Drug Design: A Conceptual Overview

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The newer research areas in pharmaceutical sciences, particularly molecular modeling and simulations, prompted a more efficient drug discovery process. Informatics integrated with pharmaceutical sciences (cheminformatics and bioinformatics) became an essential component of drug research. Drug informatics such as genomics and proteomics assists in the Rational Drug Design (RDD). This emerging discipline is known as “Computer-Aided Drug Design" (CADD), which has profound application in RDD. The advanced and adequate practice in drug design informatics is essential for pharmacy graduates. Hence, a companion for acquiring knowledge on these concepts is vital. The students of B. Pharmacy, M. Pharmacy (Pharmaceutical Chemistry, Pharmacology, and Pharmaceutics), biotechnology, biomedical engineering and other interdisciplinary fields may find this book as a reference guide.
The salient features of this book are:
• Systematic and simple approach
• Emphasis on traditional and modern drug design strategies
• Comprehensive coverage for the current advances in the drug design
• Experimental section to ensure hands-on-experience

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Author(s): T. Durai Ananda Kumar
Publisher: CRC Press/PharmaMed Press
Year: 2022

Language: English
Pages: 485
City: Hyderabad

Cover
Half Title
Title Page
Copyright Page
Dedication
Foreword
Preface
Table of Contents
1. Drug Discovery Informatics
2. Receptors
3. Molecular Biology
4. Drug Discovery and Development
5. Quantitative -Structure Activity Relationship (QSAR)
6. Molecular Modeling
7. Virtual Screening
8. Molecular Docking
9. Sequence Analysis
10. Pairwise Sequence Alignment (PSA)
11. Molecular Evolution, Multiple Sequence Alignment (MSA) and Phylogenetic Analysis
12. Gene Prediction, Hidden Markov Model and Motif Identification
13. Structure Prediction
Appendix
Application of the in Silico Techniques in the Drug Discovery
Abbreviations
Glossary
Symbols
Index