This second edition is a one-source guide to current information about red blood cell physiology and the action of native and recombinant human erythropoietic factors. Topics in the fields of erythropoiesis, recombinant protein discovery and production, and treatment of patients with anemia due to renal failure, cancer, or chronic diseases are covered. The newest theories in erythropoiesis (receptors, signaling), manufacturing, new formulations, and clinical research are discussed.
This book is of interest to researchers and clinical investigators in academia and biotechnology and pharmaceutical companies, to clinical research associates, clinical monitors, and physician investigators.
Author(s): Steven G. Elliott, MaryAnn Foote, Graham Molineux
Series: Milestones in Drug Therapy
Edition: 2nd, revised and extended ed.
Publisher: Birkhäuser Basel
Year: 2009
Language: English
Pages: 326
Contents......Page 6
List of contributors......Page 8
Preface to the first edition......Page 10
Preface to the second edition......Page 14
Abbreviations......Page 16
Background......Page 20
Erythropoiesis: an overview......Page 22
Regulation of endogenous erythropoietin production......Page 38
Biology of erythropoietin......Page 60
Erythropoiesis – genetic abnormalities......Page 80
Erythropoiesis-stimulating agents......Page 94
Studies of erythropoiesis and the discovery and cloning of recombinant human erythropoietin......Page 96
Commercial production of recombinant erythropoietins......Page 106
Biosimilar epoetins......Page 124
New molecules and formulations......Page 134
Erythropoietin receptor......Page 160
Structural basis for the signal transduction of erythropoietin......Page 162
Intracellular signaling by the erythropoietin receptor......Page 174
Mechanism of erythropoietin receptor activation......Page 194
Clinical utility......Page 216
Pharmacokinetics of erythropoiesis-stimulating agents......Page 218
Use of erythropoietic stimulating agents in the setting of renal disease......Page 244
Abuse of recombinant erythropoietins and blood products by athletes......Page 268
Role and regulation of iron metabolism in erythropoiesis and disease......Page 298
Nonhematopoietic effects of erythropoiesis-stimulating agents......Page 318
C......Page 338
E......Page 339
F......Page 340
H......Page 341
N......Page 342
R......Page 343
T......Page 344
Z......Page 345
