Garland Science, 2014. - 319 p. - The concept of epigenetics has been known about since the 1940s, but it is only in the last 10 years that research has shown just how wide ranging its effects are. It is now a very widely-used term, but there is still a lot of confusion surrounding what it actually is and does.
Epigenetics is a new textbook that brings together the structure and machinery of epigenetic modification, how epigenetic modification controls cellular functions, and the evidence for the relationship between epigenetics and disease. It is a valuable source of information about all aspects of the subject for undergraduate students, graduate students, and professionals.Contents
Introduction to the Study of Epigenetics
The Basis of the Transcription Process
DNA Packaging and Chromatin Architecture
Modifying the Structure of Chromatin
DNA Methylation
Post-Translational Modification of Histones
Histone Modification Machinery
Locus-Specific Control of Histone-Modifying Enzyme Action
Epigenetic Control of Cell-Specific Gene Expression
Epigenetic Control of the Mitotic Cell Cycle
The Epigenetic Basis of Gene Imprinting
Epigenetic Control of Cellular Differentiation
Reversibility of Epigenetic Modification Patterns
Epigenetic Predisposition to Disease and Imprinting-Based Disorders
Epigenetics of Memory, Neurodegeneration, and Mental Health
Epigenetics of Cancer
