This book contains selected contributions of papers, many presented at the Second International Workshop on Neural Modeling of Brain Disorders, as well as a few additional papers on related topics, including a wide range of presentations describing computational models of neurological, neuropsychological and psychiatric disorders. It is a unique, comprehensive review of the state-of-the-art of modeling cognitive and brain disorders, appealing to a multidisciplinary audience of clinicians, psychologists, neuroscientists, cognitive scientists, computer scientists, and other neural network researchers. The rest of the book is organized along four main themes, involving memory, neuropsychological, neurological and psychiatric disorders. In general, the cognitive disorders and these psychiatric diseases traditionally regarded as "functional" were modeled along functional lines, while those disorders traditionally viewed as "organic" neurological diseases generally drew more from knowledge of the underlying neurobiology and pathophysiology.
Author(s): James A. Reggia, Eytan Ruppin and Dennis Glanzman (Eds.)
Series: Progress in Brain Research 121
Edition: 1
Publisher: Elsevier, Academic Press
Year: 1999
Language: English
Pages: iii-xvii, 3-437
Content:
Edited by
Page iii
Copyright Page
Page iv
List of contributors
Pages v-vii
Introduction: Understanding brain and cognitive disorders: the computational perspective
Pages ix-xv
Eytan Ruppin, James A. Reggia, Dennis Glanzman
Acknowledgements
Page xvii
Chapter 1 Neuromodulation and the hippocampus: memory function and dysfunction in a network simulation Original Research Article
Pages 3-18
Michael E. Hasselmo
Chapter 2 Cholinergic neuromodulation and Alzheimer's disease: from single cells to network simulations Original Research Article
Pages 19-45
Elliot D. Menschik, Leif H. Finkel
Chapter 3 Episodic memory in semantic dementia: a computational approach based on the TraceLink model Original Research Article
Pages 47-65
Kim S. Graham, Jaap M.J. Murre, John R. Hodges
Chapter 4 Multimodular networks and semantic memory impairments Original Research Article
Pages 67-72
David Horn, Nir Levy, Eytan Ruppin
Chapter 5 Understanding failures of learning: Hebbian learning, competition for representational space, and some preliminary experimental data Original Research Article
Pages 75-80
James L. McClelland, Adam G. Thomas, Bruce D. McCandliss, Julie A. Fiez
Chapter 6 Frames of reference in hemineglect: a computational approach Original Research Article
Pages 81-97
A. Pouget, S. Deneve, T.J. Sejnowski
Chapter 7 Explaining object-based deficits in unilateral neglect without object-based frames of reference Original Research Article
Pages 99-119
Michael C. Mozer
Chapter 8 Inter-hemispheric competition of sub-cortical structures is a crucial mechanism in paradoxical lesion effects and spatial neglect Original Research Article
Pages 121-141
Claus-C. Hilgetag, Rolf Kötter, Malcolm P. Young
Chapter 9 A new model of letter string encoding: simulating right neglect dyslexia Original Research Article
Pages 143-163
Carol Whitney, Rita Sloan Berndt
Chapter 10 Prosopagnosia in modular neural network models Original Research Article
Pages 165-184
Matthew N. Dailey, Garrison W. Cottrell
Chapter 11 Functional brain imaging and modeling of brain disorders Original Research Article
Pages 185-200
M.-A. Tagamets, Barry Horwitz
Chapter 12 Unmasking unmasked: neural dynamics following stroke Original Research Article
Pages 203-218
William W. Lytton, Samuel T. Williams, Samuel J. Sober
Chapter 13 Effects of callosal lesions in a computational model of single-word reading Original Research Article
Pages 219-242
Jasmeet Chhabra, Mark Glezer, Yuri Shkuro, Shaun D. Gittens, James A. Reggia
Chapter 14 Penumbral tissue damage following acute stroke: a computational investigation Original Research Article
Pages 243-260
Eytan Ruppin, Kenneth Revett, Elad Ofer, Sharon Goodall, James A. Reggia
Chapter 15 The gating functions of the basal ganglia in movement control Original Research Article
Pages 261-276
José L. Contreras-Vidal
Chapter 16 Motor fluctuations in Parkinson's disease: a postsynaptic mechanism derived from a striatal model Original Research Article
Pages 277-288
Rolf Kötter
Chapter 17 Thalamic and thalamocortical mechanisms underlying 3 Hz spike-and-wave discharges Original Research Article
Pages 289-307
Alain Destexhe, David A. McCormick, Terrence J. Sejnowski
Chapter 18 Using a speech perception neural network simulation to explore normal neurodevelopment and hallucinated ‘voices’ in schizophrenia Original Research Article
Pages 311-325
Ralph E. Hoffman, Thomas H. McGlashan
Chapter 19 Dopamine, cognitive control, and schizophrenia: the gating model Original Research Article
Pages 327-349
Todd S. Braver, Jonathan D. Cohen
Chapter 20 Modeling prefrontal cortex delay cells: the role of dopamine in schizophrenia Original Research Article
Pages 351-373
Alastair Reid, David Willshaw
Chapter 21 Neural models of normal and abnormal behavior: what do schizophrenia, parkinsonism, attention deficit disorder, and depression have in common? Original Research Article
Pages 375-406
Stephen Grossberg
Chapter 22 A neural network model of attention biases in depression Original Research Article
Pages 407-432
Greg J. Siegle
Subject Index
Pages 433-437
