This book covers physiologic, metabolic and molecular imaging for gliomas. Gliomas are the most common primary brain tumors. Imaging is critical for glioma management because of its ability to noninvasively define the anatomic location and extent of disease. While conventional MRI is used to guide current treatments, multiple studies suggest molecular features of gliomas may be identified with noninvasive imaging, including physiologic MRI and amino acid positron emission tomography (PET). These advanced imaging techniques have the promise to help elucidate underlying tumor biology and provide important information that could be integrated into routine clinical practice.
The text outlines current clinical practice including common scenarios in which imaging interpretation impacts patient management. Gaps in knowledge and potential areas of advancement based on the application of more experimental imaging techniques will be discussed. In reviewing this book, readers will learn:
- current standard imaging methodologies used in clinical practice for patients undergoing treatment for glioma and the implications of emerging treatment modalities including immunotherapy
- the theoretical basis for advanced imaging techniques including diffusion and perfusion MRI, MR spectroscopy, CEST and amino acid PET
- the relationship between imaging and molecular/genomic glioma features incorporated in the WHO 2016 classification update and the potential application of machine learning
- about the recently adopted and FDA approved standard brain tumor protocol for multicenter drug trials
- of the gaps in knowledge that impede optimal patient management and the cutting edge imaging techniques that could address these deficits
Author(s): Whitney B. Pope (ed.)
Publisher: Springer
Year: 2020
Language: English
Pages: 286
Front Matter ....Pages i-xiv
Indications and Limitations of Conventional Imaging – Current Clinical Practice in the Context of Standard Therapy (Raymond Y. Huang, Patrick Y. Wen)....Pages 1-15
Surrogates for Disease Status: Contrast Enhancement Including Limitations of Pseudoprogression and Pseudoresponse (Elke Hattingen)....Pages 17-29
The Relationship Between Biological and Imaging Characteristics in Enhancing and Nonenhancing Glioma (Janine M. Lupo, Javier E. Villanueva-Meyer)....Pages 31-48
Contrast-Enhanced T1-Weighted Digital Subtraction for Increased Lesion Conspicuity and Quantifying Treatment Response in Malignant Gliomas (Benjamin M. Ellingson)....Pages 49-60
Advanced Physiologic Imaging: Perfusion – Theory and Applications (Philipp Kickingereder, Ji Eun Park, Jerrold L. Boxerman)....Pages 61-91
Advanced Physiologic Imaging: Diffusion – Theory and Applications (Peter S. LaViolette)....Pages 93-108
Parametric Response Map (PRM) Analysis Improves Response Assessment in Gliomas (Michael Cardenas, Craig J. Galban, Thomas L. Chenevert, Michelle Miller-Thomas, Brian D. Ross, Christina Tsien)....Pages 109-126
Review of WHO 2016 Changes to Classification of Gliomas; Incorporation of Molecular Markers (Derek R. Johnson, Caterina Giannini, Timothy J. Kaufmann)....Pages 127-138
Imaging Markers of Lower-Grade Diffuse Glioma (Melanie A. Morrison, Adam D. Waldman)....Pages 139-159
CEST, pH, and Glucose Imaging as Markers for Hypoxia and Malignant Transformation (Daniel Paech, Alexander Radbruch)....Pages 161-172
MRS for D-2HG Detection in IDH-Mutant Glioma (Ovidiu C. Andronesi, Tracy T. Batchelor, Daniel P. Cahill)....Pages 173-189
C-13 Hyperpolarized MR Spectroscopy for Metabolic Imaging of Brain Tumors (Pavithra Viswanath, Yan Li, Sabrina M. Ronen)....Pages 191-209
FET and FDOPA PET Imaging in Glioma (Norbert Galldiks, Philipp Lohmann, Francesco Cicone, Karl-Josef Langen)....Pages 211-221
Imaging Genomics (Cymon N. Kersch, Ramon F. Barajas Jr.)....Pages 223-239
Radiomics and Machine Learning (Julie Ferris, Peter D. Chang, Daniel S. Chow)....Pages 241-249
Immunotherapy and Gliomas (Elise Wang, Robert J. Young, Ankush Bhatia)....Pages 251-265
The Path Forward: The Standardized Brain Tumor Imaging Protocol (BTIP) for Multicenter Trials (Benjamin M. Ellingson, Marion Smits)....Pages 267-282
Back Matter ....Pages 283-286
