Functional Coherence of Molecular Networks in Bioinformatics

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Molecular networks provide descriptions of the organization of various biological processes, including cellular signaling, metabolism, and genetic regulation. Knowledge on molecular networks is commonly used for systems level analysis of biological function; research and method development in this area has grown tremendously in the past few years. This book will provide a detailed review of existing knowledge on the functional characterization of biological networks. In 15 chapters authored by an international group of prolific systems biology and bioinformatics researchers, it will organize, conceptualize, and summarize the existing core of research results and computational methods on understanding biological function from a network perspective.

Author(s): Mehmet Koyutürk, Shankar Subramaniam (auth.), Mehmet Koyutürk, Shankar Subramaniam, Ananth Grama (eds.)
Edition: 1
Publisher: Springer-Verlag New York
Year: 2012

Language: English
Pages: 228
Tags: Systems Biology; Computational Biology/Bioinformatics; Computer Science, general; Biomedical Engineering

Front Matter....Pages i-x
Introduction to Network Biology....Pages 1-13
Topological Characteristics of Molecular Networks....Pages 15-48
Function Annotation in Gene Networks....Pages 49-67
Proteome Network Emulating Models....Pages 69-95
Biological Network Alignment....Pages 97-136
Pattern Mining Across Many Massive Biological Networks....Pages 137-170
Molecular Networks and Complex Diseases....Pages 171-199
Moving Toward Genome-Scale Kinetic Models: The Mass Action Stoichiometric Simulation Approach....Pages 201-220
Back Matter....Pages 221-228