Harvard Medical School, Boston, MA. Text explores cell signal transduction pathways of particular importance to human cancer. Emphasis is placed on receptors at the cell surface, intracellular signaling cascades, transcription factors functioning in the nucleus, and pathways triggering programs of cell death.
Author(s): David A. Frank
Series: Cancer Treatment and Research
Edition: 1
Publisher: Springer
Year: 2002
Language: English
Pages: 366
Cover Page......Page 1
Title from Series "Cancer Treatment and Research"......Page 3
Inside Cover......Page 4
ISBN, Copyright......Page 5
Contents......Page 6
Preface......Page 8
GROWTH, SURVIVAL AND MIGRATION: THE TRK TO CANCER......Page 10
THE ROLE OF GROWTH FACTOR SIGNALING IN MALIGNANCY......Page 28
TGF-beta SIGNALING ALTERATIONS IN CANCER......Page 82
NOTCH IN MALIGNANCY......Page 104
cAMP SIGNALING IN CANCER GENESIS AND TREATMENT......Page 132
PI3K/PTEN/AKT PATHWAY - A critical mediator of oncogenic signaling......Page 154
WNT SIGNALING IN HUMAN CANCER......Page 178
RAS SIGNALING, DEREGULATION OF GENE EXPRESSION AND ONCOGENESIS......Page 198
ROLE OF THE RB TUMOR SUPPRESSOR IN CANCER......Page 218
THE Rel/NF-kappaB/I-kappaB SIGNAL TRANSDUCTION PATHWAY AND CANCER......Page 250
STAT SIGNALING IN CANCER: INSIGHTS INTO PATHOGENESIS AND TREATMENT STRATEGIES......Page 276
STEROID HORMONE RECEPTOR SIGNALING IN CANCER......Page 302
CELL DEATH SIGNALING IN MALIGNANCY......Page 328
CERAMIDE AND SPHINGOSINE 1-PHOSPHATE IN ANTI-CANCER THERAPIES......Page 354
INDEX......Page 364
