The book covers major advances made in cellular bioenergetics, a central topic in biological and medical research. The chapters, contributed by authors representing major groups working in the field, extend from the latest advancements in X-ray crystallographic analysis of the atomic structure of energy transfer membrane proteins and analysis of their mechanism of action, to perspectives on the implication of their genetic and phenotypic defects in human diseases. The book, intended for researchers, clinicians and students aims at providing an up-to-date appraisal of this rapidly developing biomedical field.
The book consists of thirty-one chapters contributed by leading experts in the field of cellular bioenergetics. Three sections cover the X-ray crystallographic analysis, mutational analysis and mechanism of action of mitochondrial and prokaryotic respiratory enzymes, ATP synthase and mitochondrial carriers. One section deals with genetics and biogenesis of mitochondria. The fourth section covers genetic and phenotypic defects in mitochondrial energy transfer proteins associated with inborn and/or degenerative human diseases and aging.
Author(s): Peter Nicholls (auth.), Sergio Papa, Ferruccio Guerrieri, Joseph M. Tager (eds.)
Edition: 1
Publisher: Springer US
Year: 1999
Language: English
Pages: 801
Tags: Biochemistry, general; Pathology
Front Matter....Pages i-xxx
The Mitochondrial and Bacterial Respiratory Chains....Pages 1-22
The Mitochondrial Enzymes of Oxidative Phosphorylation....Pages 23-47
Proton Pumps of Respiratory Chain Enzymes....Pages 49-87
Uncoupling of Respiration and Phosphorylation....Pages 89-118
Crystallization, Structure, and Possible Mechanism of Action of Cytochrome c Oxidase from the Soil Bacterium Paracoccus denitrificans ....Pages 119-130
The Structure of Crystalline Bovine Heart Cytochrome c Oxidase....Pages 131-156
Electron and Proton Transfer in Heme-Copper Oxidases....Pages 157-178
Mechanism of Proton-Motive Activity of Heme-Copper Oxidases....Pages 179-192
Oxygen Reduction and Proton Translocation by the Heme-Copper Oxidases....Pages 193-217
Transient Spectroscopy of the Reaction between Cytochrome c Oxidase and Nitric Oxide....Pages 219-232
Energy Transduction in Mitochondrial Respiration by the Proton-Motive Q-Cycle Mechanism of the Cytochrome bc 1 Complex....Pages 233-261
The Crystal Structure of Mitochondrial Cytochrome bc 1 Complex....Pages 263-289
Structural Aspects of the Cytochrome bc 1 Complex....Pages 291-324
Structure, Function, and Biogenesis of Respiratory Complex I....Pages 325-360
Structure of F 1 -ATPase and the Mechanism of ATP Synthesis— Hydrolysis....Pages 361-376
Mechanism of ATP Synthesis by Mitochondrial ATP Synthase....Pages 377-398
Mutational Analysis of ATP Synthase An Approach to Catalysis and Energy Coupling....Pages 399-421
Analysis of the Nucleotide Binding Sites of ATP Synthase and Consequences for the Catalytic Mechanism....Pages 423-457
Coupling Structures and Mechanisms in the Stalk of the Bovine Mitochondrial F 0 F 1 -ATP Synthase....Pages 459-487
The Mitochondrial Carrier Protein Family....Pages 489-519
Structure and Evolution of Metazoan Mitochondrial Genome....Pages 521-551
Nuclear Transcription Factors in Cytochrome c and Cytochrome Oxidase Expression....Pages 553-591
Suppressor Genetics of the Mitochondrial Energy Transducing System The Cytochrome bc 1 Complex....Pages 593-619
Tissue-Specific Expression of Cytochrome c Oxidase Isoforms and Role in Nonshivering Thermogenesis....Pages 621-633
Mitochondrial DNA Mutations and Nuclear Mitochondrial Interactions in Human Disease....Pages 635-663
Strategy toward Gene Therapy of Mitochondrial DNA Disorders....Pages 665-675
The F 0 F 1 -ATP Synthase in Cell Proliferation and Aging....Pages 677-692
Age-Linked Changes in the Genotype and Phenotype of Mitochondria....Pages 693-727
Nucleus-Driven Lesions of mtDNA and Disorders of Nucleus-Encoded Energy Genes....Pages 729-749
Aging and Degenerative Diseases....Pages 751-772
Perspectives on the Permeability Transition Pore, a Mitochondrial Channel Involved in Cell Death....Pages 773-795
Back Matter....Pages 797-801
