InTech, 2011. — 552 p.This book about Parkinson’s disease provides a detailed account of etiology and pathophysiology of Parkinson’s disease, a complicated neurological condition. Environmental and genetic factors involved in the causation of Parkinson’s disease have been discussed in detail. This book can be used by basic scientists as well as researchers. Neuroscience fellows and life science readers can also obtain sufficient information. Beside genetic factors, other pathophysiological aspects of Parkinson’s disease have been discussed in detail. Up to date information about the changes in various neurotransmitters, inflammatory responses, oxidative pathways and biomarkers has been described at length. Each section has been written by one or more faculty members of well known academic institutions. Thus, this book brings forth both clinical and basic science aspects of Parkinson’s disease.Contents
Etiology and Pathogenesis of Parkinson’s Disease
Genetics of Parkinson Disease
Parkin and Parkinson’s Disease
Modeling LRRK2 Parkinsonism
Alpha-Synuclein Interactions with Membranes
Alpha-Synuclein, Oxidative Stress and Autophagy Failure: Dangerous Liaisons in Dopaminergic Neurodegeneration
Targeting α-Synuclein-Related Synaptic Pathology: Novel Clues for Parkinson’s Disease Therapy
Effects of Alpha-Synuclein on Cellular Homeostasis
Actions of GDNF on Midbrain Dopaminergic Neurons: The Signaling Pathway
The Hsp70 Chaperone System in Parkinson’s Disease
The Noradrenergic System is a Major Component in Parkinson’s Disease
The Energy Crisis in Parkinson’s Disease: A Therapeutic Target
Analysis of Transcriptome Alterations in Parkinson’s Disease
Brain Mitochondrial Dysfunction and Complex I Syndrome in Parkinson´s Disease
Role of Microglia in Inflammatory Process in Parkinson’s Disease
Oxidative DNA Damage and the Level of Biothiols, and L-Dopa Therapy in Parkinson’s Disease
Inflammatory Responses and Regulation in Parkinson’s Disease
Mathematical Models: Interactions Between Serotonin and Dopamine in Parkinson’s Disease
Dopaminergic Control of the Neurotransmitter Release in the Subthalamic Nucleus: Implications for Parkinson’s Disease Treatment Strategies
Possible Contribution of the Basal Ganglia Brainstem System to the Pathogenesis of Parkinson’s Disease
Role of Lysosomal Enzymes in Parkinson’s Disease: Lesson from Gaucher’s Disease
Physiological and Biomechanical Analyses of Rigidity in Parkinson's Disease
Mesothalamic Dopaminergic Activity: Implications in Sleep Alterations in Parkinson's Disease
Pathophysiology of Non-Dopaminergic Monoamine Systems in Parkinson's Disease: Implications for Mood Dysfunction
