This updated and revised 2nd edition of "Drug Benefits and Risks" is an inclusive reference exploring the scientific basis and practice of drug therapy. The key concept is to look at the balance between the benefits and risks of drugs, but in this context also highlighting the social impact which drugs have in modern societies. Taking an evidence-based approach to the problem, the practice of clinical pharmacology and pharmacotherapy in the developing as well as the developed world is examined. For this purpose, the book covers general clinical pharmacology, pharmacology of various drug groups and the treatments specific to various diseases; the book gives guidance on how doctors should act so that drugs can be used effectively and safely; and it encourages the rational use of drugs in society.This publication brings together a large amount of excellent content that will be invaluable for anyone working within, or associated with, the field of clinical pharmacology and pharmacotherapy - undergraduates, postgraduates, regulatory authorities and the pharmaceutical industry.
Author(s): Chris J. Van Boxtel, Budiono Santoso, I. Ralph Edwards
Edition: 2 Revised
Publisher: IOS Press
Year: 2008
Language: English
Pages: 846
Title page......Page 1
Contents......Page 5
Contributors......Page 9
Foreword to the Second Edition......Page 15
Foreword to the First Edition......Page 17
Preface to the Second Edition......Page 19
Preface to the First Edition......Page 21
Part A Medicinals in Society......Page 25
A Drug Benefits......Page 27
B Drug Risks......Page 33
2 Therapeutics as a Science......Page 39
3 Pharmacoepidemiology and Drug Evaluation......Page 51
4 Economic Evaluation of Pharmaceuticals and Clinical Practice......Page 61
5 Clinical Pharmacology and Drug Policy......Page 81
6 Drug Regulation: History, Present and Future......Page 89
7 Medicines in Developing Countries......Page 103
8 Drug Information......Page 123
9 Drug Development......Page 131
Part B General Clinical Pharmacology......Page 145
10 Clinical Pharmacokinetics......Page 147
11 Clinical Pharmacodynamics......Page 189
12 Drug Therapy in Pediatric Patients......Page 205
13 Drug Therapy in Older Persons......Page 227
14 Adverse Drug Reactions......Page 249
15 Drug–Drug Interactions......Page 271
16 Drug Misuse – Harmful Use, Abuse and Dependence......Page 287
17 Clinical Pharmacology of Poisoning......Page 299
Section II Pharmacotherapeutic Products......Page 311
18 Neurohumoral Transmission......Page 313
19 Autacoids......Page 335
20 Drugs Affecting Cardiovascular and Renal Functions......Page 347
21 Drugs Acting on the Central Nervous System......Page 371
22 Hemopoietic Drugs and Drugs that Affect Coagulation......Page 391
23 Drugs Affecting Gastrointestinal Function......Page 401
24 Hormones and Hormone Antagonists......Page 411
25 Antimicrobial Agents......Page 431
26 Analgesics, Antirheumatics and Drugs for the Treatment of Gout......Page 459
27 Antineoplastic Agents......Page 471
28 Drugs Used for Immunomodulation......Page 489
29 Vitamins......Page 495
30 Dermatologicals and Miscellaneous Agents......Page 503
Section III Treatment of Health Problems......Page 513
31 Symptomatic Treatment......Page 515
32 Emergency Medicine......Page 529
A Treatment and Prophylaxis of Infectious Diseases......Page 545
B Treatment of HIV/AIDS and of Tuberculosis......Page 573
A Pharmacotherapy of Hypertension......Page 595
B
Treatment of Ischemic Heart Disease......Page 611
C
Treatment of Heart Failure......Page 617
D Pharmacological Treatment of Cardiac Arrhythmias......Page 623
E Pharmacological Treatment of Renal Diseases......Page 633
35 Gastrointestinal and Hepatobiliary Disorders......Page 643
36 Pharmacotherapy of Chronic Obstructive Pulmonary Disease and Asthma......Page 661
37 Disorders of Connective Tissue, Bone and Joints......Page 683
38 Treatment of Psychiatric Disorders......Page 699
39 Neurological Diseases......Page 709
40 Drug Use for Malignancies......Page 731
41 Haematological Disorders......Page 753
42 Endocrine Diseases......Page 775
Index......Page 805
