Organic synthesis with enzymes - the only way
This comprehensive set gives reliable answers to all questions on enzyme catalysis - from searching for suitable catalytic systems via choosing the optimal reaction conditions to implementing modern synthesis strategies. The long-awaited new edition has been greatly expanded to include new topics and to reflect the latest research, yet retains the clear and practice-oriented presentation found in the first edition. More than a mere data collection, the three volumes provide synthetic chemists with easy access to all the first-hand information necessary for successfully using enzymes:
- the latest synthesis methods
- example applications arranged according to reaction type
- a table of all the important, commercially available enzymes
- comprehensive registers for targeted searching according to enzyme, compound, or reaction
- current references to the literature
In short, an indispensable reference that should be on the shelf of every modern synthesis laboratory. Content:
Chapter 1 Introduction (pages 1–39): Maria?Regina Kula
Chapter 2 Production and Isolation of Enzymes (pages 41–66): Yoshihiko Hirose
Chapter 3 Rational Design of Functional Proteins (pages 67–93): Tadayuki Imanaka and Haruyuki Atomi
Chapter 4 Enzyme Engineering by Directed Evolution (pages 95–138): Oliver May, Christopher A. Voigt and Frances H. Arnold
Chapter 5 Enzyme Bioinformatics (pages 139–162): Kay Hofmann
Chapter 6 Immobilization of Enzymes (pages 163–184): James Lalonde and Alexey Margolin
Chapter 7 Reaction Engineering for Enzyme?Catalyzed Biotransformations (pages 185–257): Manfred Biselli, Udo Kragl and Christian Wandrey
Chapter 8 Enzymic Conversions in Organic and Other Low?Water Media (pages 259–285): Peter Halling
Chapter 9 Enzymatic Kinetic Resolution (pages 287–312): Jonathan M. J. Williams, Rebecca J. Parker and Claudia Neri
Chapter 10 Enzymes from Extreme Thermophilic and Hyperthermophilic Archaea and Bacteria (pages 313–334): Costanzo Bertoldo and Garabed Antranikian
Chapter 11 Hydrolysis and Formation of Carboxylid Acid Esters (pages 335–578): Hans Joachim Gais and Fritz Theil
Chapter 11 Hydrolysis of Epoxides (pages 579–608): Kurt Faber and Romano V. A. Orru
Chapter 11 Hydrolysis and Formation of Glycosidic Bonds (pages 609–653): Chi?Huey Wong
Chapter 11 Natural Polysaccharide?Degrading Enzymes (pages 653–685): Constanzo Bertoldo and Garabed Antranikian
Chapter 11 Addition of Water to C=C Bonds (pages 686–697): Marcel Wubbolts
Chapter 12 Hydrolysis of Nitriles (pages 699–715): Birgit Schulze
Chapter 12 Formation and Hydrolysis of Amides (pages 716–740): Birgit Schulze and Erik De Vroom
Chapter 12 Hydrolysis of N?Acylamino Acids (pages 741–761): Andreas S. Bommarius
Chapter 12 Hydrolysis and Formation of Hydantoins (pages 761–799): Markus Pietzsch and Christoph Syldatk
Chapter 12 Hydrolysis and Formation of Peptides (pages 800–865): Hans?Dieter Jakubke
Chapter 12 Addition of Amines to C = C Bonds (pages 866–872): Marcel Wubbolts
Chapter 12 Transaminations (pages 873–893): J. David Rozzell and Andreas S. Bommarius
Chapter 13 Formation and Cleavage of P?O Bonds (pages 895–929): George M. Whitesides
Chapter 14 Formation of C?C Bonds: Sections 14.1 ? 14.6 (pages 931–974): Chi?Huey Wong
Chapter 14 Formation of C?C Bonds: Enzymatic Synthesis of Cyanohydrins (pages 974–989): Martin H. Fechter and Herfried Griengl
Chapter 15 Reduction of Ketones (pages 991–1033): Kaoru Nakamura and Tomoko Matsuda
Chapter 15 Reduction of Various Functionalities (pages 1033–1047): Kaoru Nakamura and Tomoko Matsudo
Chapter 15 Reduction of C=N bonds (pages 1047–1063): Andreas S. Bommarius
Chapter 16 Oxygenation of C?H and C?C Bonds (pages 1065–1108): Sabine Flitsch, Gideon Grogan and D. Ashcroft
Chapter 16 Oxidation of Alcohols (pages 1108–1170): Andreas Schmid, Frank Hollmann and Bruno Buhler
Chapter 16 Oxidation of Phenols (pages 1170–1194): Andreas Schmid, Frank Hollmann and Bruno Buhler
Chapter 16 Oxidation of Aldehydes (pages 1194–1202): Andreas Schmid, Frank Hollmann and Bruno Buhler
Chapter 16 Baeyer?Villiger Oxidations (pages 1202–1245): Sabine Flitsch and Gideon Grogan
Chapter 16 Oxidation of Acids (pages 1245–1250): Andreas Schmid, Frank Hollmann and Bruno Buhler
Chapter 16 Oxidation of C?N Bonds (pages 1250–1261): Andreas Schmid, Frank Hollmann and Bruno Buhler
Chapter 16 Oxidation at Sulfur (pages 1262–1266): Karl?Heinz van Pee
Chapter 16 Halogenation (pages 1267–1280): Karl?Heinz van Pee
Chapter 17 Isomerazation (pages 1281–1332): Nobuyoshi Esaki, T. Kurihara and K. Soda
Chapter 18 Introduction and Removal of Protecting Groups (pages 1333–1417): Dieter Kadereit, Reinhard Reents, Duraiswamy A. Jeyaraj and Herbert Waldmann
Chapter 19 Replacing Chemical Steps by Biotransformations: Industrial Application and Processes Using Biocatalysis (pages 1419–1459): Andreas Liese
Chapter 20 Tabular Survey of Commercially Available Enzymes (pages 1461–1518): Peter Rasor
