This important volume commences with an overview of the modes of action of defensive secondary metabolites, followed by detailed surveys of chemical defense in marine ecosystems, the biochemistry of induced defense, plant-microbe interactions and medical applications. A chapter is also included covering biotechnological aspects of producing valuable secondary metabolites in plant cell and organ cultures. This is a comprehensive and fully updated new edition, edited by Professor Michael Wink and including contributions from many internationally acknowledged experts in the field.
Author(s): Michael Wink
Edition: 2
Year: 2010
Language: English
Pages: 424
ANNUAL PLANT REVIEWS
VOLUME 39......Page 5
CONTENTS......Page 9
List of contributors......Page 11
Preface......Page 13
1.1 Ecological function of secondary metabolites......Page 17
1.2 Presence of defence and signal compounds at the right time and place......Page 20
1.3 Molecular modes of action of SM......Page 24
1.4 Biotechnology and utilization of SM......Page 29
1.5 Conclusions......Page 32
2.1 Introduction......Page 37
2.2 Molecular modes of action – an overview......Page 38
2.3 Accumulation of defence and signal compounds in plants......Page 151
2.4 Animal responses: detoxification mechanisms and adaptations......Page 155
2.5 Concluding remarks......Page 160
3.1 Introduction......Page 185
3.2 Marine natural products in allelopathic interactions......Page 188
3.3 Chemical defence against fouling......Page 191
3.4 Chemical defences of marine invertebrates and algae against consumers......Page 196
3.5 Favoured allocation of defensive metabolites in vulnerable and valuable parts of marine invertebrates and algae......Page 205
3.6 The flexible response: stress-induced accumulation of defence metabolites and activation of protoxins......Page 209
3.7 Endosymbionts as sources for allelochemicals found in marine invertebrates......Page 216
3.8 Conclusions and outlook......Page 224
4 Plant–Microbe Interactions and Secondary Metabolites with Antibacterial, Antifungal and Antiviral Properties......Page 237
4.1 Introduction......Page 238
4.2 Phytoalexins......Page 240
4.3 Antibacterial and antifungal agents of higher plants......Page 255
4.4 Secondary metabolites from higher plants with antiviral properties......Page 301
4.5 Conclusions......Page 340
5 New Medical Applications of Plant Secondary Metabolites......Page 371
5.2 Compounds with anticancer and chemopreventive activity......Page 372
5.3 Antiviral compounds......Page 382
5.4 Antimalarial drugs......Page 383
5.5 Anti-inflammatory drugs......Page 384
5.6 Antidepressant drugs......Page 386
5.7 Anti-ischaemic drugs......Page 387
5.8 Immunostimulatory drugs......Page 388
5.9 Conclusions......Page 389
6.1 Introduction......Page 404
6.3 Elicitation......Page 406
6.4 Increase/decrease of product yields by genetic manipulation......Page 407
6.5 Biosynthetic pathways delineation using RNA-interference......Page 408
6.6 Mass cultivation of plant cell cultures......Page 409
6.7 Production of recombinant proteins by plants and plant cell cultures......Page 411
6.8 Production of plant natural products in microbes......Page 412
6.9 Perspectives......Page 413
Index......Page 422
Colour plate (between pages 50 and 51)......Page 67
