Dopamine Receptors

Title Page
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Half Title Page
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Copyright
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ACS Symposium Series......Page 5
FOREWORD......Page 6
EDITORS' PREFACE......Page 7
PREFACE......Page 9
Literature Cited......Page 12
PdftkEmptyString......Page 0
1 D-1 Dopamine Receptor-Mediated Activation of Adenylate Cyclase, cAMP Accumulation, and PTH Release in Dispersed Bovine Parathyroid Cells......Page 13
Dopamine Enhances cAMP Accumulation in Dispersed Bovine Parathyroid Cells......Page 14
Dopamine Stimulates Adenylate Cyclase Activity of Dispersed Bovine Parathyroid Cells......Page 17
Does cAMP Trigger the Release of IR-PTH?......Page 22
Receptors Inhibiting Dopamine-stimulated cAMP Accumulation and PTH Secretion......Page 24
Possible Role of Dopamine in Regulating PTH Secretion In Vivo......Page 26
Relationship of Dopamine Receptors on Bovine Parathyroid Cells to Other Dopamine Receptors: Dopamine Receptors Stimulating Adenylate Cyclase Activity......Page 27
Dopamine Receptors Inhibiting Adenylate Cyclase Activity......Page 29
Literature Cited......Page 31
Commentary: Dopamine-Sensitive Adenylate Cyclase as a Receptor Site......Page 34
Is Dopamine-Sensitive Adenylate Cyclase a Dopamine Receptor ?......Page 35
Is Parathormone Secretion Mediated through a Dopamine D1 Site ?......Page 37
Literature Cited......Page 40
Dr. Brown's Replies to Dr. Laduron's Comments......Page 41
Literature Cited......Page 43
2 The D-2 Dopamine Receptor in the Intermediate Lobe of the Rat Pituitary Gland Physiology, Pharmacology, and Biochemistry......Page 44
Cyclic AMP and the Intermediate Lobe β-adrenoceptor......Page 46
Cyclic AMP and the Intermediate Lobe Dopamine Receptor......Page 52
Concluding Remarks......Page 59
Literature Cited......Page 61
Commentary: The DA_ Dopamine Receptor in the Anterior and Intermediate Lobes of the Pituitary Gland......Page 64
The dopamine receptor in the anterior pituitary gland is negatively coupled to adenylate cyclase......Page 65
Modulation of the anterior pituitary dopamine receptor by gonadal steroids......Page 67
The dopamine receptor in the intermediate lobe of the pituitary gland is negatively coupled to adenylate cyclase......Page 68
Coupling of dopamine receptors with adenylate cyclase: DA+, DA_ and DA0 receptors......Page 71
Corticotropin-releasing factor stimulates adenylate cyclase in the intermediate lobe of the pituitary gland......Page 74
Literature Cited......Page 80
3 The Dopamine Receptor of the Anterior Pituitary Gland Ligand Binding and Solubilization Studies......Page 84
Quantitative Relationship of Agonist and Antagonist Ligand Binding to Porcine Anterior Pituitary Gland Membranes......Page 86
Guanine Nucleotides Modulation of Receptor Affinity for Agonists......Page 87
N-ethylmaleimide and Heat Treatments of Membranes Mimic the Effect of Guanine Nucleotides on Ligand Binding......Page 91
Solubilization of the Dopamine Receptor......Page 95
Conclusions......Page 97
Literature Cited......Page 101
Commentary: The Dopamine Receptor of the Anterior Pituitary Gland......Page 104
Literature Cited......Page 109
4 Differentiation of Dopamine Receptors in the Periphery......Page 111
DA1 receptors......Page 112
DA2 agonists......Page 115
DA2 antagonists......Page 117
Comparison of data obtained in vivo and in vitro......Page 119
Determinations of the DA receptor subtypes responsible for physiological and pharmacological actions......Page 121
Literature Cited......Page 122
Commentary: Utility and Problems in the Classification of Dopamine Receptors......Page 124
Four Major Reasons for Problems in the Classification and Identification of Dopamine Receptors in the Periphery......Page 125
Conclusion......Page 126
5 Dopamine Receptors in the Neostriatum: Biochemical and Physiological Studies......Page 127
A Postsynaptic Dopamine Receptor Regulating the Release or Turnover of Acetylcholine......Page 128
A Postsynaptic Dopamine Receptor Regulating the Release or Turnover of GABA?......Page 135
A Postsynaptic Dopamine Receptor Regulating the Release or Turnover of Glutamate?......Page 136
A Postsynaptic Dopamine Receptor Regulating the Release or Turnover of Peptide Neurotransmitters?......Page 137
A Postsynaptic Dopamine Receptor Regulating Cyclic AMP Formation......Page 138
Autoreceptors Regulating the Turnover of Dopamine......Page 142
Presynaptic Autoreceptor Regulating the Release of Dopamine......Page 144
A Presynaptic Autoreceptor Regulating cyclic AMP Formation?......Page 145
Concluding Remarks......Page 148
Literature Cited......Page 150
6 Potential Therapeutic Uses of Dopamine Receptor Agonists and Antagonists
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Dopamine Agonists......Page 157
Dopamine Antagonists......Page 159
Literature Cited......Page 161
Commentary: Potential Therapeutic Uses of Dopamine Receptor Agonists and Antagonists......Page 163
Literature Cited......Page 164
7 Dopaminergic Benzazepines with Divergent Cardiovascular Profiles......Page 165
Benzazepine Chemistry......Page 166
Benzazepine Pharmacology......Page 168
Discussion......Page 174
Literature Cited......Page 175
Commentary: Dilemmas in the Synthesis of Clinically Useful Dopamine Agonists......Page 178
Literature Cited......Page 181
8 Dopamine Agonists and Antagonists in Duodenal Ulcer Disease......Page 182
Structure-activity Relationship of Duodenal Ulcerogens......Page 183
Pharmacologic Modulation with Dopamine-related Drugs......Page 188
Biochemical Studies with Catecholamines......Page 194
Correlations and Implications......Page 195
Literature Cited......Page 200
Commentary: Dopamine Agonists and Antagonists in Duodenal Ulcer Disease......Page 204
9 The Development of Novel Dopamine Agonists......Page 207
Structural Dissection......Page 208
Rigidification......Page 212
Stereochemistry and Absolute Configuration......Page 215
Hydrophobic features of the receptor......Page 216
Importance of nitrogen electron pair orientation......Page 219
Literature Cited......Page 223
Commentary: The Development of Novel Dopamine Agonists......Page 225
Literature Cited......Page 227
10 Stereoisomeric Probes of the Dopamine Receptor......Page 228
Pharmacology of (R) and (S)-I-III......Page 230
Structure-Activity Relationship Considerations......Page 233
Footnotes to Table I.......Page 235
Discussion......Page 238
Literature Cited......Page 246
Commentary: Stereoisomeric Probes of the Dopamine Receptor......Page 252
Literature Cited......Page 255
Structural Requirements......Page 256
A Hypothetical Receptor Model......Page 257
Development of a Pyrroloisoquinoline Antipsychotic (Ro 22-1319)......Page 262
Pharmacology and Biochemistry of Ro 22-1319......Page 265
The Auxiliary Binding Site and Selectivity for D-2 and D-1 Dopamine Receptor's......Page 270
Literature Cited......Page 278
12 Renal Vascular Dopamine Receptor Topography Structure-Activity Relationships That Suggest the Presence of a Ceiling......Page 280
Literature Cited......Page 285
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