Focusing on practical, patient related issues, this volume provides the basic concepts of Evidence Based Medicine (EBM) as they relate to Pathology and Laboratory Medicine and presents various practical applications. It includes EBM concepts for use in the identification of cost-effective panels of immunostains and other laboratory tests and for improvement of diagnostic accuracy based on the identification of selected diagnostic features for particular differential diagnosis. EBM concepts are also put forth for use in Meta-analysis to integrate the results of conflicting literature reports and use of novel analytical tools such as Bayesian belief networks, neural networks, multivariate statistics and decision tree analysis for the development of new diagnostic and prognostic models for the evaluation of patients. This volume will be of great value to pathologists who will benefit from the concepts being promoted by EBM, such as levels of evidence, use of Bayesian statistics to develop diagnostic and other rules and stronger reliance on "hard data" to support therapeutic and diagnostic modalities.
Author(s): Alberto M. Marchevsky, Mark R. Wick (auth.), Alberto M. Marchevsky, Mark Wick (eds.)
Edition: 1
Publisher: Springer-Verlag New York
Year: 2011
Language: English
Pages: 361
Tags: Pathology; Laboratory Medicine; Health Administration
Front Matter....Pages i-xiv
Front Matter....Pages 1-1
Introduction to Evidence-Based Pathology and Laboratory Medicine....Pages 3-17
Evidence-Based Pathology: A Stable Set of Principles for a Rapidly Evolving Specialty....Pages 19-25
What Is Best Evidence in Pathology?....Pages 27-39
Biostatistics 101....Pages 41-60
Prognostication and Prediction in Anatomic Pathology: Carcinoma of the Breast as an Illustrative Model....Pages 61-93
Principles of Classification and Diagnosis in Anatomic Pathology and the Inevitability of Problem Cases....Pages 95-120
Evaluating Oncopathological Studies: The Need to Evaluate the Internal and External Validity of Study Results....Pages 121-140
Power Analysis and Sample Sizes in Pathology Research....Pages 141-148
Meta-Analysis: A Statistical Method to Integrate Information Provided by Different Studies....Pages 149-171
Decision Analysis and Decision Support Systems in Anatomic Pathology....Pages 173-186
Front Matter....Pages 187-187
Evidence-Based Approach to Evaluate Information Published in the Pathology Literature and Integrate It with Personal Experience....Pages 189-201
Evidence-Based Cell Pathology Revisited: A Personal View....Pages 203-211
Development of Evidence-Based Diagnostic Criteria and Prognostic/Predictive Models: Experience at Cedars Sinai Medical Center....Pages 213-234
Evaluation and Reduction of Diagnostic Errors in Pathology Using an Evidence-Based Approach....Pages 235-244
Meta-Analysis 101 for Pathologists....Pages 245-259
Evidence-Based Practices in Applied Immunohistochemistry: Dilemmas Caused by Cross-Purposes....Pages 261-295
Evidence-Based Pathology and Laboratory Medicine in the Molecular Pathology Era: Transition of Tests from the Research Bench into Practice....Pages 297-304
The Use of Decision Analysis Tools for the Selection of Clinical Laboratory Tests: Developing Diagnostic and Forecasting Models Using Laboratory Evidence....Pages 305-322
Implementation and Benefits of Computerized Physician Order Entry and Evidence-Based Clinical Decision Support Systems....Pages 323-335
Evidence-Based Pathology and Tort Law: How Do They Compare?....Pages 337-348
Back Matter....Pages 349-361
