Through the integration of bioinformatic, genetic, transcriptomic, proteomic, metabolomic, phenomic and other massive datasets, genomics is revealing exciting new insights into fungal cell biology. The central theme of this volume is the strong impact that genomics is having upon our understanding of fungal biology, across a wide range of species, including model yeasts (such as Saccharomyces cerevisiae and Schizosaccharomyces pombe), filamentous fungi (such as Neurospora crassa and Aspergillus nidulans) and pathogenic fungi (such as Magnaporthe grisae, Candida albicans, Cryptococcus neoformans and Histoplasma capsulatum). World-renowned scientists address the following topics in these fungi: systems biology and evolution, circadian rhythms, apoptosis and stress responses, secretion, and environmental signalling networks. Particular emphasis is placed on fungal pathogenicity. Various genomic technologies are discussed, including genome-wide sequence comparisons, transcript profiling, proteomics, metabolomics and bioinformatics.
Author(s): J.I. Castrillo, S.G. Oliver (auth.), Professor Dr. Alistair J.P. Brown (eds.)
Series: The Mycota 13
Publisher: Springer Berlin Heidelberg
Year: 2006
Language: English
Pages: XVIII, 275 p. 37 illus., 6 in color.
Tags: Microbial Genetics and Genomics; Plant Genetics & Genomics; Microbiology; Proteomics; Medical Microbiology
Metabolomics and Systems Biology in Saccharomyces cerevisiae ....Pages 3-18
Genome Evolution in Hemiascomycete Yeasts....Pages 19-34
Investigating the Evolution of Fungal Virulence by Functional Genomics....Pages 35-49
Circadian Rhythms, Photobiology and Functional Genomics in Neurospora ....Pages 53-74
Genomics of Protein Secretion and Hyphal Growth in Aspergillus ....Pages 75-96
The Genomics of Stress Response in Fission Yeast....Pages 97-111
Programmed Cell Death and Apoptosis in Fungi....Pages 113-146
Genomic Analysis of Cellular Morphology in Candida albicans ....Pages 147-159
Postgenomic Approaches to Analyse Candida albicans Pathogenicity....Pages 163-184
Integration of Metabolism with Virulence in Candida albicans ....Pages 185-203
Regulators of Candida glabrata Pathogenicity....Pages 205-219
Using Genomics to Study the Life Cycle of Histoplasma capsulatum ....Pages 221-236
Cryptococcus neoformans Pathogenicity....Pages 237-266