This second edition collects Nobel Prize winner Edward B. Lewis’s key publications in the fields of genetics, developmental biology, radiation and cancer. Editor Howard Lipshitz, a close colleague during the last 20 years of Lewis's life, places the papers in their scientific and historical context and provides insight into Lewis's approach to science and the motivations that drove his choice of subject matter.
Author(s): Howard D. Lipshitz
Edition: 2nd
Year: 2007
Language: English
Pages: 626
Contents......Page 8
Permissions......Page 12
Preface......Page 15
Preface to Second Edition......Page 17
INTRODUCTION......Page 20
Biographical Memoir......Page 29
SECTION I: GENES......Page 43
Background......Page 44
Invention of the cis–trans test for position effects......Page 45
Position pseudoalleles......Page 47
The bithorax pseudoalleles and the concept of developmental control......Page 49
Gene evolution by tandem duplication......Page 52
From cisvection to transvection......Page 53
Extending the bithorax pseudoalleleic series......Page 54
Genetic versus functional models......Page 56
From genes to gene complexes......Page 58
Star-recessive, a spontaneous mutation in Drosophila melanogaster Proceedings of the Minnesota Academy of Science 7:23–26......Page 61
Another case of unequal crossing over in Drosophila melanogaster Proceedings of the National Academy of Sciences USA 27:31–34......Page 65
The relation of repeats to position effect in Drosophila melanogaster Genetics, 30:137–166......Page 70
The pseudoallelism of white and apricot in Drosophila melanogaster Proceedings of the National Academy of Sciences USA 38:953–961......Page 100
Pseudoallelism and gene evolution. Cold Spring Harbor Symposia on Quantitative Biology, 16:159–174......Page 108
The theory and application of a new method of detecting chromosomal rearrangements in Drosophila melanogaster. American Naturalist, 88:225–239......Page 131
Some aspects of position pseudoallelism. American Naturalist, 89:73–89......Page 146
Genes and gene complexes. Heritage from Mendel, pp. 17–47......Page 163
SECTION II: GENES AND DEVELOPMENT......Page 189
Developmental genetics......Page 190
Gain-of-function and loss-of-function bithorax alleles, and the operon model......Page 193
Genetic mosaics: spatial and temporal aspects of bithorax function......Page 195
The 1978 paper: A paradigm for the genetic control of development......Page 197
Trans-acting regulators: positive and negative control of the homeotic complexes......Page 202
Cis-regulation within the BX-C: the rules of engagement......Page 204
Summary......Page 208
Genes and developmental pathways. American Zoologist, 3:33–56......Page 210
A gene complex controlling segmentation in Drosophila Nature, 276:565–570......Page 240
Genetic control of body segment differentiation in Drosophila. In: Developmental Order: Its Origin and Regulation. 40th Annual Symposium of the Society for Developmental Biology,......Page 254
Control of body segment differentiation in Drosophila by the bithorax gene complex. In: Embryonic Development, Part A: Genetic Aspects. Edited by M. M. Burger and R. Weber. Alan R. Liss, New York, pp. 269–288......Page 273
Regulation of the genes of the bithorax complex in Drosophila. Cold Spring Harbor Symposia on Quantitative Biology, 50:155–164......Page 289
SECTION III: MOLECULES AND DEVELOPMENT......Page 307
Positional cloning of the BX-C......Page 308
Completing the bithorax mutant series......Page 310
The molecular basis of developmental control......Page 311
Bithorax and the evolution of sexually dimorphic traits......Page 314
DNA sequence motifs in the cis-regulatory regions of the BX-C......Page 316
Evolution of the HOX complexes......Page 318
Summary......Page 319
Molecular genetics of the bithorax complex in Drosophila melanogaster. Science, 221:23–29......Page 320
The abdominal region of the bithorax complex Cell, 43:81–96......Page 336
Transabdominal, a dominant mutant of the bithorax complex, produces sexually dimorphic segmental transformation of Drosophila. Genes and Development, 1:111–123......Page 367
Molecular basis of Transabdominal—a novel sexually dimorphic mutant of the bithorax complex of Drosophila. Proceedings of the National Academy of Sciences USA, 90:1566–1570......Page 390
Sequence analysis of the cis-regulatory regions of the bithorax complex of Drosophila. Proceedings of the National Academy of Sciences USA, 92:8403–8407......Page 399
Splits in fruitfuly Hox gene complexes. Nature, 380:116......Page 409
Evolution of the homeobox complex in the Diptera. Current Biology, 13:R587–R588......Page 412
SECTION IV: RADIATION AND CANCER......Page 417
Genetic and somatic effects of ionizing radiation......Page 418
The political and social context......Page 419
Leukemia, multiple myeloma, and aplastic anemia in American radiologists. Science, 142:1492–1494......Page 459
Political fallout......Page 424
Thyroid radiation doses from weapons fallout......Page 430
Best estimates of risk: leukemia in populations exposed to low doses of radiation......Page 431
Summary......Page 433
Leukemia and ionizing radiation. Science, 125:965–972......Page 435
Thyroid radiation doses from fallout. Proceedings of the National Academy of Sciences, 45:894–897......Page 454
Ionizing radiation and tumor production. In: Genetic Concepts and Neoplasia, Williams & Wilkins Co, pp. 57–73......Page 467
Letters: Leukemia, radiation, and hyperthyroidism. Science, 174:454......Page 481
Analysis of lung tumor mortality in the Batelle Beagle Lifespan experiment. In: Health Effects of Alpha-Emitting Particles in the Respiratory Tract, Report of Ad Hoc Committee on "Hot Particles" of the Advisory Committee on the Biological Effects of Ionizing Radiations, National Academy of Sciences–National Research Council......Page 483
Ionizing radiation, cancer induction and radioactive fallout. In:Proceedings of the International Conference. The Discovery of Polonium and Radium—its scientific and philosophical consequences, benefits and threats to mankind. Polish Academy of Sciences, Warsaw, Poland, pp. 227–237......Page 494
SECTION V: HISTORICAL PERSPECTIVES......Page 502
Homeosis: the first 100 years. Trends in Genetics, 10:341–343......Page 503
Remembering Sturtevant. Genetics, 141:1227–1230......Page 509
C. B. Bridges' repeat hypothesis and the nature of the gene Genetics, 164:427–431......Page 515
Did Demerec discover intragenic recombination in 1928? Genetics 168:1785–1786......Page 524
Autobiographical sketch......Page 528
The bithorax complex: the first fifty years. Les Prix Nobel, 1995. Almquist & Wiksell International: Stockholm, Sweden, pp. 233–260......Page 535
APPENDIX......Page 560
Curriculum vitae......Page 561
References......Page 568
A......Page 575
B......Page 576
C......Page 577
D......Page 579
F......Page 580
G......Page 581
l......Page 582
L......Page 583
M......Page 584
P......Page 585
R......Page 586
S......Page 587
Z......Page 589
