The elucidation during the latter half of the 20th century of the mechanisms by which information flows from nucleic acids to proteins has completely changed the face of biological research. Many diseases are caused by abnormalities in control mechanisms which are not immediately essential for life itself but which maintain the normal social behavior of differentiated cells in multicellular organisms. The complex sugar chains of glycoproteins and glycolipids are believed to play important roles in the control of cellular functions and in recognition between the cell and its cellular and fluid environment. Investigations into the abnormalities of complex sugar chain assembly are expected to yield an important new underatanding of the etiology and pathogenesis of human diseases. This volume discusses several representative diseases which emphasize the current status of glycopathology, and will stimulate further research in this exciting field.
Author(s): J. Montreuil, J.F.G. Vliegenthart and H. Schachter (Eds.)
Series: New comprehensive biochemistry 30
Publisher: Elsevier
Year: 1996
Language: English
Pages: ii-xxvi, 1-486
City: Amsterdam; New York
Content:
General Editors
Page ii
Editors
Page iii
Copyright page
Page iv
Preface
Page v
J. Montreuil, J.F.G. Vliegenthart, H. Schachter
List of contributors
Pages vii-ix
Previous volumes in the series
Pages xxiii-xxiv
Preliminary contents of volume 29b
Pages xxv-xxvi
Introduction to the volume
Page 1
Akira Kobata
Chapter 1a Normal and pathological catabolism of glycoproteins: The enzymes Original Research Article
Pages 3-54
George W. Jourdian
Chapter 1b Normal and pathological catabolism of glycoproteins: Catabolic pathways Original Research Article
Pages 55-97
Jean-Claude Michalski
Chapter 2a Glycoproteins of parasites: Glycoproteins of Trypanosoma cruzi Original Research Article
Pages 99-111
Bradley K. Hayes, Gerald W. Hart
Chapter 2b Glycoproteins of parasites: Glycoconjugates of Leishmania Original Research Article
Pages 113-124
Salvatore J. Turco
Chapter 2c Glycoproteins of parasites: Glycoproteins of malaria parasites Original Research Article
Pages 125-158
Angela Dieckmann-Schuppert, Peter Gerold, Ralph T. Schwarz
Chapter 2d Glycoproteins of parasites: Schistosoma glycoconjugates and their role in host-parasite pathological interactions Original Research Article
Pages 159-182
Govert J. van Dam, André M. Deelder
Chapter 3 Cancer cells and metastasis: Introduction
Page 183
Akira Kobata
Chapter 3a Cancer cells and metastasis: Choriocarcinoma and hCG Original Research Article
Pages 185-195
Ryuichiro Nishimura, Akira Kobata
Chapter 3b Cancer cells and metastasis: Hepatocellular carcinoma Original Research Article
Pages 197-210
Katsuko Yamashita, Akira Kobata
Chapter 3c Cancer cells and metastasis: The Warren-Glick phenomenon - a molecular basis of tumorigenesis and metastasis Original Research Article
Pages 211-227
Akira Kobata
Chapter 3d Cancer cells and metastasis: Carcinoembryonic antigen and related normal antigens Original Research Article
Pages 229-239
Katsuko Yamashita, Akira Kobata
Chapter 3 Cancer cells and metastasis: Concluding remarks
Page 241
Akira Kobata
Chapter 4 Tumor-associated carbohydrate antigens and modified blood group antigens Original Research Article
Pages 243-276
Sen-itiroh Hakomori
Chapter 5 Rheumatoid arthritis and serum IgG Original Research Article
Pages 277-289
Tamao Endo, Kiyoshi Furukawa
Chapter 6 Glycoproteins in inflammatory bowel disease Original Research Article
Pages 291-298
Milan Tomana
Chapter 7 HEMPAS: A genetic disorder caused by a defect in N-linked oligosaccharide synthesis Original Research Article
Pages 299-310
Michiko N. Fukuda
Chapter 8 Leukosialin and the Wiskott-Aldrich syndrome Original Research Article
Pages 311-329
Minoru Fukuda
Chapter 9 Progeroid form of Ehlers-Danlos syndrome Original Research Article
Pages 331-336
Hans Kresse
Chapter 10 Paroxysmal nocturnal hemoglobinuria Original Research Article
Pages 337-350
Motowo Tomita
Chapter 11 Human mucosal mucins in diseases Original Research Article
Pages 351-393
Philippe Roussel, Geneviè Lamblin
Chapter 12 Glycoproteins and lectins in multiple sclerosis and immune demyelinating human diseases Original Research Article
Pages 395-404
Jean-Pierre Zanetta
Chapter 13 Leukocyte adhesion deficiency Type II Original Research Article
Pages 405-411
James C. Paulson
Chapter 14 Polysialic acids of vertebrates: biosynthesis, structural diversity, tissue expression and functions Original Research Article
Pages 413-438
Jiirgen Roth
Chapter 15 Glycosylation defects in blood clotting Original Research Article
Pages 439-444
Michio Matsuda
Chapter 16a Carbohydrate-deficient glycoprotein syndrome: Type I Original Research Article
Pages 445-455
Katsuko Yamashita, Kousaku Ohno
Chapter 16b Carbohydrate-deficient glycoprotein syndrome: Type II: an autosomal recessive disease due to mutations in the N-acetylglucosaminyltransferase II gene Original Research Article
Pages 457-467
Jaak Jaeken, Genevieve Spik, Harry Schachter
Subject Index
Pages 469-486
