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DNA and RNA Nanobiotechnologies in Medicine: Diagnosis and Treatment of Diseases

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This book will provide latest insights in the functional potentials of ribonucleic acids in medine and the use of Spiegelmer and Spiegelzyme systems. It will also deal with a new type of delivery systems for cellular targeting.

Author(s): Dhiraj Bhatia, Yamuna Krishnan (auth.), Volker A. Erdmann, Jan Barciszewski (eds.)
Series: RNA Technologies
Edition: 1
Publisher: Springer-Verlag Berlin Heidelberg
Year: 2013

Language: English
Pages: 460
Tags: Molecular Medicine; Nucleic Acid Chemistry; Human Genetics

Front Matter....Pages i-viii
Designer Nucleic Acid-Based Devices in Nanomedicine....Pages 1-10
Characterizing Functionalized DNA for Use in Nanomedicine....Pages 11-41
Nanoparticles to Deliver Antisense Oligonucleotides Aimed at Exon Skipping Therapies....Pages 43-66
Nanotechnological Approaches for Genetic Immunization....Pages 67-120
DNA-Functionalized Gold Nanoparticles for Metabolite and Nucleic Acid Detection....Pages 121-139
Gene Expression Analysis Using Conventional and Imaging Methods....Pages 141-162
Nucleic Acid-Based Encapsulations for Cancer Diagnostics and Drug Delivery....Pages 163-187
The Challenges and Current Advances in Delivering RNAi as Therapeutics....Pages 189-224
Nucleic Acid Nanotechnology: Modified Backbones and Topological Polymer Templates....Pages 225-240
The “Non-viral” Approach for siRNA Delivery in Cancer Treatment: A Special Focus on Micelles and Liposomes....Pages 241-261
RNA Nanoparticles for Gene Expression Regulation....Pages 263-290
Fluorescent Nucleic Acid Probes in Living Cells....Pages 291-328
Biomedical Applications for Nucleic Acid Nanodevices....Pages 329-348
Nanoscale-Based Delivery of RNAi for Cancer Therapy....Pages 349-372
The Sonochemical Fabrication of RNA and DNA Nanospheres....Pages 373-394
RNA Nanotechnology Approach for Targeted Delivery of RNA Therapeutics Using Cell-Internalizing Aptamers....Pages 395-423
Aptamers: Analytical Tools for Viral Components....Pages 425-442
Back Matter....Pages 443-460