Epigenetics of Aging

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Revealing the molecular basis of aging has been one of the most challenging aspects of medical science, and now the epigenetics of aging is in a Renaissance phase. This seminal work covers the fascinating role of epigenetics in aging, ranging from basic epigenetic processes of aging to epigenetic drugs that may intervene in allow aging and age-related diseases.

Epigenetics of Aging presents in-depth analyses of DNA methylation, histone modifications, RNA alterations, and chromosomal defects that impact the aging process. It also includes detailed essays describing the impact of epigenetics on aging, the epigenetics of age-related diseases, and future directions and perspectives on the epigenetics of aging.

With chapters authored by leading researchers in the field, this seminal book on the epigenetics of aging:

-Ranges from basic science to clinical practice

-Describes the importance of epigenetics in numerous diseases of aging such as cancer, Alzheimer’s disease, immune defects, and osteoporosis

-Includes the role of epigenetics in premature aging diseases such as progeria

-Highlights emerging aspects of epigenetics in aging, such as polycomb group genes and noncoding RNAs

-Covers sirtuins, chromatin alterations, and the role of epigenetic drift in aging

-Describes the impact of the environment and diet in modulating epigenetic processes during aging

Epigenetics of Aging is the first book in this exponentially expanding field, and will be an indispensable source of information for those with interests in epigenetics and/or aging. This authoritative core textbook for advanced students or medical scientists and practitioners details the fascinating and revolutionary field of the epigenetics of aging and covers the most recent advances that impact the longevity of living organisms.

Author(s): Trygve O. Tollefsbol (auth.), Trygve O. Tollefsbol (eds.)
Edition: 1
Publisher: Springer-Verlag New York
Year: 2010

Language: English
Pages: 469
Tags: Human Genetics; Cancer Research; Pharmacology/Toxicology

Front Matter....Pages i-xiv
Front Matter....Pages 1-1
Epigenetics and the Aging Process....Pages 1-8
Age-Related Genomic Hypomethylation....Pages 11-27
Sirtuins and Aging....Pages 51-75
Chromatin in Senescent Cells: A Conduit for the Anti-Aging Effects of Wnt Signaling?....Pages 77-105
Front Matter....Pages 9-9
Gene-Specific Hypermethylation in Aging....Pages 29-39
Aging and Non-sirtuin Histone Modifications....Pages 41-50
S -Adenosylmethionine: Simple Agent of Methylation and Secret to Aging and Metabolism?....Pages 107-131
Front Matter....Pages 133-133
Polycomb Group of Genes and the Epigenetics of Aging....Pages 135-150
Chromosomal Position Effect and Aging....Pages 151-175
Noncoding RNA for Presymptomatic Diagnosis of Age-Dependent Disease....Pages 177-188
Contributions of Tumor Suppressors to the Epigenetic Regulation of Aging Cells....Pages 227-255
Front Matter....Pages 189-189
Telomerase Control by Epigenetic Processes in Cellular Senescence....Pages 191-204
Telomeres, Epigenetics, and Aging....Pages 205-225
Epigenetic Drift and Aging....Pages 257-273
Role of Epigenetics in Age-Related Long-Term Memory Loss....Pages 275-281
DNA Methylation, Age-Related Immune Defects, and Autoimmunity....Pages 327-344
Epigenetic Silencing of Progeroid Syndromes....Pages 345-369
DNA Methylation and Osteoarthritis....Pages 371-391
Front Matter....Pages 283-283
The Epigenetics of Age-Related Cancers....Pages 285-313
DNA Methylation and Alzheimer’s Disease....Pages 315-326
Front Matter....Pages 393-393
Histone-Modifying Drugs in Aging....Pages 395-406
Dietary Effect on Epigenetics During the Aging Process....Pages 407-416
Front Matter....Pages 283-283
Environmental Effects on Age-Associated Epigenetics....Pages 417-429
Front Matter....Pages 431-431
Future Directions in Research on the Epigenetics of Aging....Pages 433-446
Perspectives in Aging and Epigenetics....Pages 447-455
Epigenetic Silencing of Progeroid Syndromes....Pages E1-E1
Back Matter....Pages 457-469