Evolutionary Bioinformatics

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Evolutionary Bioinformatics aims to make the "new" information-based (rather than gene-based) bioinformatics intelligible both to the "bio" people and the "info" people. Books on bioinformatics have traditionally served gene-hunters, and biologists who wish to construct family trees showing tidy lines of descent. While dealing extensively with the exciting topics of gene discovery and database-searching, such books have hardly considered genomes as information channels through which multiple forms and levels of information have passed through the generations. This "new bioinformatics," contrasts with the "old" gene-based bioinformatics that so preoccupies previous texts. Evolutionary Bioinformatics extends a line of evolutionary thought that leads from the nineteenth century (Darwin, Butler, Romanes, Bateson), through the twentieth (Goldschmidt, White), and into the twenty first (the final works of the late Stephen Jay Gould). Long an area of controversy, diverging views may now be reconciled. The book is unique in emphasising non-genic aspects of bioinformatics, and linking modern evolutionary biology to a history that extends back to the nineteenth century. Forms of information that we are familiar with (mental, textual) are related to forms we are less familiar with (hereditary).

Author(s): Donald R. Forsdyke (auth.)
Edition: 2
Publisher: Springer-Verlag New York
Year: 2011

Language: English
Pages: 509
Tags: Bioinformatics; Evolutionary Biology; Animal Genetics and Genomics; Proteomics; Statistics for Life Sciences, Medicine, Health Sciences; Human Genetics

Front Matter....Pages i-xxii
Front Matter....Pages 1-1
Memory – A Phenomenon of Arrangement....Pages 3-26
Chargaff’s First Parity Rule....Pages 27-45
Information Levels and Barriers....Pages 47-66
Front Matter....Pages 67-67
Chargaff’s Second Parity Rule....Pages 69-90
Stems and Loops....Pages 91-109
Chargaff’s Cluster Rule....Pages 111-127
Front Matter....Pages 129-129
Mutation....Pages 131-151
Species Survival and Arrival....Pages 153-169
The Weak Point....Pages 171-188
Chargaff’s GC rule....Pages 189-204
Homostability....Pages 205-218
Front Matter....Pages 219-219
Conflict Resolution....Pages 221-247
Exons and Introns....Pages 249-266
Complexity....Pages 267-291
Front Matter....Pages 293-293
Self/Not-Self?....Pages 295-318
The Crowded Cytosol....Pages 319-337
Front Matter....Pages 339-339
Rebooting the Genome....Pages 341-361
The Fifth Letter....Pages 363-374
Front Matter....Pages 375-375
Memory – What is Arranged and Where?....Pages 377-389
Back Matter....Pages 391-509