This book provides a comprehensive approach to an understanding of all clinical conditions where estrogens and progestogens are involved. It encompasses the underlying science of chemistry, physiology, biochemistry and pharmacology. There is a broad but detailed perspective on the clinical use of estrogens and progestogens in therapy, contraception and hormone replacement therapy. An international line up of contributors provide an up-to-date world view on this subject.
Author(s): Ian S. Fraser; Robert Jansen; Rogerio A. Lobo; Malcolm I. Whitehead
Publisher: Churchill Livingstone
Year: 1998
Language: English
Commentary: From archive.org: https://archive.org/details/estrogensprogest0000unse
Pages: 909
City: London
Front Cover
Dedications
Title Page
Copyright
Contents
Contributors
Foreword
Preface
Glossary
1: Historical overview
1: The discovery of reproductive steroid hormones and recognition of their physiological roles (Diczfalusy & Fraser)
2: Historical overview of estrogens and progestogens as therapeutic agents (Goldzieher)
3: Drug regulatory testing (Edgren)
2: Chemistry
4: Structure-function relationships and metabolism of estrogens and progestogens (Stanczyk)
5: Chemistry of antihormones (Davies)
6: Chemical synthesis (Edwards & Henzl)
3: Physiology
7: Biosynthesis and secretion of ovarian and adrenal steroids (Hillier)
8: Metabolism of estrogens and progestogens (Longcope)
9: Feedback mechanisms (Baird)
10: The normal menstrual cycle; changes throughout life (Norman & Phillipson)
11: Action of estrogen and progesterone at the cellular level (Christin-Maitre, Chabbert-Buffet, & Bouchard)
12: The molecular basis for the development of estrogen, and progesterone agonists and antagonists (McDonnell & Wagner)
13: Effects of estrogen and progesterone on the endometrium (Critchley & Healy)
14: Menstruation (Rogers)
15: Effects of estrogen and progesterone on myometrium, cervix, fallopian tube, vagina and vulva (Jansen)
16: Effects of estrogen and progesterone on the breast (Hindle)
17: Effects of estrogen and progesterone on the central nervous system (Polcz, Horvath, & Naftolin)
18: Effects of estrogen and progesterone on bone (Winding, Jørgensen, & Christiansen)
19: Vascular effects of estrogen and progesterone (Miller, Prakash, Sieck, & Fitzpatrick)
20: Estrogen and progesterone effects on nonreproductive tissues: urinary tract (Johnston & Stanton)
21: Effects of estrogen and progesterone on skin (Brincat & Formosa)
22: Estrogen and progesterone during pregnancy and parturition (Challis & Lye)
23: Estrogens and progesterone in the post-partum period (Illingworth & McNeilly)
24: Estrogen and progesterone in the fetus and neonate (Carr)
4: Pharmacology
25: Pharmacokinetics of estrogens and progestogens (Faigle & Schenkel)
26: Pharmacodynamic effects of estrogens and progestogens (Goldzieher)
27: The pharmacology of antiestrogens and antiprogestogens (Davies)
5: Laboratory assessment
28: Assays for estrogens and progestogens (Collins)
29: Imaging of the reproductive tract (Ramsay & Fraser)
6: Therapeutics
30: Primary and secondary amenorrhea (Lobo)
31: Primary dysmenorrhea (Åkerlund)
32: Secondary dysmenorrhea and chronic pelvic pain (Odukoya, Atinson, & Cooke)
33: Premenstrual syndrome (Keye)
34: Polycystic ovary syndrome (PCOS) (Lobo)
35: Dysfunctional uterine bleeding (Fraser & Hickey)
36: Defective luteal function (Lessey & Fritz)
37: Endometriosis and adenomyosis (Barbieri)
38: Leiomyomata (Vollenhoven & Healy)
39: The pathophysiology and therapy of benign breast disease (Fentiman)
40: Precocious puberty (Dattani & Brook)
41: Assisted reproductive technologies (Lobo)
42: Use of therapeutic steroids in pregnancy (Matson & Yovich)
43: Fetal effects of estrogens, progestogens and diethylstilbestrol (Simpson & Kaufman)
44: Clinical aspects of oral contraception (Connell)
45: Clinical aspects of the use of long-acting hormonal contraception (Weisberg & Fraser)
46: Antiprogestogens for contraception, interception and medical termination of pregnancy (Norman & Cameron)
47: Demographic aspects (McKinlay & Crawford)
48: Pituitary and ovarian changes (Burger)
49: Hot flashes (Brzechffa & Judd)
50: Psychological effects of menopause (Liao & Hunter)
51: Pharmacological background of estrogen replacement therapy and menopause (Hammond & Blohm)
52: General principles of administration of hormone replacement therapy: indications and contraindications, routes of administration, treatment schedules (Whitehead)
53: Benefits of treatment: local and general menopausal symptoms (Lumsden)
54: Benefits of treatment: osteoporosis (Melton & Khosla)
55: Effects of hormone replacement therapy on the cardiovascular system (McCrohon & Celermajer)
56: Progestogen therapy in malignant tumors of the uterus and ovary (Felix & Kurman)
57: Use of estrogens and progestogens in women with breast cancer (Eden)
58: Sex steroid production from ovarian tumors (Jansen)
59: An overview of side effects (Darney)
60: Non-therapeutic beneficial effects (Kovacs)
61: Effects on carbohydrate metabolism (Godsland)
62: Effects of estrogens and progestogens on plasma lipids and lipoproteins (Crook)
63: Effects on the immunological system (Jones)
64: Psychological, mood and central nervous system effects (Panay, Sands, & Studd)
65: Psychosexual effects (Dennerstein)
66: Effects on other tissues (Goldzieher)
67: The influence of steroids on gynecologic cancers (Schlesselman & Collins)
68: Influence of therapeutic steroids on the incidence and severity of breast cancer (Hankinson & Stampfer)
Index
Back Cover
