Apoptosis is an essential process in embryonic development and tissue homeostasis, particularly in the prevention of disease. Written from a genetic viewpoint, Genetics of Apoptosis first describes the molecular and cell biology of apoptosis, then examines the process in more detail in several model systems. This volume brings together contributions from internationally renowned authors, and will be a valuable reference to all researchers studying apoptosis.
Author(s): S. Grimm
Edition: 1
Publisher: Bios
Year: 2003
Language: English
Pages: 331
City: Oxford
Book Cover......Page 1
Title......Page 4
Contents......Page 5
Abbreviations......Page 10
Contributors......Page 13
Preface......Page 14
Introduction......Page 16
Death receptors in apoptosis......Page 20
The role of caspases in apoptosis......Page 50
Making sense of the Bcl-2 family of apoptosis regulators......Page 66
Functional domains in apoptosis proteins......Page 86
The role of the endoplasmic reticulum in apoptosis......Page 112
Mitochondria in apoptosis induction......Page 134
Regulators and applications of yeast apoptosis......Page 154
Evolution of cell death: caspase-mediated mechanisms in early metazoans; noncaspase mechanisms in single-celled eukaryotes......Page 164
Programmed cell death in C.elegans......Page 174
Apoptosis in Drosophila......Page 196
Cell-culture systems in apoptosis......Page 208
Caspase-independent cell death......Page 222
References......Page 244
Index......Page 322
