This book examines the principles underlying genetic predisposition to cancer in order to familiarise practising oncologists, geneticists and other professionals interested in cancer with this new and expanded field. The coverage is comprehensive, taking the reader from an introduction to genetic predisposition, through a discussion of the molecular biology and statistical techniques involved in the detection and cloning of predisposition genes to a consideration of familial cancer syndromes, encompassing rare and common cancers. The text also includes a discussion of genetic screening and cancer management options, and a consideration of the associated ethical and psychological issues. To reflect the rapid advances in the field since the first edition, the contents have been thoroughly updated with new chapters on the biological basis of cancer predisposition, population-based studies of susceptibility, Von-Hippel-Lindau syndrome and evaluation of management strategies for individuals at increased cancer risk.
Author(s): Rosalind A. Eeles, Douglas F. Easton, Bruce A. J. Ponder, Charis Eng
Series: Hodder Arnold Publication
Edition: 2
Publisher: A Hodder Arnold Publication
Year: 2004
Language: English
Pages: 467
Tags: Биологические дисциплины;Генетика;
Book title......Page 2
Contents......Page 6
Contributors......Page 8
Foreword......Page 12
Foreword......Page 14
Preface......Page 16
Acknowledgements......Page 18
E......Page 20
M......Page 21
Q......Page 22
W......Page 23
Colour plates
......Page 354
PART 1 BASIC PRINCIPLES......Page 24
1 Genetic predisposition to cancer: an introduction......Page 26
2 Biological basis of cancer predisposition......Page 34
3 From families to chromosomes: genetic linkage and association studies for finding cancer-predisposition genes......Page 44
4 From chromosomes to genes: how to isolate cancer-predisposition genes......Page 64
5 Screening for mutations in cancer-predisposition genes......Page 71
PART 2 INHERITED CANCER SYNDROMES......Page 84
6 Retinoblastoma: the paradigm for a genetically inherited cancer syndrome......Page 86
7 Neurofibromatosis types 1 and 2......Page 96
8a: Multiple endocrine neoplasia type 1......Page 120
8b: Multiple endocrine neoplasia type 2......Page 128
9 Wilms tumour and other childhood renal tumours......Page 142
10 Genetic susceptibility to renal cell carcinoma......Page 155
11 The Li–Fraumeni syndrome and the role of TP53 mutations in predisposition to cancer......Page 164
12 Cowden syndrome......Page 178
PART 3 CHROMOSOME FRAGILITY SYNDROMES AND THE GORLIN SYNDROME......Page 190
13 Clinical, cellular and mutational variations in ataxia telangiectasia......Page 192
14 Fanconi anaemia......Page 203
15 The Gorlin (nevoid basal cell carcinoma) syndrome......Page 216
16 Xeroderma pigmentosum, Cockayne syndrome and trichothiodystrophy: sun sensitivity, DNA repair defects and skin cancer......Page 237
PART 4 THE COMMON CANCERS......Page 256
17 Genetics and the common cancers......Page 258
18 Familial breast cancer......Page 271
19 The BRCA1 and BRCA2 genes......Page 279
20 Screening for breast cancer in high-risk populations......Page 300
21 Risk-reducing mastectomy......Page 309
22 The role of chemoprevention in breast cancer......Page 319
23 Familial ovarian cancer: genetics and management......Page 326
24 Familial colon cancer syndromes and their genetics......Page 338
25 Screening and management of familial colon cancer......Page 357
26 Familial prostate cancer and its management......Page 365
27 Familial melanoma and its management......Page 378
28 Familial predisposition to lung cancer......Page 386
29 Genetic susceptibility to carcinoma of the head and neck, stomach, and pancreas......Page 394
PART 5 PSYCHOSOCIAL, ETHICAL AND ORGANISATIONAL ISSUES......Page 415
30 The cancer family clinic......Page 417
31 Psychological issues in cancer genetics......Page 430
32 The ethics of testing for cancer-predisposition genes......Page 440
A......Page 451
B......Page 452
C......Page 453
D......Page 455
F......Page 456
G......Page 457
I......Page 458
L......Page 459
M......Page 460
N......Page 461
P......Page 462
R......Page 464
S......Page 465
T......Page 466
Z......Page 467
