Cover
Title Page
Copyright Page
Text and Illustration Team
Preface
Contents
1 An Introduction to Anatomy and Physiology
An Introduction to Studying the Human Body
1-1 All living things display responsiveness, growth, reproduction, movement, and metabolism
1-2 Anatomy is structure, and physiology is function
Anatomy
Physiology
1-3 Levels of organization progress from atoms and molecules to a complete organism
1-4 The human body consists of 11 organ systems
1-5 Homeostasis is the state of internal balance
1-6 Negative feedback opposes variations from normal, whereas positive feedback exaggerates them
Negative Feedback
Positive Feedback
1-7 Anatomical terms describe body regions, anatomical positions and directions, and body sections
Surface Anatomy
Sectional Anatomy
1-8 Body cavities of the trunk protect internal organs and allow them to change shape
The Thoracic Cavity
The Abdominopelvic Cavity
SPOTLIGHT
Levels of Organization
CLINICAL NOTES
Homeostasis and Disease
Imaging Techniques
Chapter Review
2 The Chemical Level of Organization
An Introduction to the Chemical Level of Organization
2-1 Atoms are the basic particles of matter
Atomic Structure
Isotopes
Atomic Weight
Electron Shells
2-2 Chemical bonds are forces formed by interactions between atoms
Ionic Bonds
Covalent Bonds
Hydrogen Bonds
2-3 Decomposition, synthesis, and exchange reactions are important chemical reactions in physiology
Basic Energy Concepts
Types of Reactions
Reversible Reactions
2-4 Enzymes catalyze specific biochemical reactions by lowering a reaction's activation energy
2-5 Inorganic compounds usually lack carbon, and organic compounds always contain carbon
2-6 Physiological systems depend on water
2-7 Body fluid pH is vital for homeostasis
2-8 Acids, bases, and salts have important physiological roles
Salts
Buffers and pH
2-9 Carbohydrates contain carbon, hydrogen, and oxygen in a 1:2:1 ratio
Monosaccharides
Disaccharides and Polysaccharides
2-10 Lipids contain a carbon-to-hydrogen ratio of 1:2
Fatty Acids
Fats
Steroids
Phospholipids
2-11 Proteins contain carbon, hydrogen, oxygen, and nitrogen and are formed from amino acids
Protein Function
Protein Structure
Enzyme Function
2-12 DNA and RNA are nucleic acids
Structure of Nucleic Acids
2-13 ATP is a high-energy compound used by cells
2-14 Chemicals form functional units called cells
SPOTLIGHT
Chemical Notation
CLINICAL NOTE
Too Sweet on Sugar?
Chapter Review
3 Cell Structure and Function
An Introduction to Cell Structure and Function
3-1 The study of cells provides the foundation for understanding human physiology
The Study of Cells
An Overview of Cell Anatomy
3-2 The plasma membrane separates the cell from its surrounding environment and performs various functions
Membrane Lipids
Membrane Proteins
Membrane Carbohydrates
3-3 Diffusion is a passive transport process that assists membrane passage
Diffusion
3-4 Carrier-mediated and vesicular transport processes assist membrane passage
Carrier-Mediated Transport
Vesicular Transport
3-5 Organelles within the cytoplasm perform specific functions
The Cytosol
The Organelles
3-6 The nucleus contains DNA and enzymes essential for controlling cellular activities
Nuclear Structure and Contents
Information Storage in the Nucleus
3-7 DNA controls protein synthesis, cell structure, and cell function
Transcription
Translation
3-8 Stages of a cell's life cycle include interphase, mitosis, and cytokinesis
Interphase
Mitosis
Cytokinesis
3-9 Tumors and cancers are characterized by abnormal cell growth and division
3-10 Cellular differentiation is cellular specialization as a result of gene activation or repression
SPOTLIGHT
Anatomy of a Model Cell
Protein Synthesis, Processing, and Packaging
CLINICAL NOTES
Inheritable Mitochondrial Disorders
DNA Fingerprinting
Mutations and Mosaicism
Chapter Review
4 The Tissue Level of Organization
An Introduction to the Tissue Level of Organization
4-1 The four tissue types are epithelial, connective, muscle, and nervous
4-2 Epithelial tissue covers body surfaces, lines cavities and tubular structures, and serves essential functions
Functions of Epithelia
Intercellular Connections
The Epithelial Surface
The Basement Membrane
Epithelial Renewal and Repair
4-3 Cell shape and number of layers determine the classification of epithelia
Cell Layers
Cell Shapes
Classification of Epithelia
Glandular Epithelia
4-4 Connective tissue provides a protective structural framework for other tissue types
Connective Tissue Proper
Types of Connective Tissue Proper
Fluid Connective Tissues
Supporting Connective Tissues
4-5 Tissue membranes are physical barriers of four types: mucous, serous, cutaneous, and synovial
Mucous Membranes
Serous Membranes
The Cutaneous Membrane
Synovial Membranes
4-6 The three types of muscle tissue are skeletal, cardiac, and smooth
Skeletal Muscle Tissue
Cardiac Muscle Tissue
Smooth Muscle Tissue
4-7 Nervous tissue responds to stimuli and propagates electrical impulses throughout the body
4-8 The response to tissue injury involves inflammation and regeneration
4-9 With advancing age, tissue repair declines and cancer rates increase
Aging and Tissue Structure
Aging and Cancer Rates
SPOTLIGHT
Inflammation and Regeneration
CLINICAL NOTES
Exfoliative Cytology
Marfan Syndrome
Adipose Tissue and Weight Control
Cartilages and Joint Injuries
Chapter Review
5 The Integumentary System
An Introduction to the Integumentary System
5-1 The epidermis is composed of strata (layers) with various functions
Stratum Basale
Intermediate Strata
Stratum Corneum
5-2 Epidermal pigmentation and dermal circulation influence skin color
The Role of Pigmentation
The Role of Dermal Circulation
5-3 Sunlight has beneficial and detrimental effects on the skin
The Epidermis and Vitamin D3
Skin Cancers
5-4 The dermis is the tissue layer that supports the epidermis
5-5 The subcutaneous layer connects the dermis to underlying tissues
5-6 Hair is composed of dead, keratinized cells that have been pushed to the skin surface
The Structure of Hair and Hair Follicles
Functions of Hair
Hair Color
5-7 Sebaceous glands and sweat glands are exocrine glands found in the skin
Sebaceous (Oil) Glands
Sweat Glands
5-8 Nails are keratinized epidermal cells that protect the tips of fingers and toes
5-9 After an injury, the integument is repaired in several phases
Repair of Skin Injuries
Effects of Burns
5-10 Effects of aging include dermal thinning, wrinkling, and reduced melanocyte activity
SPOTLIGHT
The Epidermis
CLINICAL NOTES
Drug Administration through the Skin
Disorders of Keratin Production
Dermatitis
Hair Loss
Burns
Chapter Review
6 The Skeletal System
An Introduction to the Skeletal System
6-1 The skeletal system has five major functions
6-2 Bones are classified according to shape and structure
Macroscopic Features of Bone
Microscopic Features of Bone
6-3 Ossification and appositional growth are processes of bone formation and enlargement
Intramembranous Ossification
Endochondral Ossification
Bone Growth and Body Proportions
Requirements for Normal Bone Growth
6-4 Bone growth and development depend on a balance between bone formation and resorption, and on calcium availability
The Role of Remodeling in Support
The Skeleton as a Calcium Reserve
Repair of Fractures
6-5 Osteopenia has a widespread effect on aging skeletal tissue
6-6 The bones of the skeleton are distinguished by bone markings and grouped into two skeletal divisions
Bone Markings (Surface Features)
Skeletal Divisions
6-7 The bones of the skull, vertebral column, and thoracic cage make up the axial skeleton
The Skull
The Vertebral Column and Thoracic Cage
6-8 The pectoral girdles and upper limb bones, and the pelvic girdle and lower limb bones, make up the appendicular skeleton
The Pectoral Girdles
The Upper Limb
The Pelvic Girdle
The Lower Limb
6-9 Joints are categorized according to their range of motion or anatomical organization
Immovable Joints (Synarthroses)
Slightly Movable Joints (Amphiarthroses)
Freely Movable Joints (Diarthroses)
6-10 The structure and functions of synovial joints enable various skeletal movements
Types of Movements at Synovial Joints
Types of Synovial Joints
6-11 Intervertebral joints and appendicular joints demonstrate functional differences in support and mobility
Intervertebral Joints
Joints of the Upper Limb
Joints of the Lower Limb
6-12 The skeletal system supports and stores energy and minerals for other body systems
SPOTLIGHT
Synovial Joints
CLINICAL NOTES
Types of Fractures and Steps in Repair
Osteoporosis
Rheumatism and Arthritis
Hip Fractures
Chapter Review
7 The Muscular System
An Introduction to Muscle Tissue
7-1 Skeletal muscle performs five primary functions
7-2 A skeletal muscle contains muscle tissue, connective tissues, blood vessels, and nerves
Connective Tissue Organization
Blood Vessels and Nerves
7-3 Skeletal muscle fibers have distinctive features
The Sarcolemma and Transverse Tubules
Myofibrils
The Sarcoplasmic Reticulum
Sarcomeres
7-4 The nervous system and skeletal muscles communicate at neuromuscular junctions
The Neuromuscular Junction
The Contraction Cycle
7-5 Sarcomere shortening and muscle fiber stimulation produce tension
Frequency of Muscle Fiber Stimulation
Number of Muscle Fibers Activated
Isotonic and Isometric Contractions
Muscle Elongation Following Contraction
7-6 ATP is the energy source for muscle contraction
ATP and CP Reserves
ATP Generation
Energy Use and the Level of Muscle Activity
Muscle Fatigue
The Recovery Period
7-7 Muscle performance depends on muscle fiber type and physical conditioning
Types of Skeletal Muscle Fibers
Physical Conditioning
7-8 Cardiac and smooth muscle tissues differ in structure and function from skeletal muscle tissue
Cardiac Muscle Tissue
Smooth Muscle Tissue
7-9 Descriptive terms are used to name skeletal muscles
Origins, Insertions, and Actions
Names of Skeletal Muscles
7-10 Axial muscles are muscles of the head and neck, vertebral column, trunk, and pelvic floor
Muscles of the Head and Neck
Muscles of the Spine
The Axial Muscles of the Trunk
Muscles of the Pelvic Floor
7-11 Appendicular muscles are muscles of the shoulders, upper limbs, pelvic girdle, and lower limbs
Muscles of the Shoulders and Upper Limbs
Muscles of the Pelvis and Lower Limbs
7-12 The size and power of muscle tissue decrease with advancing age
7-13 Exercise produces responses in multiple body systems
SPOTLIGHTS
Events at the Neuromuscular Junction
The Contraction Cycle
CLINICAL NOTES
Interference at the NMJ and Muscular Paralysis
Rigor Mortis
Tetanus
Hernias
Intramuscular Injections
Chapter Review
8 The Nervous System
An Introduction to the Nervous System
8-1 The nervous system has anatomical and functional divisions
8-2 Neurons are specialized for intercellular communication and are supported by cells called neuroglia
Neurons
Neuroglia
Organization of Neurons in the Nervous System
8-3 In neurons, a change in the plasma membrane's electrical potential may result in an action potential (nerve impulse)
The Membrane Potential
Propagation of an Action Potential
8-4 At synapses, communication takes place among neurons or between neurons and other cells
Structure of a Synapse
Synaptic Function and Neurotransmitters
Neuronal Pools
8-5 The brain and spinal cord are surrounded by three layers of membranes called the meninges
The Dura Mater
The Arachnoid
The Pia Mater
8-6 The spinal cord contains gray matter surrounded by white matter and connects to 31 pairs of spinal nerves
Gross Anatomy
Sectional Anatomy
8-7 The brain has several principal structures, each with specific functions
The Major Regions of the Brain
The Ventricles of the Brain
The Cerebrum
The Diencephalon
The Midbrain
The Pons
The Cerebellum
The Medulla Oblongata
8-8 The PNS connects the CNS with the body's external and internal environments
The Cranial Nerves
The Spinal Nerves
Nerve Plexuses
8-9 Reflexes are rapid, automatic responses to stimuli
Simple Reflexes
Complex Reflexes
Integration and Control of Spinal Reflexes
8-10 Separate pathways carry sensory information and motor commands
Sensory Pathways
Motor Pathways
8-11 The autonomic nervous system, composed of the sympathetic and parasympathetic divisions, is involved in the unconscious regulation of body functions
The Sympathetic Division
The Parasympathetic Division
Relationships between the Sympathetic and Parasympathetic Divisions
8-12 Aging produces various structural and functional changes in the nervous system
8-13 The nervous system is closely integrated with other body systems
SPOTLIGHTS
The Generation of an Action Potential
Propagation of an Action Potential
CLINICAL NOTES
Demyelination Disorders
Epidural and Subdural Hemorrhages
Spinal Cord Injuries
Aphasia and Dyslexia
Seizures
Cerebral Palsy
Alzheimer's Disease
Chapter Review
9 The General and Special Senses
An Introduction to General and Special Senses
9-1 Sensory receptors connect our internal and external environments with the nervous system
9-2 General sensory receptors are classified by the type of stimulus that excites them
Pain
Temperature
Touch, Pressure, and Position
Chemical Detection
9-3 Olfaction, the sense of smell, involves olfactory receptors responding to chemical stimuli
The Olfactory Pathways
9-4 Gustation, the sense of taste, involves taste receptors responding to chemical stimuli
The Taste Pathways
9-5 Internal eye structures contribute to vision, while accessory eye structures provide protection
The Accessory Structures of the Eye
The Eye
9-6 Photoreceptors respond to light and change it into electrical signals essential to visual physiology
Rods and Cones
Photoreceptor Structure
Photoreception
The Visual Pathways
9-7 Equilibrium sensations originate within the internal ear, while hearing involves the detection and interpretation of sound waves
Anatomy of the Ear
Equilibrium
Hearing
9-8 Aging is accompanied by a noticeable decline in the special senses
Smell and Aging
Taste and Aging
Vision and Aging
Equilibrium and Aging
Hearing and Aging
SPOTLIGHT
Refractive Problems
CLINICAL NOTES
Cataracts
Visual Acuity
Night Blindness
Hearing Deficits
Chapter Review
10 The Endocrine System
An Introduction to the Endocrine System
10-1 Homeostasis is preserved through intercellular communication
10-2 The endocrine system regulates physiological processes through the binding of hormones to receptors
The Structure of Hormones
Hormone Action
The Secretion and Distribution of Hormones
The Control of Endocrine Activity
10-3 The bilobed pituitary gland is an endocrine organ that releases nine peptide hormones
The Anterior Lobe of the Pituitary Gland
The Posterior Lobe of the Pituitary Gland
10-4 The thyroid gland synthesizes thyroid hormones that affect the rate of metabolism
Thyroid Follicles and Thyroid Hormones
The C Cells of the Thyroid Gland and Calcitonin
10-5 The four parathyroid glands, embedded in the posterior surfaces of the thyroid gland, secrete parathyroid hormone to elevate blood calcium levels
10-6 The adrenal glands, consisting of a cortex and a medulla, cap each kidney and secrete several hormones
The Adrenal Cortex
The Adrenal Medulla
10-7 The pineal gland, attached to the third ventricle, secretes melatonin
10-8 The endocrine pancreas produces insulin and glucagon, hormones that regulate blood glucose levels
Diabetes Mellitus
10-9 Many organs have secondary endocrine functions
The Intestines
The Kidneys
The Heart
The Thymus
The Gonads
Adipose Tissue
10-10 Hormones interact to produce coordinated physiological responses
Hormones and Growth
Hormones and Stress
Hormones and Behavior
Hormones and Aging
10-11 Extensive integration occurs between the endocrine system and other body systems
SPOTLIGHT
The General Adaptation Syndrome
CLINICAL NOTES
Diabetes Insipidus
Diabetes Mellitus
Hormones and Athletic Performance
Endocrine Disorders
Chapter Review
11 The Cardiovascular System: Blood
An Introduction to the Cardiovascular System
11-1 Blood has several important functions and unique physical characteristics
Composition of Blood
Blood Collection and Analysis
11-2 Plasma, the fluid portion of blood, contains significant quantities of plasma proteins
Plasma Proteins
11-3 Red blood cells, formed by erythropoiesis, contain hemoglobin that can be recycled
Abundance of Red Blood Cells
Structure of RBCs
Hemoglobin Structure and Function
RBC Life Span and Circulation
RBC Formation
11-4 The ABO blood types and Rh system are based on antigen–antibody responses
Cross-Reactions in Transfusions
Testing for Blood Compatibility
11-5 The various types of white blood cells contribute to the body's defenses
WBC Circulation and Movement
Types of WBCs
The Differential Count and Changes in WBC Abundance
WBC Formation
11-6 Platelets, disc-shaped structures formed from megakaryocytes, function in the clotting process
11-7 Hemostasis involves vascular spasm, platelet plug formation, and blood coagulation
Phases of Hemostasis
The Clotting Process
Clot Retraction and Removal
SPOTLIGHT
The Composition of Whole Blood
CLINICAL NOTES
Abnormal Hemoglobin
Hemolytic Disease of the Newborn
Abnormal Hemostasis
Chapter Review
12 The Cardiovascular System: The Heart
The Heart's Role in the Cardiovascular System
12-1 The heart is a four-chambered organ, supplied by coronary circulation, that pumps oxygen-poor blood to the lungs and oxygen-rich blood to the rest of the body
The Surface Anatomy of the Heart
The Heart Wall
Internal Anatomy and Organization
12-2 Contractile cells and the conducting system produce each heartbeat, and an electrocardiogram records the associated electrical events
Contractile Cells
The Conducting System
The Electrocardiogram
12-3 Events during a complete heartbeat make up a cardiac cycle
Phases of the Cardiac Cycle
Heart Sounds
12-4 Heart dynamics examines the factors that affect cardiac output
Blood Volume Reflexes
Autonomic Innervation
Hormones
SPOTLIGHT
The Heart: Internal Anatomy and Blood Flow
CLINICAL NOTES
Heart Valve Disorders
Abnormal Conditions Affecting Cardiac Output
Chapter Review
13 The Cardiovascular System: Blood Vessels and Circulation
An Introduction to Blood Vessels and Circulation
13-1 Arteries, arterioles, capillaries, venules, and veins differ in size, structure, and function
The Structure of Vessel Walls
Arteries
Capillaries
Veins
13-2 Pressure and resistance determine blood flow and affect rates of capillary exchange
Factors Affecting Blood Flow
Cardiovascular Pressures within the Systemic Circuit
13-3 Cardiovascular regulation involves autoregulation, neural processes, and endocrine responses
Autoregulation of Blood Flow within Tissues
Neural Control of Blood Pressure and Blood Flow
Hormones and Cardiovascular Regulation
13-4 The cardiovascular system adapts to physiological stress
Exercise and the Cardiovascular System
The Cardiovascular Response to Hemorrhage
13-5 The pulmonary and systemic circuits of the cardiovascular system exhibit three general functional patterns
13-6 In the pulmonary circuit, deoxygenated blood enters the lungs in arteries, and oxygenated blood leaves the lungs in veins
13-7 The systemic circuit carries oxygenated blood from the left ventricle to tissues other than the lungs' exchange surfaces, and returns deoxygenated blood to the right atrium
Systemic Arteries
Systemic Veins
13-8 Modifications of fetal and maternal cardiovascular systems promote the exchange of materials until birth
Placental Blood Supply
Fetal Circulation in the Heart and Great Vessels
Circulatory Changes at Birth
13-9 Aging affects the blood, heart, and blood vessels
13-10 The cardiovascular system is both structurally and functionally linked to all other systems
SPOTLIGHT
Major Vessels of the Systemic Circuit
CLINICAL NOTES
Arteriosclerosis
Capillary Dynamics and Blood Volume and Pressure
Checking the Pulse and Blood Pressure
Exercise, Cardiovascular Fitness, and Health
Shock
Chapter Review
14 The Lymphatic System and Immunity
An Introduction to the Lymphatic System and Immunity
14-1 Anatomical barriers and defense processes make up nonspecific defense, and lymphocytes provide specific defense
14-2 Lymphatic vessels, lymphocytes, lymphoid tissues, and lymphoid organs function in body defenses
Functions of the Lymphatic System
Lymphatic Vessels
Lymphocytes
Lymphoid Tissues
Lymphoid Organs
14-3 Innate (nonspecific) defenses respond in a characteristic way regardless of the potential threat
Physical Barriers
Phagocytes
Immune Surveillance
Interferons
The Complement System
Inflammation
Fever
14-4 Adaptive (specific) defenses respond to specific threats and are either cell mediated or antibody mediated
Forms of Immunity
An Overview of Adaptive Immunity
14-5 T cells play a role in starting and controlling adaptive immunity
Antigen Presentation
T Cell Activation
14-6 B cells respond to antigens by producing specific antibodies
B Cell Sensitization and Activation
Antibody Structure
Antibody Function
Primary and Secondary Responses to Antigen Exposure
Summary of the Immune Response
Hormones of the Immune System
14-7 Abnormal immune responses result in immune disorders
Autoimmune Disorders
Immunodeficiency Diseases
Allergies
14-8 The immune response diminishes as we age
14-9 For all body systems, the lymphatic system provides defenses against infection and returns tissue fluid to the circulation
SPOTLIGHT
Origin and Distribution of Lymphocytes
CLINICAL NOTES
"Swollen Glands"
Injury to the Spleen
AIDS
Stress and the Immune Response
Manipulating the Immune Response
Chapter Review
15 The Respiratory System
An Introduction to the Respiratory System
15-1 The respiratory system, composed of air-conducting and respiratory portions, has several basic functions
Functions of the Respiratory System
Structures of the Respiratory System
15-2 The nose, pharynx, larynx, trachea, bronchi, and larger bronchioles conduct air into the lungs
The Nose
The Pharynx
The Larynx
The Trachea
The Bronchi
15-3 The smallest bronchioles and the alveoli within the lungs make up the respiratory portion of the respiratory tract
The Bronchioles
The Blood Air Barrier
The Lungs
The Pleural Cavities
15-4 External respiration and internal respiration allow gas exchange within the body
15-5 Pulmonary ventilation—the exchange of air between the atmosphere and the lungs—involves pressure changes and muscle movement
Pressure and Airflow to the Lungs
Compliance
Modes of Breathing
Lung Volumes and Capacities
15-6 Gas exchange depends on the partial pressures of gases and the diffusion of molecules
Mixed Gases and Partial Pressures
Partial Pressures in the Pulmonary and Systemic Circuits
15-7 In gas transport, most oxygen is transported bound to hemoglobin, whereas carbon dioxide is transported in three ways
Oxygen Transport
Carbon Dioxide Transport
15-8 Neurons in the medulla oblongata and pons, along with respiratory reflexes, control respiration
The Local Control of Respiration
Control by the Respiratory Centers of the Brain
The Reflex Control of Respiration
Control by Higher Centers
Respiratory Changes at Birth
15-9 Respiratory performance declines with age
15-10 The respiratory system provides oxygen to, and removes carbon dioxide from, other organ
systems
SPOTLIGHTS
Pulmonary Ventilation
The Control of Respiration
CLINICAL NOTES
Cystic Fibrosis
Tracheal Blockage
Pneumonia
Tuberculosis
Decompression Sickness
Carbon Monoxide Poisoning
Emphysema and Lung Cancer
Chapter Review
16 The Digestive System
An Introduction to the Digestive System
16-1 The digestive system—the digestive tract and accessory organs—performs various food-processing functions
Functions of the Digestive System
Histological Organization of the Digestive Tract
The Movement of Digestive Materials
16-2 The oral cavity contains the tongue, salivary glands, and teeth, each with specific functions
The Tongue
Salivary Glands
Teeth
16-3 The pharynx is a passageway between the oral cavity and the esophagus
The Pharynx
The Esophagus
Swallowing
16-4 The J-shaped stomach receives food from the esophagus and aids in chemical and mechanical digestion
The Gastric Wall
The Regulation of Gastric Activity
Digestion in the Stomach
16-5 The small intestine chemically digests and absorbs nutrients
The Intestinal Wall
Intestinal Movements
Intestinal Secretions
Intestinal Hormones
Digestion in the Small Intestine
16-6 The pancreas, liver, and gallbladder are accessory organs that assist with chemical digestion in the small intestine
The Pancreas
The Liver
The Gallbladder
16-7 The large intestine is divided into three parts with regional specialization
The Cecum
The Colon
The Rectum
The Functions of the Large Intestine
16-8 Chemical digestion is the alteration of food that allows the absorption and use of nutrients
The Processing and Absorption of Nutrients
Water and Electrolyte Absorption
Absorption of Vitamins
16-9 Many age-related changes affect digestion and absorption
16-10 The digestive system is extensively integrated with other body systems
SPOTLIGHTS
Regulation of Gastric Activity
Chemical Events in Digestion
CLINICAL NOTES
Gastritis and Peptic Ulcers
Stomach Cancer
Vomiting
Pancreatitis
Liver Disease
Colorectal Cancer
Diverticulosis
Diarrhea and Constipation
Lactose Intolerance
Chapter Review
17 Metabolism and Energetics
An Introduction to Nutrition and Metabolism
17-1 Metabolism refers to all the chemical reactions in the body, and energetics refers to the flow and transformation of energy
17-2 Carbohydrate metabolism involves glycolysis, ATP production, and gluconeogenesis
Glycolysis
Energy Production Within Mitochondria
Energy Yield of Glycolysis and Cellular Respiration
Gluconeogenesis (Glucose Synthesis)
Alternate Catabolic Pathways
17-3 Lipid metabolism involves lipolysis, beta-oxidation, and the transport and distribution of lipids as lipoproteins and free fatty acids
Lipid Catabolism
Lipids and Energy Production
Lipid Synthesis
Lipid Transport and Distribution
17-4 Protein catabolism involves transamination and deamination, and protein synthesis involves amination and transamination
Amino Acid Catabolism
Amino Acids and Protein Synthesis
17-5 Nucleic acid catabolism involves RNA, but not DNA
RNA Catabolism
Nucleic Acid Synthesis
17-6 Adequate nutrition is necessary to prevent deficiency disorders and maintain homeostasis
Food Groups and a Balanced Diet
Minerals, Vitamins, and Water
Diet and Disease
17-7 Metabolic rate is the average caloric expenditure, and thermoregulation involves balancing heat-producing and heat-losing processes
The Energy Content of Food
Energy Expenditure: Metabolic Rate
Thermoregulation
17-8 Caloric needs decline with advancing age
SPOTLIGHT
Electron Transport Chain and ATP Formation
CLINICAL NOTES
Carbohydrate Loading
Dietary Fats and Cholesterol
Ketoacidosis
Chapter Review
18 The Urinary System
An Introduction to the Urinary System
18-1 The urinary system—made up of the kidneys, ureters, urinary bladder, and urethra—has three major functions
18-2 The kidneys are highly vascular organs containing functional units called nephrons, which perform filtration, reabsorption, and secretion
Superficial and Sectional Anatomy of the Kidneys
The Blood Supply to the Kidneys
The Nephron
18-3 Different portions of the nephron form urine by filtration, reabsorption, and secretion
Nephron Processes
Filtration at the Glomerulus
Reabsorption and Secretion along the Renal Tubule
Normal Urine
18-4 Normal kidney function depends on a stable GFR
The Local Regulation of Kidney Function
The Hormonal Control of Kidney Function
18-5 Urine is transported by the ureters, stored in the bladder, and eliminated through the urethra, aided by urinary reflexes
The Ureters
The Urinary Bladder
The Urethra
The Control of Urination
18-6 Fluid balance, electrolyte balance, and acid-base balance are interrelated and essential to homeostasis
The ECF and the ICF
18-7 Blood pressure and osmosis are involved in maintaining fluid and electrolyte balance
Fluid Balance
Electrolyte Balance
18-8 In acid-base balance, regulation of hydrogen ions in body fluids involves buffer systems and compensation by respiratory and renal processes
Acids in the Body
Buffers and Buffer Systems
Maintaining Acid-Base Balance
Acid-Base Disorders
18-9 Age-related changes affect kidney function and the control of urination
18-10 The urinary system is one of several body systems involved in waste excretion
SPOTLIGHT
A Summary of Kidney Function
CLINICAL NOTES
Kidney Failure
Urinary Tract Infections
Incontinence
Disturbances of Acid-Base Balance
Chapter Review
19 The Reproductive System
An Introduction to the Reproductive System
19-1 Basic reproductive system structures are gonads, ducts, accessory glands and organs, and external genitalia
19-2 Sperm formation (spermatogenesis) occurs in the testes, and hormones from the hypothalamus, pituitary gland, and testes control male reproductive functions
The Testes
Spermatogenesis
The Male Reproductive Tract
The Accessory Glands
The External Genitalia
Hormones and Male Reproductive Function
19-3 Ovum production (oogenesis) occurs in the ovaries, and hormones from the pituitary gland and ovaries control female reproductive functions
The Ovaries
The Uterine Tubes
The Uterus
The Vagina
The External Genitalia
The Mammary Glands
Hormones and the Female Reproductive Cycle
19-4 The autonomic nervous system influences male and female sexual function
Male Sexual Function
Female Sexual Function
19-5 With age, decreasing levels of reproductive hormones cause functional changes
Menopause
The Male Climacteric
19-6 The reproductive system secretes hormones affecting growth and metabolism of all body systems
SPOTLIGHTS
Regulation of Male Reproduction
Regulation of Female Reproduction
CLINICAL NOTES
Cryptorchidism
Prostatitis
Pelvic Inflammatory Disease (PID)
Amenorrhea
Breast Cancer
Infertility
Sexually Transmitted Diseases
Birth Control Strategies
Chapter Review
20 Development and Inheritance
An Introduction to Development and Inheritance
20-1 Development is a continuous process that occurs from fertilization to maturity
20-2 Fertilization—the fusion of a secondary oocyte and a sperm—forms a zygote
An Overview of Fertilization
Ovulation and Oocyte Activation
20-3 Gestation consists of three stages of prenatal development: the first, second, and third trimesters
20-4 Critical events of the first trimester are cleavage, implantation, placentation, and embryogenesis
Cleavage and Blastocyst Formation
Implantation
Placentation
Embryogenesis
20-5 During the second and third trimesters, maternal organ systems support the developing fetus, and the uterus undergoes structural and functional changes
The Effects of Pregnancy on Maternal Systems
Structural and Functional Changes in the Uterus
20-6 Labor consists of the dilation, expulsion, and placental stages
The Stages of Labor
Premature Labor
Multiple Births
20-7 Postnatal stages are the neonatal period, infancy, childhood, adolescence, and maturity, followed by senescence
The Neonatal Period, Infancy, and Childhood
Adolescence and Maturity
20-8 Genes and chromosomes determine patterns of inheritance
Patterns of Inheritance
The Human Genome
SPOTLIGHT
Extra-Embryonic Membranes and Placenta Formation
CLINICAL NOTES
Abortion
Chromosomal Abnormalities and Genetic Analysis
Chapter Review
Answers Answers to Checkpoints and Review Questions
Appendix Normal Physiological Values
Glossary/Index
A
B
C
D
E
F
G
H
I
J
K
L
M
N
O
P
Q
R
S
T
U
V
W
X
Y
Z
Credits
