Genetic Dissection of Complex Traits

Content:
Contributors to Volume 60
Pages XV-XIX

Preface to First Edition
Pages XXI-XXIII
D.C. Rao, M.A. Province

Preface to Second Edition
Pages XXV-XXVI
D.C. Rao, C. Charles Gu

Acknowledgments
Page XXVII

An Overview of the Genetic Dissection of Complex Traits Review Article
Pages 3-34
D.C. Rao

Familial Resemblance and Heritability Review Article
Pages 35-49
Treva K. Rice

Linkage and Association: Basic Concepts Review Article
Pages 51-74
Ingrid B. Borecki, Michael A. Province

Definition of Phenotype Review Article
Pages 75-105
Mary K. Wojczynski, Hemant K. Tiwari

Genotyping Platforms for Mass‐Throughput Genotyping with SNPs, Including Human Genome‐Wide Scans Review Article
Pages 107-139
Karen Maresso, Ulrich Broeckel

Genotyping Errors and Their Impact on Genetic Analysis Review Article
Pages 141-152
Michael B. Miller, Karen Schwander, D.C. Rao

Model‐Based Methods for Linkage Analysis Review Article
Pages 155-173
John P. Rice, Nancy L. Saccone, Jonathan Corbett

Contemporary Model‐Free Methods for Linkage Analysis Review Article
Pages 175-193
Laura Almasy, John Blangero

DNA Sequence‐Based Phenotypic Association Analysis Review Article
Pages 195-217
Nicholas J. Schork, Jennifer Wessel, Nathalie Malo

Family‐Based Methods for Linkage and Association Analysis Review Article
Pages 219-252
Nan M. Laird, Christoph Lange

Searching for Additional Disease Loci in a Genomic Region Review Article
Pages 253-292
Glenys Thomson, Lisa F. Barcellos, Ana M. Valdes

Methods for Handling Multiple Testing Review Article
Pages 293-308
Treva K. Rice, Nicholas J. Schork, D.C. Rao

Meta‐Analysis Methods Review Article
Pages 311-334
Thomas A. Trikalinos, Georgia Salanti, Elias Zintzaras, John P.A. Ioannidis

Haplotype‐Association Analysis Review Article
Pages 335-405
Nianjun Liu, Kui Zhang, Hongyu Zhao

Characterization of LD Structures and the Utility of HapMap in Genetic Association Studies Review Article
Pages 407-435
C. Charles Gu, Kai Yu, D.C. Rao

Associations Among Multiple Markers and Complex Disease: Models, Algorithms, and Applications Review Article
Pages 437-464
Themistocles L. Assimes, Adam B. Olshen, Balasubramanian Narasimhan, Richard A. Olshen

Study Designs for Genome‐Wide Association Studies Review Article
Pages 465-504
Peter Kraft, David G. Cox

Ethical, Legal, and Social Implications of Biobanks for Genetics Research Review Article
Pages 505-544
Susanne B. Haga, Laura M. Beskow

Admixture Mapping and the Role of Population Structure for Localizing Disease Genes Review Article
Pages 547-569
Xiaofeng Zhu, Hua Tang, Neil Risch

Integrating Global Gene Expression Analysis and Genetics Review Article
Pages 571-601
Charles R. Farber, Aldons J. Lusis

A Systems Biology Approach to Drug Discovery Review Article
Pages 603-635
Jun Zhu, Bin Zhang, Eric E. Schadt

The Promise of Composite Likelihood Methods for Addressing Computationally Intensive Challenges Review Article
Pages 637-654
Na Li

Comparative Genomics for Detecting Human Disease Genes Review Article
Pages 655-697
Carol Moreno, Jozef Lazar, Howard J. Jacob, Anne E. Kwitek

From Genetics to Mechanism of Disease Liability Review Article
Pages 701-726
Andreas Rohrwasser, Paul Lott, Robert B. Weiss, Jean‐Marc Lalouel

Into the Post‐HapMap Era Review Article
Pages 727-742
Newton E. Morton

Index
Pages 743-760