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Author(s): Michael Harmata (Eds.)
Series: Strategies and Tactics in Organic Synthesis 6
Publisher: Elsevier Academic Press
Year: 2005

Language: English
Pages: 1-476
City: Amsterdam

Content:
Contributors
Pages xv-xvii

Foreword
Pages xix-xx
Paul A. Wender

Preface
Page xxi
Michael Harmata

Dedication
Page xxiii

Chapter 1 The total synthesis of luzopeptins Original Research Article
Pages 1-37
Marco A. Ciufolini

Chapter 2 Synthesis of geldanamycin using glycolate aldol reactions Original Research Article
Pages 38-70
Merritt B. Andrus, Erik J. Hicken, Erik L. Meredith

Chapter 3 From methylene bridged glycoluril dimers to cucurbit[n]uril analogs with some detours along the way Original Research Article
Pages 71-99
Lyle Isaacs, Jason Lagona

Chapter 4 Application of silicon-assisted intramolecular cross-coupling in total synthesis of (+)-brasilenyne Original Research Article
Pages 100-136
Scott E. Denmark, Shyh-Ming Yang

Chapter 5 Samarium(II) promoted ketyl olefin cyclizations applied to the total syntheses of (−)-steganone and (+)-isoschizandrin Original Research Article
Pages 137-172
Gary A. Molander, Kelly M. George

Chapter 6 The synthesis of polycavernoside A. An example of conformationally guided macrolactonization Original Research Article
Pages 173-210
Paul R. Blakemore, James D. White

Chapter 7 First total synthesis of several natural products based on alkyne-Co2(CO)6 complexes Original Research Article
Pages 211-245
Chisato Mukai

Chapter 8 Total synthesis of myriaporones 1, 3, and 4 Original Research Article
Pages 246-268
Richard E. Taylor, Kristen N. Fleming, Brian R. Hearn

Chapter 9 Adventures in natural product synthesis: From deep sea sponge to pilot plant. The large scale total synthesis of the marine natural product (+)-discodermolide Original Research Article
Pages 269-320
Stuart J. Mickel

Chapter 10 Synthesis of aprepitant Original Research Article
Pages 321-351
Todd D. Nelson

Chapter 11 Total synthesis and mechanism of action studies on the antitumor alkaloid, (-)-agelastatin a Original Research Article
Pages 352-394
Karl J. Hale, Mathias M. Domostoj, Mohamed El-Tanani, F. Charles Campbell, Charlene K. Mason

Chapter 12 Design and synthesis of cooperative “pinwheel” fluorescent sensors Original Research Article
Pages 395-414
Joseph Raker, Kristen Secor, Ricardo Moran, Ellen Feuster, John Hanley, Timothy Glass

Chapter 13 Functionalization of pyridines and thiazoles via the halogen-dance reaction, application to the total synthesis of caerulomycin c and WS75624 B Original Research Article
Pages 415-436
Tarek Sammakia, Eric L. Stangeland, Mark C. Whitcomb

Chapter 14 Diastereoselective intramolecular 4+3 cycloaddition and an enantioselective total synthesis of (+)-dactylol Original Research Article
Pages 437-463
Paitoon Rashatasakhon, Michael Harmata

Index
Pages 465-476