermatologic Principles......Page 1828
30 - Reproductive and Perinatal Principles......Page 1863
31 - Pediatric Principles......Page 1947
32 - Geriatric Principles......Page 2006
33 - Postmortem Toxicology......Page 2038
Special Considerations - Organ Procurement from Poisoned Patients......Page 2077
34 - Acetaminophen......Page 2086
34.1 - Antidotes in Depth - N-Acetylcysteine......Page 2176
35 - Salicylates......Page 2201
35.1 - Antidotes in Depth - Sodium Bicarbonate......Page 2258
36 - Nonsteroidal Antiinflammatory Drugs......Page 2290
37 - Colchicine and Podophyllin......Page 2319
38 - Opioids......Page 2360
38.1 - Antidotes in Depth - Opioid Antagonists......Page 2459
39 - Dieting Agents and Regimens......Page 2486
40 - Iron......Page 2518
40.1 - Antidotes in Depth - Deferoxamine......Page 2552
41 - Vitamins......Page 2573
42 - Essential Oils......Page 2634
43 - Herbal Preparations......Page 2667
44 - Athletic Performance Enhancers......Page 2716
45 - Food Poisoning......Page 2769
46 - Botulism......Page 2824
46.1 - Antidotes in Depth - Botulinum Antitoxin......Page 2877
47 - Anticonvulsants......Page 2887
47.1 - Antidotes in Depth - L-Carnitine......Page 2939
48 - Antidiabetics and Hypoglycemics......Page 2952
48.1 - Antidotes in Depth - Dextrose......Page 3006
48.2 - Antidotes in Depth - Octreotide......Page 3033
49 - Thyroid and Antithyroid Medications......Page 3048
50 - Antihistamines and Decongestants......Page 3081
50.1 - Antidotes in Depth - Physostigmine Salicylate......Page 3119
51 - Antimigraine Medications......Page 3136
52 - Antineoplastics......Page 3161
52.1 - Antidotes in Depth - Leucovorin - Folinic Acid - and Folic Acid......Page 3252
53 - Pharmaceutical Additives......Page 3265
54 - Antibiotics, Antifungals, and Antivirals......Page 3319
55 - Antituberculous Medications......Page 3405
55.1 - Antidotes in Depth - Pyridoxine......Page 3448
56 - Antimalarials......Page 3463
57 - Anticoagulants......Page 3499
57.1 - Antidotes in Depth - Vitamin K1......Page 3567
57.2 - Antidotes in Depth - Protamine......Page 3582
58 - Calcium Channel Blockers......Page 3600
59 - beta-Adrenergic Antagonists......Page 3654
59.1 - Antidotes in Depth - Glucagon......Page 3704
60 - Other Antihypertensives......Page 3722
61 - Antidysrhythmics......Page 3780
62 - Cardioactive Steroids......Page 3820
62.1 - Antidotes in Depth - Digoxin-Specific Antibody Fragments - Fab......Page 3866
63 - Methylxanthines and Selective beta2-Adrenergic Agonists......Page 3893
64 - Local Anesthetics......Page 3956
65 - Inhalational Anesthetics......Page 4004
66 - Neuromuscular Blockers......Page 4032
66.1 - Antidotes in Depth - Dantrolene Sodium......Page 4078
67 - Antipsychotics......Page 4087
68 - Lithium......Page 4135
69 - Monoamine Oxidase Inhibitors......Page 4180
70 - Serotonin Reuptake Inhibitors and Atypical Antidepressants......Page 4213
71 - Cyclic Antidepressants......Page 4262
72 - Sedative-Hypnotics......Page 4324
72.1 - Antidotes in Depth - Flumazenil......Page 4388
73 - Amphetamines......Page 4414
74 - Cocaine......Page 4480
75 - Ethanol......Page 4544
75.1 - Antidotes in Depth - Thiamine Hydrochloride......Page 4607
76 - Ethanol Withdrawal......Page 4629
77 - Disulfiram and Disulfiramlike Reactions......Page 4662
78 - gamma-Hydroxybutyric Acid......Page 4698
79 - Inhalants......Page 4730
80 - Hallucinogens......Page 4768
81 - Cannabinoids......Page 4808
82 - Nicotine and Tobacco Preparations......Page 4847
83 - Phencyclidine and Ketamine......Page 4885
84 - Antimony......Page 4941
85 - Arsenic......Page 4962
85.1 - Antidotes in Depth - Dimercaprol - British Anti-Lewisite or BAL......Page 5023
86 - Bismuth......Page 5038
87 - Cadmium......Page 5057
88 - Chromium......Page 5085
89 - Cobalt......Page 5109
90 - Copper......Page 5152
91 - Lead......Page 5197
91.1 - Antidotes in Depth - Succimer - 2,3-Dimercaptosuccinic Acid......Page 5265
91.2 - Antidotes in Depth - Edetate Calcium Disodium - CaNa2EDTA......Page 5293
92 - Mercury......Page 5307
93 - Nickel......Page 5351
94 - Selenium......Page 5380
95 - Silver......Page 5404
96 - Thallium......Page 5422
96.1 - Antidotes in Depth - Prussian Blue......Page 5460
97 - Zinc......Page 5480
98 - Antiseptics, Disinfectants, and Sterilants......Page 5506
99 - Camphor and Moth Repellents......Page 5567
100 - Caustics......Page 5594
101 - Hydrofluoric Acid and Fluorides......Page 5643
101.1 - Antidotes in Depth - Calcium......Page 5673
102 - Hydrocarbons......Page 5693
103 - Toxic Alcohols......Page 5767
103.1 - Antidotes in Depth - Fomepizole......Page 5809
103.2 - Antidotes in Depth - Ethanol......Page 5833
104 - Pesticides - An Overview with a Focus on Principles and Rodenticides......Page 5850
105 - Barium......Page 5883
106 - Sodium Monofluoroacetate and Fluoroacetamide......Page 5896
107 - Phosphorus......Page 5908
108 - Strychnine......Page 5931
109 - Insecticides - Organic Phosphorus Compounds and Carbamates......Page 5955
109.1 - Antidotes in Depth - Pralidoxime......Page 6019
109.2 - Antidotes in Depth - Atropine......Page 6043
110 - Insecticides - Organic Chlorines, Pyrethrins-Pyrethroids, and DEET......Page 6058
111 - Herbicides......Page 6101
112 - Methyl Bromide and Other Fumigants......Page 6178
113 - Mushrooms......Page 6205
114 - Plants......Page 6255
115 - Arthropods......Page 6349
115.1 - Antidotes in Depth - Antivenom - Scorpion and Spider......Page 6432
116 - Marine Envenomations......Page 6453
117 - Snakes and Other Reptiles......Page 6515
117.1 - Antidotes in Depth - Antivenom - Crotaline and Elapid......Page 6562
118 - Industrial Poisoning - Information and Control......Page 6582
119 - Simple Asphyxiants and Pulmonary Irritants......Page 6627
120 - Carbon Monoxide......Page 6687
120.1 - Antidotes in Depth - Hyperbaric Oxygen......Page 6750
121 - Cyanide and Hydrogen Sulfide......Page 6784
121.1 - Antidotes in Depth - Sodium and Amyl Nitrites......Page 6841
121.2 - Antidotes in Depth - Sodium Thiosulfate......Page 6852
121.3 - Antidotes in Depth - Hydroxocobalamin......Page 6863
122 - Methemoglobin Inducers......Page 6872
122.1 - Antidotes in Depth - Methylene Blue......Page 6912
123 - Smoke Inhalation......Page 6925
124 - Risk Assessment and Risk Communication......Page 6964
125 - Hazmat Incident Response......Page 6988
126 - Chemical Weapons......Page 7034
127 - Biological Weapons......Page 7087
128 - Radiation......Page 7126
129 - Poison Prevention and Education......Page 7193
130 - Poison Information Centers and Poison Epidemiology......Page 7217
131 - International Perspectives in Medical Toxicology......Page 7247
132 - Principles of Epidemiology and Research Design......Page 7317
133 - Adverse Drug Events and Postmarketing Surveillance......Page 7354
134 - Medications, Errors, and Patient Safety......Page 7389
135 - Risk Management and Legal Principles......Page 7426
Appendices......Page 7452
