Critical in the elimination of drugs and other xenobiotics from the body, cytochrome P450 has strong bearing on scientific assessments of genetic polymorphism in metabolism, possible drug–drug interactions, and bioavailability of candidate drugs. Drug Metabolizing Enzymes systematizes the latest findings on P450 and similar enzymes—as well as parallel issues shaping the pharmaceutical industry—to promote the next generation of safer, more effective drugs.
Author(s): Jae S. Lee, R. Scott Obach, Michael B. Fisher
Edition: 1
Publisher: Marcel Dekker
Year: 2003
Language: English
Commentary: 171897
Pages: 609
Front Cover......Page 1
Contents......Page 8
Editor's Preface......Page 18
Foreword......Page 20
1. Dioxygen Activation by Cytochromes P450: A Role for Multiple Oxidants in the Oxidation of Substrates......Page 22
2. Application of LC/MS, LC/NMR, NMR and Stable Isotopes in Identifying and Characterizing Metabolites......Page 54
3. Bioactivation......Page 108
4. Chemically Reactive Metabolites in Drug Discovery and Development......Page 168
5. Cytochrome P450 and its Place in Drug Discovery and Development......Page 176
6. Cytochrome P450 in Laboratory Animal Species......Page 200
7. Typical and Atypical Enzyme Kinetics......Page 232
8. Cytochrome P450 Reaction Phenotyping......Page 276
9. Drug-Drug Interactions and the Cytochromes P450......Page 332
10. CYP Gene Induction by Xenobiotics and Drugs......Page 358
11. Cytochrome P450 Pharmacogenetics......Page 396
12. Role of Intestinal Cytochromes P450 in Drug Disposition......Page 442
13. Prediction of Hepatic Clearance in Humans from Experimental Animals and In Vitro Data......Page 474
14. Non-P450 Mediated Oxidative Metabolism of Xenobiotics......Page 504
15. The Role of Sulfotransferases (SULTs) and UDP-GlucuronosyItransferases (UGTs) in Human Drug Clearance and Bioactivation......Page 562
Index......Page 598
