The purpose of this work is to familiarize neuroscientists with the available tools for proteome research and their relative abilities and limitations. To know the identities of the thousands of different proteins in a cell, and the modifications to these proteins, along with how the amounts of both of these change in different conditions would revolutionize biology and medicine. While important strides are being made towards achieving the goal of global mRNA analysis, mRNA is not the functional endpoint of gene expression and mRNA expression may not directly equate with protein expression. There are many potential applications for proteomics in neuroscience: determination of the neuro-proteome, comparative protein expression profiling, post-translational protein modification profiling and mapping protein-protein interactions, to name but a few. Functional Genomics and Proteomics in Clinical Neuroscience will comment on all of these applications, but with an emphasis on protein expression profiling. This book combines the basic methodology of genomics and proteomics with the current applications of such technologies in understanding psychiatric illnesses. * Introduction of basic methodologies in genomics and proteomics and their integration in psychiatry * Development of the text in sections related to methods, application and future directions of these rapidly advancing technologies * Use of actual data to illustrate many principles of functional genomics and proteomics. * Introduction to bioinformatics and database management techniques
Author(s): S.E. Hemby and S. Bahn (Eds.)
Series: Progress in brain research 158
Edition: 1st ed
Publisher: Elsevier B. V
Year: 2006
Language: English
Commentary: 179839
Pages: 1-318
City: Boston, MA
Content:
List of Contributors
Pages v-vi
Foreword
Pages vii-viii
Stephen H. Koslow
Tissue preparation and banking Review Article
Pages 3-14
Maree J. Webster
Functional genomic methodologies Review Article
Pages 15-40
Stephen D. Ginsberg, Károly Mirnics
Methods for proteomics in neuroscience Review Article
Pages 41-82
Nilesh S. Tannu, Scott E. Hemby
Functional genomics and proteomics in the clinical neurosciences: data mining and bioinformatics Review Article
Pages 83-108
John H. Phan, Chang-Feng Quo, May D. Wang
Reproducibility of microarray studies: concordance of current analysis methods Review Article
Pages 109-125
Matt T. Wayland, Sabine Bahn
The genomics of mood disorders Review Article
Pages 129-139
Salvatore Alesci, Michelle Rodak, Ioannis Ilias, Rulun Zhou, Husseini K. Manji
Transcriptome alterations in schizophrenia: disturbing the functional architecture of the dorsolateral prefrontal cortex Review Article
Pages 141-152
David A. Lewis, Karoly Mirnics
Strategies for improving sensitivity of gene expression profiling: regulation of apoptosis in the limbic lobe of schizophrenics and bipolars Review Article
Pages 153-172
Francine M. Benes
Assessment of genome and proteome profiles in cocaine abuse Review Article
Pages 173-195
Scott E. Hemby
Neuronal gene expression profiling: uncovering the molecular biology of neurodegenerative disease Review Article
Pages 197-222
Elliott J. Mufson, Scott E. Counts, Shaoli Che, Stephen D. Ginsberg
Epileptogenesis-related genes revisited Review Article
Pages 223-241
Katarzyna Lukasiuk, Michal Dabrowski, Alicja Adach, Asla Pitkänen
Functional genomics of sex hormone-dependent neuroendocrine systems: specific and generalized actions in the CNS Review Article
Pages 243-272
Anna W. Lee, Nino Devidze, Donald W. Pfaff, Jin Zhou
Implications for the practice of psychiatry Review Article
Pages 275-293
Elisabeth B. Binder, Charles B. Nemeroff
Human brain evolution Review Article
Pages 295-309
Hilliary Creely, Philipp Khaitovich
Subject Index
Pages 311-317
Erratum to Progress in Brain Research Vol. 158 Functional Genomics and Proteomics in the Clinical Neurosciences Scott E. Hemby and Sabine Bahn
Page 318
