This is an authoritative, comprehensive book on the fate of drug molecules in the body, including implications for pharmacological and clinical effects. The text provides a unique, balanced approach, examining the specific physical and biological factors affecting the absorption, distribution, metabolism and excretion of drugs, together with mathematical assessment of the concentrations in plasma and body fluids. Understanding the equations requires little more than a basic knowledge of algebra, laws of indices and logarithms, and very simple calculus. A companion web site contains additional illustrations, further equations and numerous worked examples.Whilst this book has its roots in the highly acclaimed book of the same name, written by Stephen Curry nearly thirty years ago, it is essentially a new book having been restructured and largely rewritten. This readable and informative book is an invaluable resource for professionals and students needing to develop a rational approach to the investigation and application of drugs.
Author(s): Stephen H. Curry, Robin Whelpton
Edition: 1
Publisher: Wiley
Year: 2011
Language: English
Pages: 370
Drug Disposition and Pharmacokinetics: From Principles to Applications......Page 1
Editors......Page 2
Copyright......Page 3
Contents......Page 4
Preface......Page 15
About the Authors......Page 18
1.Chemical Introduction: Sources,Classification and Chemical Properties of Drugs......Page 19
2.Drug Administration and Distribution......Page 41
3.Drug Elimination......Page 70
4.Elementary Pharmacokinetics......Page 94
5.More Complex and Model Independent Pharmacokinetic Models......Page 116
6.Kinetics of Metabolism and Excretion......Page 137
7.Further Consideration of Clearance,and Physiological Modelling......Page 153
8.Drug Formulation: Bioavailability,Bioequivalence and Controlled-Release Preparations......Page 172
9.Factors Affecting Plasma Concentrations......Page 184
10.Pharmacogenetics and Pharmacogenomics......Page 201
11.Developmental Pharmacology and Age-related Phenomena......Page 214
12.Effects of Disease on Drug Disposition......Page 227
13.Quantitative Pharmacological Relationships......Page 248
14.Pharmacokinetic/Pharmacodynamic Modelling: Simultaneous Measurement of Concentrations and Effect......Page 259
15.Extrapolation from Animals to Human Beings and Translational Science......Page 278
16.Peptides and Other Biological Molecules......Page 288
17.Drug Interactions......Page 301
18.Drug Metabolism and Pharmacokinetics in Toxicology......Page 320
19.Drug Monitoring in Therapeutics......Page 335
Appendix.Mathematical Concepts and the Trapezoidal Method......Page 351
Acknowledgements......Page 357
Index......Page 358
