Cancer gene therapy is a novel therapy that targets the underlying genetic defects in the cancer cell. Progress in this field has been rapid and gene therapy promises to further extend personalized cancer treatment. In this volume leading experts have contributed their experience in developing gene therapies for a variety of cancers. Translational gene therapy approaches are emphasized. Chapters include discussions of specific gene delivery technologies as well as their application to various cancers with extensive discussions of ongoing clinical trials. This information should be useful to students, fellows, clinical investigators, and experienced scientists with an interest in this rapidly developing area.
Author(s): Edna M. Mora, Selanere L. Mangala (auth.), Jack A. Roth (eds.)
Series: Current Cancer Research
Edition: 1
Publisher: Springer-Verlag New York
Year: 2010
Language: English
Pages: 278
Tags: Cancer Research; Pharmacology/Toxicology
Front Matter....Pages i-xiv
RNAi: A New Paradigm in Cancer Gene Therapy....Pages 1-15
Gene-Based Therapy for Cancer: Brain Tumors....Pages 17-32
Gene Therapy of Prostate Cancer....Pages 33-49
siRNA Versus shRNA for Personalized Cancer Therapy: Mechanisms and Applications....Pages 51-62
Tumor Suppressor Gene Therapy....Pages 63-78
Targeted Oncolytic Adenovirus for Human Cancer Therapy: Gene-Based Therapies for Cancer....Pages 79-93
Gene Therapy for Malignant Pleural Mesothelioma....Pages 95-111
Mesenchymal Stem/Stromal Cells as Cellular Vehicles for Tumor Targeting....Pages 113-139
Retargeting Adenovirus for Cancer Gene Therapy....Pages 141-153
Lentiviruses: Vectors for Cancer Gene Therapy....Pages 155-179
Interleukin-24 Gene Therapy for Melanoma....Pages 181-202
Herpes Simplex Virus 1 for Cancer Therapy....Pages 203-230
Telomerase as a Target for Cancer Therapeutics....Pages 231-249
Gene Therapy for Sarcoma....Pages 251-268
Back Matter....Pages 269-275
