Author(s): van de Waterbeemd H., Lennernas H., Artursson P.
Series: Methods and Principles in Medicinal Chemistry 18
Edition: 2., completely revised ed
Publisher: Weinheim WILEY-VCH-Verl. c
Year: 2003
Language: English
Pages: 597
Front Matter......Page 1
Contents......Page 5
Preface......Page 17
Foreword......Page 19
List of Authors......Page 20
I Studies of Membrane Permeability and Oral Absorption......Page 24
1 Physico-chemical Approaches to Drug Absorption......Page 25
2 High-throughput Measurement of log D and pK a......Page 43
3 High-throughput Measurement of Permeability Profiles......Page 68
4 Caco-2 and Emerging Alternatives for Prediction of Intestinal Drug Transport: A General Overview......Page 94
5 Cell Cultures in Drug Discovery : An Industrial Perspective......Page 112
6 Use of Animals for the Determination of Absorption and Bioavailability......Page 154
7 In vivo Permeability Studies in the Gastrointestinal Tract of Humans......Page 177
II Drug Dissolution and Solubility......Page 211
8 Gastrointestinal Dissolution and Absorption of Drugs......Page 212
9 Aqueous Solubility in Discovery, Chemistry, and Assay Changes......Page 236
10 Factors Influencing the Water Solubilities of Crystalline Drugs......Page 253
III Role of Transporters and Metabolism in Oral Absorption......Page 264
11 Transporters in the GI Tract......Page 265
12 Hepatic Transport......Page 308
13 The Importance of Gut Wall Metabolism in Determining Drug Bioavailability......Page 331
14 Modified Cell Lines......Page 349
IV Computational Approaches to Drug Absorption and Bioavailability......Page 359
15 Intestinal Absorption: the Role of Polar Surface Area......Page 360
16 Calculated Molecular Properties and Multivariate Statistical Analysis in Absorption Prediction......Page 377
17 VOLSURF: A Tool for Drug ADME-properties Prediction......Page 425
18 Simulation of Absorption, Metabolism, and Bioavailability......Page 439
19 Prediction of Bioavailability......Page 463
20 Towards P-Glycoprotein Structure–Activity Relationships......Page 480
V Drug Development Issues......Page 512
21 Application of the Biopharmaceutic Classification System Now and in the Future......Page 513
22 Prodrugs......Page 550
23 Modern Delivery Strategies: Physiological Considerations for Orally Administered Medications......Page 565
Index......Page 587
