Arab populations have their “own” genetic disorders, both universal and particular. Genetic diversity within these source populations, along with the fact that the rates of inbreeding are often high and family sizes are often large, constitute conditions that facilitate the emergence and detection of phenotypes explained notably by autosomal recessive inheritance; in which case, the use of homozygosity gene mapping can facilitate the discovery of the corresponding genes. The present book includes 5 parts dealing with various aspects that relate to the genetic structure of Arabs and minorities within the Arab world as well as genetic disorders prevalent in this part of the world. It includes updated reviews of the genetic disorders in various Arab countries and geographic regions. The focus is primarily, but not exclusively, on the group of single-gene disorders with particular emphasis on autosomal recessive conditions. It further includes epidemiological and clinical data as well as inheritance patterns, mutation and polymorphism data, and available haplotype analysis data. The ethnic and genetic diversity of the Arab populations is discussed as well as aspects of genetic counseling practice in this region together with a proposal for an ethical framework for genetic research and prevention of genetic disorders. The target audience of this book includes human and medical geneticists, genetic counselors, researchers, medical specialists dealing with Arab patients or practicing in Arab countries, medical and genetic counseling students, and nurses.
Author(s): Ahmad S. Teebi (auth.), Ahmad S. Teebi (eds.)
Edition: 2
Publisher: Springer-Verlag Berlin Heidelberg
Year: 2010
Language: English
Pages: 772
Tags: Human Genetics
Front Matter....Pages i-xvii
Front Matter....Pages 1-1
Introduction: Genetic Diversity Among Arabs....Pages 3-34
Front Matter....Pages 35-35
Arab Demography and Health Provision....Pages 37-63
Influences of Systems’ Resources and Health Risk Factors on Genetic Services....Pages 65-83
Endogamy and Consanguineous Marriage in Arab Populations....Pages 85-108
Front Matter....Pages 109-109
Familial Mediterranean Fever and Other Autoinflammatory Disorders....Pages 111-143
Muscular Dystrophies and Myopathies in Arab Populations....Pages 145-179
New Syndromes First Reported Among Arabs....Pages 181-216
Front Matter....Pages 217-217
Genetic Disorders in Egypt....Pages 219-272
Genetic Disorders in Ancient Egypt....Pages 273-295
Genetic Diseases in Iraq....Pages 297-323
Genetic Disorders in Jordan....Pages 325-352
Genetic Disorders in Kuwait....Pages 353-375
Genetic Disorders in Lebanon....Pages 377-441
Genetic Disorders in Libya....Pages 443-454
Genetic Disorders in Morocco....Pages 455-472
Genetic Disorders in Oman....Pages 473-490
Genetic Disorders Among the Palestinians....Pages 491-514
Genetic Disorders in Qatar....Pages 515-530
Genetic Disorders in Saudi Arabia....Pages 531-573
Genetic Disorders in Sudan....Pages 575-612
Front Matter....Pages 217-217
Genetic Disorders in Tunisia....Pages 613-638
Genetic Disorders in the United Arab Emirates....Pages 639-676
Genetic Disorders Among Jews from Arab Countries....Pages 677-702
Front Matter....Pages 703-703
Prevention and Care of Genetic Disorders: An Islamic Perspective....Pages 705-723
Genetic Counseling in the Middle East....Pages 725-740
Back Matter....Pages 741-772
