Endocrinology of the Breast: Basic and Clinical Aspects

Front Cover
Title Page 1
Title Page 2
Copyright
Contents
Foreword (Angeli, Bradlow, & Dogliotti
I. Hormonal Control of Mammary Development and Growth
Three Stages of Responsiveness to Hormones in the Mammary Cell (Topper et al.)
Estrogens Regulate Production of Specific Growth Factors in Hormone-Dependent Human Breast Cancer (Lippman et al.)
Steroid Hormone Receptor Regulation by Various Hormonal Factors during Mammary Development and Growth in the Normal Mouse (Muldoon)
The Pituitary Gland in Primate Mammary Development: Evidence That Prolactin Is Not Essential (Kleinberg & Newman)
Identification and Characterization of Monoclonal Antibodies to Prolactin Receptors from the Mammary Gland (Kelly, Katoh, & Djiane)
Breast Development in Puberty (Drife)
II. Hormonal Control of Lactation
Advances in Physiology of Human Lactation (Robyn et al.)
Hormones in Milk (Schams & Karg)
Regulatory Sequences Involved in the Hormonal Control of Casein Gene Expression (Rosen)
III. Hormone Metabolism in Mammary Gland
Estrogens and Breast Cancer (Siiteri, Simberg, & Murai)
Uptake and Concentration of Steroid Hormones in Mammary Tissues (Thijssen, van Landeghem, & Poortman)
Androgen and Estrogen Metabolism in Breast Cancer Patients (James et al.)
Enzymatic Control of Estrogen Production in Human Breast Cancer: Relative Significance of Aromatase versus Sulfatase Pathways (Santen et al.)
16α-Hydroxylation of Estradiol: A Possible Risk Marker for Breast Cancer (Bradlow et al.)
Estradiol/Progesterone Interaction in Normal and Pathologic Breast Cells (Mauvais-Jarvis, Kuttenn, & Gompel)
Interaction between Estrogen Receptor and Subcellular Structures of Target Cells: Nuclear Localization of Unoccupied Receptor and Its Modification Induced by Estradiol (Puca)
IV. Hormone Receptors in Mammary Gland and the Mechanism of Hormone Action at the Cellular Level
The 52K Estrogen-Regulated Protein Secreted by Breast Cancer Cells and Its Clinical Potential (Rochefort, Garcia, & Vignon)
The Role of Lysyl, Arginyl, and Sulf hydryl Residues in Estrogen Receptor Activation, 4s to 5s Dimerization, and Conversion of Receptor from a State with Low Affinity into a State with Higher Affinity for Estrogen (Müller & Traish)
Hormone-Responsive Creatine Kinase in Normal and Neoplastic Mammary Glands (Kaye et al.)
V. Hormone-Pathology Relationships of Breast Disease
Early Pathologic Changes in Experimental and Human Breast Cancer: Facts and Comments (Squartini et al.)
Morphologic and Functional Aspects of Apocrine Metaplasia in Dysplastic and Neoplastic Breast Tissue (Bussolati et al.)
Hormonal Correlates of Apocrine
Secretion in the Breast (Miller, Dixon, & Forrest)
The Use of Cultured Human Mammary Epithelial Cells in Defining Malignant Progression (Smith & Hackett)
Interrelationship between Pituitary and Ovarian Hormones in Normal and Neoplastic Growth of Mammary Glands of Mice (Nagasawa et al.)
Steroid Profiles and Optimization of High-Per f or mance Liquid Chromatographic Analytic Procedure (Castagnetta et al.)
VI. Clinical Aspects of Benign Breast Disease
Breast Cyst Fluid Proteins and
Breast Cancer (Zangerle et al.)
Current Status of Hormonal Therapy of Fibrocystic Breast Disease (Dogliotti et al.)
Benign Breast Disease and Cancer Risk: New Perspectives (Mansel et al.)
VII. Breast Cancer Risk and Role of Hormones
Family History and Hormones in Stepwise Mammary Carcinogenesis (Black & Zachrau)
Relation between Risk of Breast Cancer and Biological Availability of Estradiol in the Blood: Prospective Study in Guernsey (Bulbrook et al.)
An Antibody-Toxin Conjugate Directed against a Human Mammary Cancer Antigen (Monaco et al.)
The Endocrinology of the Abnormal Male Breast (Korenman)
VIII. Poster Papers
Mammary Dysplasia in Adolescence: Clinical, Diagnostic, and Histologic Findings (Aragona et al.)
The Risk of Breast Cancer after Estrogen Treatment in Women in the Climacteric: A Prescription-Based Cohort Study (Bergkvist, Adami, & Persson)
Gel Chromatography of Immunoextracted Calcitonin in Human Milk (Bucht, Arver, & Sjöberg)
Evaluation of Postprandial Hyperprolactinemia in Physiological and Nonphysiological Galactorrhea (Maestri et al.)
Inhibition of Lactation by a New Long-Acting as Well as Oral Bromocriptine: Evidence for a Low Threshold of Prolactin for Lactation (Peters et al.)
Mammary Gland Prolactin Receptors in Normal and in Female Rats with Absence of Lactation (IPL Rats) (Guillaumot et al.)
Prolactin Receptors and Lactalbumin Plasma Production in Human Breast Cancer (Peyrat et al.)
Plasma Membrane Properties in Human Breast Tissues and Cell Lines (Losa)
Glucocorticoid Receptors in Neonatal Rat Mammary Gland (Turrel, Propper, & Adessi)
Steroid Receptor Determinations in Malignant Mammary Tumors and in Nonaffected Mammary Glands in the Dog (Rutteman & Misdorp)
Myoepithelial Marker in the Human Breast (Dairkee et al.)
Estrogen-Inducible Gene in Human Breast Cancer (Gairard et al.)
Possible Auto-Stimulation of Human Mammary Carcinoma Growth by Somatomedin (Spencer & Bennington)
A Bombesin-Related Peptide in Experimental Mammary Tumors in Rats (Gaudino, de Bortoli, & Lazarus)
Fibronectin Concentration in Plasma of Patients with Breast Cancer (Guarneri et al.)
Is the Decreased Risk of Breast Cancer due to Early Age at First Baby and Multiparity Mediated by Prolactin? (Wang, Kwa, & Bulbrook)
Influence of Pregnancy on the Time of Presentation of Primary Breast Cancer (Nicholson et al.)
Pituitary-Gonadal Status, and Genetic, Constitutional, and Environmental Factors in Italian Premenopausal Healthy Women with Respect to Breast Cancer Risk: Preliminary Results (Berta et al.)
Mammary Control of Iron Secretion in Milk (Ponzone, Ferrero, & Arosio)
Inhibition of Lactation with Depot-Bromocriptine (Lancranjan, Rolland, & L'Hermite)
Relaxin Induces Proliferation and Differentiation of the Myoepithelial Cells of the Mouse Mammary Gland (Bani et al.)
Detection of Transferrin Receptors in Cultured Breast Cancer Cells (Vandewalle et al.)
Estrogen Stimulation of Growth of Human Breast Cancer Cell Lines (Lykkesfeldt & Briand)
Effect of Estradiol and the Synthetic Progestin Promegestone (R5020) on the Proliferation of Human Mammary Cells in Culture (Malet et al.)
Influence of the Nature of Serum on the Estrogen Sensitivity of the MCF-7 Breast Cancer Cell Line (Devleeschouwer, Olea-Serrano, & Leclercq)
High-Affinity Cytosol Binding Site(s) for Antiestrogen in Cell Lines Devoid of Estrogen Receptor and in Human Breast Cancer Biopsy Specimens (Chouvet & Saez)
Effect of Estradiol on Nonmalignant Human Mammary Cells in Primary Culture (Cavalié et al.)
Effects of Medroxyprogesterone Acetate on Human Breast Cancer Cells in Culture (Braunsberg & Bonney)
Phenotypic Modulation of Sex Steroid Receptors in DMBA-Induced Mammary Carcinoma of the Rat by Estrogens and Tamoxifen (Zanardi et al.)
The Biologically Active Concentrations of Antiestrogens Are Disproportionately Elevated Relative to the Binding Affinity for the Estrogen Receptor (Marth et al.)
Creatine Kinase Activity and Steroid Hormone Receptors in Primary Breast Cancer (Scambia)
Relationship between Receptor Status and Cytosol Levels of E1, E2, E3, and DHAS in Breast Carcinoma (Gion et al.)
Detection of Breast Carcinoma Hormone Dependency by Immunohistochemical-PAP Technique: A Modified Method to Detect Estradiol Binding Sites (Santeusanio, di Tondo, & Pascal)
Plasma Estrone Sulfate and Estrone Sulfatase Activity in Human Breast Carcinoma (Adessi et al.)
Identification of 21-Acyl-[3H]Corticosterone, a Mammary Gland Metabolite, as [3H]Corticosterone 21-Oleate, and Its Significance (Pearlman et al.)
The Effect of Vitamin C on Plasma Levels of Estrogens, Androgens, and Cortisol (Beranek et al.)
Prognostic Value of Deoxyribonucleic Acid (DNA) and Ribonucleic Acid (RNA) Content of Human Breast Carcinomas: Correlation with Clinical and Histologic Features and Hormone Receptors (Lidereau et al.)
Steroid Receptor and Secretion- Associated Peanut Lectin (PNA) Binding in Breast Cancer (Martin et al.)
Estradiol and Progesterone Receptors in the Cytosol and Nuclei of Metastases from Breast Cancer (Concolino et al.)
Molecular Basis for Progestagen Therapy in Mammary Carcinoma (Spona et al.)
The Prognostic and Therapeutic Importance of the Relationship between Sex Chromatin and Hormonal Receptors in Breast Cancer (Zanoio et al.)
Multiple Steroid Receptor Determination in Patients with Breast Cancer (Jakesz et al.)
Estrogen Receptor Variations after Systemic Treatment in Breast Cancer (Toma et al.)
Association of Tumor Differentiation with Hormone Receptors and Obesity in Women with Breast Cancer (Papatestas, Fagerstrom, & Aufses)
Failure of Cytoplasmic Estrogen Receptor Assay as a Prognostic Guide in Primary Breast Cancer (Furnival et al.)
Correlation of Steroid Receptors with Histologic Differentiation in Mammary Carcinoma: A Singapore Experience (Chua et al.)
The Status of Estrogen Receptors in Iranian Pre- and Postmenopausal Breast Cancer Patients (Zia'Ee et al.)
Steroid, Prolactin, and Dopamine Receptors in Normal and Pathologic Breast Tissue (di Carlo et al.)
Natural Growth Rate in 300 Primary Breast Carcinomas and Correlation to Hormone Factors (Fournier et al.)
Benign, Dysplastic, and Preinvasive Lesions Associated with Invasive Breast Carcinoma: Age-Related Frequency (Fessia et al.)
Immunohistochemical Detection of Alpha-Lactalbumin and Gross Cyst Fluid Protein in Human Breast Carcinoma (Spyratos et al.)
The Hormonal Etiology of Breast Disease: A New Approach Using the Determination of Salivary Progesterone (Read et al.)
Abnormal Salivary Steroid Levels in Benign Breast Disease (Gravina et al.)
Plasma Hormones in Premenopausal Women with Benign Breast Disease (Bruning et al.)
Peripheral Levels of Androgens and of Some Steroid-Sensitive Plasma Proteins in Patients with Fibrocystic Breast Disease (Carlström et al.)
Preliminary Reports on Plasma Prolactin and TSH Responses to Domperidone and TRH Administration in Patients Affected by Simple Thyroid Goiter Associated with Benign Breast Disease (Rolla et al.)
Prolactin Dynamics after Acute Stimulation with Thyrotropin- Releasing Hormone and Domperidone in Women with Fibrocystic Disease of the Breast (Dogliotti et al.)
Steroid Sulfates Present in Breast Cyst Fluid (Vanluchene et al.)
Cations and Dehydroisoandrosterone-Sulfate in Human Breast Cyst Fluid (Orlandi et al.)
Carcinoembryonic Antigen (CEA) in Human Breast Cyst Fluid: A Study of 101 Cases (Olivati et al.)
Steroid-Hormone-Binding Proteins in Benign and Malignant Breast Tissue and Their Relevance for Prognosis (Etzrodt et al.)
Endocrine Profile: Its Possible Predictive Significance during Treatment with Medroxyprogesterone Acetate at High Doses in Postmenopausal Patients with Advanced Breast Cancer (Pannuti et al.)
Differential Significance of Prolactin Elevation in Patients with Metastatic Breast Cancer Treated with Medroxyprogesterone Acetate in High Dosage (Blossey et al.)
The Clinical and Hormonal Effects of Bromocriptine in Patients with Fibrocystic Breast Disease (Kösebay, Saner, & Atasü)
The Treatment of Benign Breast Disease: Comparison of Bromocriptine, Norethisterone Acetate, and Placebo (Saccani et al.)
A Double-Blind Trial in the Evaluation of Bromocriptine in the Treatment of Fibrocystic Breast Disease (Parlati et al.)
Relative Efficacy of Bromocriptine and Progesterone per Cutem in Treating Fibrocystic Breast Disease (Raso et al.)
Fibrocystic Disease of the Breast Associated with Pituitary-Ovarian Dysfunction: Results of Treatment with Bromocriptine (Falsetti et al.)
Reduction of Cysts in Fibrocystic Breast Disease during and after Danazol Treatment (Rasmussen, Tobiassen, & Döberl)
Comparison of Tamoxifen and Bromocriptine in Management of Fibrocystic Breast Disease: A Randomized Blind Study (Sandrucci et al.)
Relationship between Age and Dehydroepiandrosterone Sulfate in Breast Secretions (Boccuzzi et al.)
β-HCG in Breast Cyst Fluid (Greenblatt & Mahesh)
Molecular Mechanisms of Tumor Promotion and Multistage Carcinogenesis: Relevance to Breast Cancer (Weinstein)
Index of Contributors