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Gene Delivery Systems: Development and Applications

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This unique volume in our Drugs and Pharmaceutical Sciences series covers the development of gene therapy today, the technology involved, clinical applications of siRNA, non-viral vector-based mRNA delivery using nanotechnology, and RNA based vaccines for treating the infectious diseases. It also presents the current application of the CRISPR/Cas9 gene-editing technique which has revolutionized genome editing and which was awarded the 2020 Nobel Prize in Chemistry. Several new drug delivery systems are explored for the applications of gene therapy. These are found to be useful in treating chronic illnesses, including cancer and infectious diseases.

Key Features:

    • Overview of the development of gene therapy

    • Provides the most up to date information on the development of gene therapy, from the technology involved to gene correction and genome editing

    • Presents CRISPR gene therapy recent trends and applications

    • Discusses siRNA, mRNA, and DNA plasmids

    Author(s): Yashwant Pathak
    Series: Drugs and the Pharmaceutical Sciences
    Publisher: CRC Press
    Year: 2022

    Language: English
    Pages: 316
    City: Boca Raton

    Cover
    Half Title
    Series
    Title
    Copyright
    Dedication
    Contents
    Preface
    About the Editor
    List of Contributors
    Chapter 1 Overview of Development of Gene Therapy
    Chapter 2 Understanding the Technologies Involved in Gene Therapy
    Chapter 3 Gene Therapy and Gene Correction: Target, Progress and Challenges to Treat Human Diseases
    Chapter 4 Clinical Applications of siRNA
    Chapter 5 Human Genomics Projects, Gene Therapy and Precision Medicine
    Chapter 6 The Current State of Non­Viral Vector–Based mRNA Medicine Using Various Nanotechnology Applications
    Chapter 7 RNA­Based Vaccines for Infectious Disease
    Chapter 8 Conditional Replication of Oncolytic Virus Based on Detection of Oncogenic mRNA
    Chapter 9 Unilateral Ex Vivo Gene Therapy by GDNF in Neurodegenerative Diseases
    Chapter 10 Gene Therapy for Cancer Treatment: Recent Trends and Clinical Evidence
    Chapter 11 Gene Therapy for Retina and Eye Diseases
    Chapter 12 COVID­19 Vaccine Development and Applications
    Chapter 13 In Vivo Gene Therapy: AAV2 Vectors
    Chapter 14 Gene Therapy for Acquired Tissue Damage: Scope, Quality, Non­Clinical and Clinical Guidelines of Gene Therapy Medical Products
    Chapter 15 iMRI for Clinical Gene Therapy
    Index