The book focuses on a global problem challenging the health systems. Trypanosoma cruzi infections are transmitted by cone-nosed triatomine bugs, by blood transfusion and congenitally from mothers to their offspring. the American Trypanosomiasis affects 20 million people; among them a significant parcel (< 1/3) will develop Chagas disease in the heart and digestive tract, where the immune system effector cells destroy target host cells. Genotype modifications resulting from transfer of minicircle sequence kDNA from the parasite into the host's genome may explain the autoimmune pathogenesis of the disease. the book discusses various aspects of this disease and should be of interest to readers who wish to keep abreast of the developments in this field.
Author(s): Antonio Teixeira, Marina Vinaud, Ana Maria Castro
Publisher: Bentham Science Publishers
Year: 2011
Language: English
Pages: 191
City: Sharjah
Foreword Pp.i-ii
Wanderley de Souza
Preface Pp.iii-iv
Antonio Teixeira
Contributors Pp.v-vii
Antonio Teixeira, Marina Vinaud and Ana Maria Castro
History of Chagas Disease as a Public Health Problem in Latin America Pp.1-9
João Carlos Pinto Dias and Christopher John Schofield
Endemic Chagas Disease Pp.10-17
Antonio Teixeira, Rubens Nascimento and Nancy R Sturm
Chagas Disease: A Global Health Problem Pp.18-23
Ana Maria Castro, Marina Clare Vinaud and Antonio Teixeira
Triatomine-Vector of Trypanosoma cruzi Infection Pp.24-39
Liléia Diotaiuti
A Review on the Ultrastructure of Trypanosoma cruzi Pp.40-62
Wanderley de Souza, Kildare Miranda, Narcisa Leal Cunha e Silva and Thaïs Souto-Padrón
Trypanosoma cruzi Mitochondrial DNA and the Parasite Lifecycle Pp.63-69
Nancy R. Sturm
Trypanosoma cruzi Nuclear DNA and its Correlation with the Parasite Lifecycle Pp.70-82
David A. Campbell
Host-Parasite Biology of Trypanosoma cruzi Infection Pp.83-93
Conrad L. Epting, Kevin M. Bonney, Cheryl L. Olson and David M. Engman
Acquired Immunity against Trypanosoma cruzi Infection and Vaccine Development Pp.94-103
Maurício Martins Rodrigues, Bruna Cunha de Alencar and José Ronnie Vasconcelos
Clinic Presentation of Chagas Disease Pp.104-109
Antonio R.L. Teixeira
The Pathology of Chagas Disease Pp.110-121
Antonio Teixeira, Fernando Pimentel and Ciro Cordeiro
Lateral Transfer of Minicircle Sequences of kDNA from Trypanosoma cruzi to the Genome of the Vertebrate Host Pp.122-131 (10)
Nadjar Nitz and Antonio Teixeira
The Pathogenesis of Chagas Disease in Mammals and Birds Pp.132-137
Antonio RL Teixeira, Nadjar Nitz, Perla F Araujo and Mariana M Hecht
The Treatment of Chagas Disease Pp.138-144
Liana Lauria-Pires, Ana de Cassia Rosa, Rozeneide Magalhães and Cleudson Nery de Castro
Perspectives in Drug Development for Chagas Disease Therapy Pp.145-155
Izabela M. Dourado Bastos, David Neves, Meire M. Lima and Jaime M. Santana
Environment, Interactions Between Trypanosoma cruzi and its Host, and Health Pp.156-167
Antonio Teixeira, Clever Gomes, Silene Lozzi, Mariana Hecht, Ana Rosa, Pedro Monteiro,, Ana Bussacos, Nadjar Nitz and Concepta McManus
Medical-Social Aspects of Chagas Disease Pp.168-173
Antonio Teixeira, Mariana Hecht and Alessandro Sousa
Index Pp.174-180
Antonio Teixeira, Marina Vinaud and Ana Maria Castro
