More than 40 articles provide an extensive coverage of clinical and basic science advances over the last three years of research on subarachnoid hemorrhage-induced brain injuries. Early brain injury, the new frontier of subarachnoid research, which may be a key contributor to the high mortality and morbidity, promotes collaborative efforts from neurosurgery, neurology, neuro-ICU into other interrelated fields and basic neurosciences. For the first time, subarachnoid hermorrhage research is almost equally divided by early brain injury and cerebral vasospasm, mechanistic investigations and therapeutic approaches, demonstrating a translational feature of the future direction.
Author(s): Hua Feng, Ying Mao, John H. Zhang
Series: Acta Neurochirurgica Supplementum 2 110
Edition: 1st Edition.
Publisher: Springer
Year: 2010
Language: English
Pages: 267
Early Brain Injury or Cerebral Vasospasm: Volume 2: Clinical Management (Acta Neurochirurgica Supplementum, Suppl. 110/2)......Page 1
Front-matter......Page 2
Early Brain Injury or Cerebral Vasospasm......Page 4
Copyright......Page 5
Preface......Page 6
Acknowledgement......Page 8
Contents......Page 10
Part III: Therapeutical Studies......Page 15
APOE and Outcome After SAH......Page 17
References......Page 18
Introduction......Page 21
Results......Page 22
References......Page 23
Introduction......Page 25
Results......Page 26
Discussion......Page 27
References......Page 28
Introduction......Page 29
Statistical Analysis......Page 30
Expression of Rho-kinase (Fig. 3)......Page 31
Discussion......Page 32
References......Page 33
Animal Groups......Page 35
Neurological Parameters......Page 36
Mortality and Neurological Parameters......Page 37
Angiographic Measurements......Page 38
Discussion......Page 39
References......Page 40
Experimental Model of SAH and Study Protocol......Page 41
Intracerebroventricular Infusion......Page 42
Conclusion......Page 43
References......Page 44
Introduction......Page 45
Results......Page 46
Discussion......Page 47
References......Page 48
Introduction......Page 51
Temporal Profile of Changes in CSF Mg2+ and Ca2+ Concentrations......Page 52
Conclusion......Page 53
References......Page 54
Introduction......Page 55
Experimental Protocol......Page 56
Discussion......Page 57
Conclusion......Page 59
References......Page 60
Animal Preparations......Page 61
Statistical Analysis......Page 62
Discussion......Page 63
References......Page 64
Introduction......Page 67
Angiography Procedure......Page 68
Pathological Measurements......Page 69
Angiographic Measurements......Page 70
Discussion......Page 71
References......Page 72
Introduction......Page 73
Expressions of VEGF, NGF and HPS70 Detected by Immunohistochemistry......Page 74
NGF and HSP70 Expressions in Brain Tissue Detected by Immunohistochemistry......Page 75
Discussion......Page 76
References......Page 78
Introduction......Page 81
Embedding, Morphometry, and Statistical Analysis......Page 82
Discussion......Page 83
References......Page 85
Introduction......Page 87
Brain Water Content......Page 88
Histological Examination......Page 89
References......Page 91
Introduction......Page 93
Results......Page 94
References......Page 96
Introduction......Page 99
Materials and Methods......Page 100
Discussion......Page 101
References......Page 102
Materials and Methods......Page 107
Discussion......Page 108
References......Page 109
Clinical Material and Methods......Page 111
Results......Page 112
Selected Cases......Page 113
Discussion......Page 114
References......Page 116
Surgical Procedure and Postoperative Management......Page 117
Materials and Methods......Page 118
Discussion......Page 119
Conclusion......Page 120
References......Page 121
Patient Population......Page 123
Discussion......Page 124
References......Page 127
Introduction......Page 129
Clinical and Radiographic Assessment......Page 130
Results......Page 131
Discussion......Page 133
References......Page 134
Preoperative Treatment......Page 135
Discussion......Page 136
References......Page 137
Pathophysiology......Page 139
Clinical Indications and Efficacy......Page 140
Complication Avoidance and Management......Page 142
References......Page 143
Patient Population......Page 145
Results......Page 147
Discussion......Page 148
References......Page 150
Preoperative Treatment......Page 153
Discussion......Page 154
References......Page 155
Introduction......Page 157
Discussion......Page 158
References......Page 160
Material and Methods......Page 163
Discussion......Page 164
Conclusions......Page 166
References......Page 167
Introduction......Page 169
Conclusion......Page 170
References......Page 172
Nursing and Physiotherapy......Page 173
Critical Care......Page 174
Discussion......Page 175
References......Page 176
Development of NP......Page 177
Results......Page 178
References......Page 179
Materials and Methods......Page 181
Results......Page 182
References......Page 184
Materials and Methods......Page 187
Discussion......Page 188
References......Page 190
Results......Page 191
References......Page 193
Introduction......Page 195
Results......Page 196
Discussion......Page 197
References......Page 198
Imaging Examination......Page 201
Conclusion......Page 202
References......Page 203
Introduction......Page 205
Experimental Studies in Animals......Page 206
Randomized Controlled Trials and Meta-Analyses......Page 208
Observational Studies......Page 210
Conclusions......Page 211
References......Page 212
Materials and Methods......Page 215
Results......Page 216
Discussion......Page 218
References......Page 219
Material and Methods......Page 221
Results......Page 222
References......Page 223
Part IV: Imaging Studies......Page 227
Methods......Page 229
Results......Page 230
Discussion......Page 231
References......Page 232
Introduction......Page 233
Results......Page 234
Conclusion......Page 236
References......Page 237
Patients......Page 239
Result......Page 240
Discussion......Page 241
References......Page 243
Transcranial Doppler (TCD)......Page 245
Perfusion Computed Tomography (PCT) and Computed Tomography Angiography (CTA)......Page 246
Diffusion-Weighted Magnetic Resonance Imaging (DWI) and Perfusion-weighted Magnetic Resonance Imaging (PWI)......Page 247
References......Page 248
Introduction......Page 251
Image Analysis......Page 252
Discussion......Page 253
References......Page 256
Author Index......Page 259
Subject Index......Page 263
