Epilepsy has afflicted humankind throughout recorded history; yet, it is only in the last half-century, that significant progress has been made in our basic understanding of the epileptic brain. Pivotal advances in drug development and surgical techniques, as well as the emergence of innovative approaches such as electrical stimulation of the nervous system, have led to a substantial reduction in the morbidity and mortality of patients with epilepsy. At the same time, remarkable developments in neuroscience have enhanced our understanding of brain structure and function.
Epilepsy: Mechanisms, Models, and Translational Perspectives incorporates new translational advances that bring epilepsy therapies from the laboratory bench to the bedside and back again. It brings together the work of more than 70 of the field’s most respected and cutting-edge researchers and clinicians. In 24 chapters, this extraordinarily comprehensive and current work:
Offers an overview of the basic anatomic and functional substrates of seizure genesis and considers novel pathogenic concepts that have both emerged and been validated experimentally
— Examines antiepileptic drug therapy, including the latest on molecular targets
— Looks at the state of surgical treatments for epilepsy and discusses advances in the fields of structural and functional neuroimaging
— Reviews the variety of nontraditional therapeutic options, such as the ketogenic diet, the vagus nerve stimulator, immunomodulators, neurosteroids, herbs, and botanicals
— Investigates neuroendocrine, hormonal, and biobehavioral factors that influence seizure susceptibility—information that can be incorporated into the design of treatment algorithms on an individualized basis
— Provides a glimpse of what future epilepsy therapies might look like, from novel mechanisms of drug delivery to gene and stem-cell therapies for epilepsy to seizure detection methods, to the ultimate goal of disease prevention.
The idea for this book was inspired by the editors’ collective desire to promote bridging of the so-called translational divide—that is, covering innovative treatment strategies based on scientific principles that have yet to be tested rigorously in the clinical setting, but yet may provide practitioners with new and promising approaches toward epilepsy therapeutics.
Author(s): Jong Rho, Raman Sankar, Carl E. Stafstrom
Series: Neurological Disease and Therapy
Publisher: CRC Press
Year: 2010
Language: English
Pages: xxii, 646
City: Boca Raton, FL
Tags: Медицинские дисциплины;Неврология и нейрохирургия;
Content: Pathophysiological mechanisms of seizures and epilepsy: a primer / Carl E. Stafstrom --
Blood-brain barrier, blood flow, neoplasms, and epilepsy: the role of astrocytes / Luca Cucullo ... [et al.] --
Metabolic regulation of seizures and epileptogenesis / Manisha Patel --
Brain inflammation and epilepsy / Teresa Ravizza ... [et al.] --
Drug resistance in epilepsy and status epilepticus / Jaideep Kapur and Edward H. Bertram --
Epilepsy with complex genetics: looking beyond the channelopathies / Asuri N. Prasad and Chitra Prasad --
Pathophysiology of developmental epilepsies / Judith L.Z. Weisenberg and Michael Wong --
Mechanisms of antiepileptic drug action / Timothy A. Simeone --
Epilepsy and disease modification: animal models for novel drug discovery / H. Steve White --
Pharmacogenetics of AED development / Russell J. Buono ... [et al.] --
Neuroprotective strategies using antiepileptic drugs / Patrick G. Sullivan and Ryan D. Readnower --
Posttraumatic seizures and epileptogenesis: good and bad plasticity / Christopher C. Giza --
Possible roles of nonsynaptic mechanisms in synchronization of epileptic seizures: potential antiepileptic targets? / F. Edward Dudek, Li-Rong Shao, and John E. Rash --
A mechanistic approach to antiepileptic drug interactions / Gail D. Anderson --
Advances in structural and functional neuroimaging: how are these guiding epilepsy surgery? / Hyunmi Kim, A. LeBron Paige, and Robert C. Knowlton --
Magnetoencephalography in clinical epilepsy: a translational viewpoint / Jerry J. Shih and Michael P. Weisend --
What have we learned from resective surgery in pediatric patients with cortical dysplasia? / Carlos Cepeda and Gary W. Mathern --
Nonsurgical ablation for epilepsy / Erich O. Richter ... [et al.] --
Deep brain stimulation for epilepsy / Francisco Velasco ... [et al.] --
Optical imaging techniques in pediatric neocortical epilepsy / Daryl W. Hochman and Michael M. Haglund --
High-frequency oscillations in epileptic brain / S. Matt Stead, Mark Bower, and Greg Worrell --
Special treatments in epilepsy / Kevin Chapman and James W. Wheless --
Herbs and botanicals / Steven C. Schachter --
The ketogenic diet: scientific principles underlying its use / Kristopher J. Bough and Carl E. Stafstrom --
Vagus nerve stimulation / Matthew M. Troester and Dean K. Naritoku --
Antiinflammatory treatments for seizure syndromes and epilepsy / Stéphane Auvin and Raman Sankar --
Impact of neuroendocrine factors on seizure genesis and treatment / Pavel Klein and Jaromir Janousek --
Neurosteroid replacement therapy for catamenial epilepsy / Doodipala S. Reddy and Michael A. Rogawski --
Chronobiology and sleep: implications for seizure propensity / Mark Quigg --
Pediatric epilepsy: a developmental neuropsychiatric disorder / Rochelle Caplan --
Novel mechanisms of drug delivery / Vijay Ivaturi and James Cloyd --
Early seizure detection: considerations and applications / Christophe C. Jouny, Piotr J. Franaszczuk, and Gregory K. Bergey --
Gene and stem cell therapies for treating epilepsy / Janice R. Naegele and Xu Maisano --
Arresting epileptogenesis: the current challenge / Philip A. Schwartzkroin.
