Coedited by internationally recognized leaders in gene therapy research, this guide supplies the most recent advances, studies, and expert opinion on gene therapy for neurological disorders. Spanning conditions such as Parkinsons's and Alzheimer's disease, multiple sclerosis, brain tumors, stroke, epilepsy, and brain and spinal cord trauma, this reference presents the basic science and applications of recombinant gene products, immune and stem cell-mediated therapeutic strategies, and brain tumor gene therapy.
Author(s): R. Lowenstein Pedro, Maria G. Castro
Edition: 1
Publisher: Informa Healthcare
Year: 2006
Language: English
Pages: 382
Front Cover......Page 1
Half-title......Page 2
Insise cover......Page 4
Copyright......Page 5
Dedication......Page 6
Foreword......Page 8
Preface......Page 10
Acknowledgments......Page 16
Contents......Page 18
Contributors......Page 24
1. Immune Responses to Viral Vectors: Implications for Neurological Gene Therapy......Page 29
2. Gene Transfer to the Nerve System Using HSV-1-Derived Amplicon Vectors......Page 45
3. Adeno Associated Viral Vectors for the Nervous System......Page 61
4. Heat Shock Proteins for Neurological Gene Therapy......Page 67
5. iBAC Technologies for Neurological Disease......Page 87
6. Targeted Gene Modification of the Nervous System......Page 103
7. Astrocytes as Targets for Neurological Gene Therapy......Page 129
8. Non-viral Mediated Gene Delivery for Therapeutic Applications......Page 143
9. Gene Therapy Applications for Parkinson’s Disease......Page 169
10. HSV-Mediated Gene Transfer in the Treatment of Chronic Pain......Page 213
11. Immunotherapeutic Approaches for Alzheimer’s Disease......Page 225
12. Gene Therapy of Multiple Sclerosis and in CNS Autoimmune Mouse Models......Page 241
13. Novel Gene Therapeutic Approaches to Brain Cancer......Page 257
14. Vaccines and Beneficial Immunity in Glioma Patients......Page 293
15. Replicating Viruses for Brain Tumor Treatment......Page 321
16. Adenovirus-Mediated HSV-tk Gene Therapy for Malignant Glioma: Clinical Experience......Page 355
Index......Page 371
