Mesenchymal stem cells (MSCs), a type of adult stem cells, have attracted the attention of scientists and physicians alike due to their unique biological properties and potential for disease treatment. As stem cell research is complex and progressing rapidly, it is important that the experts in this field share their views and perspectives. This book, co-edited by leading global researchers, is divided into three major sections and covers a broad range of topics concerning MSCs during their transition from benchside to bedside. The book is intended for researchers and clinicians in the field of stem cells. Dr. Robert Chunhua Zhao, MD. Ph.D is Cheung Kong Professor of Stem Cell Biology, Professor of Cell Biology at the Institute of Basic Medical Sciences & School of Basic Medicine, Chinese Academy of Medical Sciences & Peking Union Medical College, China Director of Center for Tissue Engineering, PUMC Chief scientist of 973 program Regional Editor of Stem Cells and Development.
Author(s): Shihua Wang, Robert Chunhua Zhao (auth.), Robert Chunhua Zhao (eds.)
Edition: 1
Publisher: Springer Netherlands
Year: 2013
Language: English
Pages: 313
Tags: Cell Biology; Stem Cells; Internal Medicine; Pathology
Front Matter....Pages i-viii
Front Matter....Pages 1-1
A Historical Overview and Concepts of Mesenchymal Stem Cells....Pages 3-15
Biology of MSCs Isolated from Different Tissues....Pages 17-32
Secretome of Mesenchymal Stem Cells....Pages 33-46
Immunomodulatory Properties of Mesenchymal Stem Cells and Related Applications....Pages 47-62
Mesenchymal Stem Cell Homing to Injured Tissues....Pages 63-74
Major Signaling Pathways Regulating the Proliferation and Differentiation of Mesenchymal Stem Cells....Pages 75-100
MicroRNAs in Mesenchymal Stem Cells....Pages 101-126
Genetic Modification of MSCs for Pharmacological Screening....Pages 127-138
Control of Mesenchymal Stem Cells with Biomaterials....Pages 139-159
Front Matter....Pages 161-161
Mesenchymal Stem Cells for Cardiovascular Disease....Pages 163-172
Mesenchymal Stem Cells as Therapy for Graft Versus Host Disease: What Have We Learned?....Pages 173-190
Mesenchymal Stem Cells for Liver Disease....Pages 191-197
Mesenchymal Stem Cells for Bone Repair....Pages 199-205
Mesenchymal Stem Cells for Diabetes and Related Complications....Pages 207-227
Mesenchymal Stromal Cell (MSC) Therapy for Crohn’s Disease....Pages 229-240
The Summary of Stroke and Its Stem Cell Therapy....Pages 241-252
Mesenchymal Stem Cell Transplantation for Systemic Lupus Erythematosus....Pages 253-261
Front Matter....Pages 263-263
Considerations of Quality Control Issues for the Mesenchymal Stem Cells-Based Medicinal Products....Pages 265-278
Regulations/Ethical Guidelines on Human Adult/Mesenchymal Stem Cell Clinical Trial and Clinical Translation....Pages 279-313
